Florian Bochen
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View article: <scp>TRPM4</scp> contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system
<span>TRPM4</span> contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system Open
Transient receptor potential melastatin‐4 ( TRPM4 ) ion channel expression is upregulated in prostate cancer (PCa), contributing to increased cell proliferation, migration, adhesion, epithelial‐to‐mesenchymal transition, cell cycle shift, …
View article: A Simple and Fast Method for the Formation and Downstream Processing of Cancer-Cell-Derived 3D Spheroids: An Example Using Nicotine-Treated A549 Lung Cancer 3D Spheres
A Simple and Fast Method for the Formation and Downstream Processing of Cancer-Cell-Derived 3D Spheroids: An Example Using Nicotine-Treated A549 Lung Cancer 3D Spheres Open
Although 2D in vitro cancer cell cultures have been used for decades as a first line-of-research tool to investigate antitumoral drugs and treatments, their use presents many drawbacks, including the poor resemblance of such cultures to th…
View article: Contribution of the α5 nAChR Subunit and α5SNP to Nicotine-Induced Proliferation and Migration of Human Cancer Cells
Contribution of the α5 nAChR Subunit and α5SNP to Nicotine-Induced Proliferation and Migration of Human Cancer Cells Open
Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many studies have associated the α5 nicotinic receptor subunit (α5), and…
View article: Targeting Ion Channel TRPM4
Targeting Ion Channel TRPM4 Open
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified s…
View article: Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer
Antagonizing Sec62 function in intracellular Ca2+ homeostasis represents a novel therapeutic strategy for head and neck cancer Open
Various cancer types including head and neck squamous cell carcinomas (HNSCC) show a frequent amplification of chromosomal region 3q26 that encodes, among others, for the SEC62 gene. Located in the ER membrane, this translocation protein i…
View article: Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients
Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients Open
Introduction Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnos…
View article: Podoplanin expression in lymphoid metastases of head and neck cancer
Podoplanin expression in lymphoid metastases of head and neck cancer Open
Introduction Head and neck squamous cell carcinomas (HNSCC) have been associated with a poor prognosis for decades, with more than half of the patients already showing lymph node metastases at the time of diagnosis. The CUP syndrome (Cance…
View article: Investigations on the prognostic relevance of tumor-infiltrating immune cells in HNSCC patients on the basis of RNAseq data from the TCGA-HNSC cohort and immunohistochemical validation on 101 patients
Investigations on the prognostic relevance of tumor-infiltrating immune cells in HNSCC patients on the basis of RNAseq data from the TCGA-HNSC cohort and immunohistochemical validation on 101 patients Open
Introduction Due to the increasing value of immune checkpoint inhibition in the therapeutic spectrum for HNSCC patients this scientific work carves out the prognostic relevance of tumor infiltrating immune cells. In this connection, RNA se…
View article: Proliferation and migration inhibitory effect of calcitriol on head and neck cancer cells – a new therapeutic approach for the treatment of head and neck tumor patients?
Proliferation and migration inhibitory effect of calcitriol on head and neck cancer cells – a new therapeutic approach for the treatment of head and neck tumor patients? Open
Introduction Despite the development of new therapeutic approaches for head and neck squamous cell carcinomas (HNSCC), this disease is still associated with high mortality and poor prognosis. Preclinical and epidemiological studies in rece…
View article: T-cell exhaustion and stroma senescence – the impact of tumor microenvironment on tumor cell biology and prognosis of head and neck carcinomas
T-cell exhaustion and stroma senescence – the impact of tumor microenvironment on tumor cell biology and prognosis of head and neck carcinomas Open
Introduction Immunooncology has gained importance in the treatment of head and neck cancer patients (HNSCC) over the past years and has found its way into the clinical practice of head and neck oncology. Nevertheless, many patients show no…
View article: HPV Status as Prognostic Biomarker in Head and Neck Cancer—Which Method Fits the Best for Outcome Prediction?
HPV Status as Prognostic Biomarker in Head and Neck Cancer—Which Method Fits the Best for Outcome Prediction? Open
The incidence of human papillomavirus (HPV)-related head and neck cancer (HNSCC) is rising globally, presenting challenges for optimized clinical management. To date, it remains unclear which biomarker best reflects HPV-driven carcinogenes…
View article: Impact of vitamin D on the lytic signature of tumor infiltrating leucocytes in patients with head and neck squamous cell carcinoma
Impact of vitamin D on the lytic signature of tumor infiltrating leucocytes in patients with head and neck squamous cell carcinoma Open
Introduction Several studies have shown that patients with head and neck squamous cell carcinoma (HNSCC) often suffer from a significant vitamin D deficiency, which is associated with a poor prognosis. Considering the evidence that an adeq…
View article: Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex
Complexity and Specificity of Sec61-Channelopathies: Human Diseases Affecting Gating of the Sec61 Complex Open
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the roughly one hundred components, which are involved in protein import …
View article: Expression of SEC62 Oncogene in Benign, Malignant and Borderline Melanocytic Tumors—Unmasking the Wolf in Sheep’s Clothing?
Expression of SEC62 Oncogene in Benign, Malignant and Borderline Melanocytic Tumors—Unmasking the Wolf in Sheep’s Clothing? Open
SEC62 oncogene located at chromosomal region 3q26 encodes for a transmembrane protein of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. SEC62 overexpression has been associated with worse pro…
View article: Augmented reality‐enhanced navigation in endoscopic sinus surgery: A prospective, randomized, controlled clinical trial
Augmented reality‐enhanced navigation in endoscopic sinus surgery: A prospective, randomized, controlled clinical trial Open
Objective Endoscopic sinus surgery represents the gold standard for surgical treatment of chronic sinus diseases. Thereby, navigation systems can be of distinct use. In our study, we tested the recently developed KARL STORZ NAV1 SinusTrack…
View article: Podoplanin expression in lymphogenic metastases of head and neck cancer
Podoplanin expression in lymphogenic metastases of head and neck cancer Open
Introduction Head and neck squamous cell carcinomas (HNSCC) have been associated with a poor prognosis for decades, with more than half of the patients already showing lymph node metastases at the time of diagnosis. CUP syndrome (Cancer of…
View article: HPV status as predictive biomarker in head and neck cancer – which method fits the best for outcome prediction?
HPV status as predictive biomarker in head and neck cancer – which method fits the best for outcome prediction? Open
Introduction Head and neck squamous cell carcinomas (HNSCCs) belong to the six most commen cancers worlwide and are associated with a poor prognosis. Over the past years, infection of the oral mucosa with high risk human papillomavirus (HP…
View article: Impact of vitamin D on the lytic signature of tumor infiltrating leucocytes in patients with head and neck squamous cell carcinoma
Impact of vitamin D on the lytic signature of tumor infiltrating leucocytes in patients with head and neck squamous cell carcinoma Open
Introduction Several studies have shown that patients with head and neck squamous cell carcinoma (HNSCC) often suffer from a significant vitamin D deficiency, which is associated with a poor prognosis. Considering the evidence that an adeq…
View article: Thapsigargin (TG) and Trifluoperazine (TFP) suppress tumor growth and metastasis of head and neck cancer in vitro und in vivo
Thapsigargin (TG) and Trifluoperazine (TFP) suppress tumor growth and metastasis of head and neck cancer in vitro und in vivo Open
Head and neck squamous cell carcinomas (HNSCCs) belong to the six most common cancers worldwide. In advanced tumor stages, therapeutic strategies are limited. As shown by our group, the majority of HNSCCs shows an overexpression of the SEC…
View article: Impact of vitamin D and HPV on the immunecheckpoint molecule expression in head and neck squamous cell carcinoma
Impact of vitamin D and HPV on the immunecheckpoint molecule expression in head and neck squamous cell carcinoma Open
Vitamin D deficiency is frequently observed among patients with head and neck squamous cell carcinoma (HNSCC), being associated with an impaired antitumor immune activity.
View article: Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features
Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features Open
Atypical fibroxanthoma (AFX) is a rare mesenchymal tumor with predominance in older male patients located mainly in chronically UV-exposed skin. Differentiation from clinically more aggressive pleomorphic dermal sarcoma (PDS) is still unde…
View article: Vitamin D deficiency in head and neck cancer patients – prevalence, prognostic value and impact on immune function
Vitamin D deficiency in head and neck cancer patients – prevalence, prognostic value and impact on immune function Open
Vitamin D deficiency is frequently observed in human cancer patients and a prognostic relevance could be shown for some entities. Additionally, it is known that vitamin D can stimulate the patients' antitumor immunity. However, valid epide…
View article: Virulence function of the <i>Ustilago maydis</i> sterol carrier protein 2
Virulence function of the <i>Ustilago maydis</i> sterol carrier protein 2 Open
Summary The peroxisomal sterol carrier protein 2 (Scp2) of the biotrophic maize pathogen Ustilago maydis was detected in apoplastic fluid, suggesting that it might function as a secreted effector protein. Here we analyze the role of the sc…
View article: Treatment of <i>SEC62</i> over-expressing tumors by Thapsigargin and Trifluoperazine
Treatment of <i>SEC62</i> over-expressing tumors by Thapsigargin and Trifluoperazine Open
Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to th…
View article: Effect of 3q oncogenes <i>SEC62</i> and <i>SOX2</i> on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas
Effect of 3q oncogenes <i>SEC62</i> and <i>SOX2</i> on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas Open
Chromosome 3q26 amplification represents a frequent alteration in head and neck squamous cell carcinomas (HNSCCs). Overexpression of 3q26 encoded genes SEC62 and SOX2 was detected in various cancers, including HNSCCs, indicating their pote…
View article: Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions
Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions Open
Our study suggests SEC62 as a target gene of 3q26 amplification and a stimulator of cellular migration in dysplastic cervical lesions. Hence, SEC62 could serve as a potential marker for 3q amplification, providing useful information about …