Florian Daressy
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View article: In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration
In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration Open
View article: NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes
NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes Open
View article: Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL‐1
Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL‐1 Open
Drimane sesquiterpenoid dialdehydes are natural compounds with antiproliferative properties. Nevertheless, their mode of action has not yet been discovered. Herein, we demonstrate that various drimanes are potent inhibitors of MCL‐1 and BC…
View article: Caractérisation et études précliniques d'un nouvel inhibiteur naturel de MCL-1
Caractérisation et études précliniques d'un nouvel inhibiteur naturel de MCL-1 Open
Proteins of the BCL-2 family play a major role in cellular homeostasis since they regulate apoptotic cell death through dynamic interactions between the anti- and pro-apoptotic members. Over-expression of anti-apoptotic members (BCL-2, BCL…
View article: Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2
Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2 Open