Florian Geiger
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View article: Is the anterior approach still superior to posterior correction in AIS regarding correction, fusion levels and kyphosis when modern posterior systems are used?
Is the anterior approach still superior to posterior correction in AIS regarding correction, fusion levels and kyphosis when modern posterior systems are used? Open
View article: Differences in mortality after conservatively treated and augmented osteoporotic vertebral fractures - A meta-analysis and systematic review
Differences in mortality after conservatively treated and augmented osteoporotic vertebral fractures - A meta-analysis and systematic review Open
View article: The indication of fusion to the pelvis in neuromuscular scoliosis is based on the underlying disease rather than on pelvic obliquity
The indication of fusion to the pelvis in neuromuscular scoliosis is based on the underlying disease rather than on pelvic obliquity Open
Introduction The decision to instrument to L5 or ilium, in NMS, is usually based on radiologic factors, including pelvic obliquity (PO) > 15°, apex of curvature < L3, and Cobb angle > 60°. Since scoliosis in these patients is caused by a n…
View article: Is the anterior approach still superior to posterior correction in AIS regarding fusion levels and kyphosis, when modern posterior systems are used for AIS correction?
Is the anterior approach still superior to posterior correction in AIS regarding fusion levels and kyphosis, when modern posterior systems are used for AIS correction? Open
View article: Derotation screws provide no advantage over polyaxial screws regarding coronal & sagittal correction in thoracic curves of AIS patients
Derotation screws provide no advantage over polyaxial screws regarding coronal & sagittal correction in thoracic curves of AIS patients Open
Purpose We compared two techniques for thoracic apical derotation; one using conventional reduction screws (Single-Innie–SI) and one requiring special derotation screws that can be converted to monoaxial screws to enhance dorotation (Dual-…
View article: A study on the approximation power of NURBS and the significance of exact geometry in isogeometric pre-buckling analyses of shells
A study on the approximation power of NURBS and the significance of exact geometry in isogeometric pre-buckling analyses of shells Open
We present a comprehensive study on the approximation power of NURBS and the significance of exact geometry in stability analyses of shells. Pre-buckling analyses are carried out to estimate the critical load levels and the initial bucklin…
View article: AI Prediction of Neuropathic Pain after Lumbar Disc Herniation—Machine Learning Reveals Influencing Factors
AI Prediction of Neuropathic Pain after Lumbar Disc Herniation—Machine Learning Reveals Influencing Factors Open
The treatment options for neuropathic pain caused by lumbar disc herniation have been debated controversially in the literature. Whether surgical or conservative therapy makes more sense in individual cases can hardly be answered. We have …
View article: An Evolution Gaining Momentum—The Growing Role of Artificial Intelligence in the Diagnosis and Treatment of Spinal Diseases
An Evolution Gaining Momentum—The Growing Role of Artificial Intelligence in the Diagnosis and Treatment of Spinal Diseases Open
In recent years, applications using artificial intelligence have been gaining importance in the diagnosis and treatment of spinal diseases. In our review, we describe the basic features of artificial intelligence which are currently applie…
View article: Treatment of Unspecific Back Pain in Children and Adolescents: Results of an Evidence-Based Interdisciplinary Guideline
Treatment of Unspecific Back Pain in Children and Adolescents: Results of an Evidence-Based Interdisciplinary Guideline Open
Using a structured approach and expert consensus, we developed an evidence-based guideline on the treatment and prevention of non-specific back pain in children and adolescents. A comprehensive and systematic literature search identified r…
View article: Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation
Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation Open
Invasion is strongly influenced by the mechanical properties of the extracellular matrix. Here, we use microfluidics to align fibers of a collagen matrix and study the influence of fiber orientation on invasion from a cancer cell spheroid.…
View article: Etiology, Risk Factors, and Diagnosis of Back Pain in Children and Adolescents: Evidence- and Consensus-Based Interdisciplinary Recommendations
Etiology, Risk Factors, and Diagnosis of Back Pain in Children and Adolescents: Evidence- and Consensus-Based Interdisciplinary Recommendations Open
Using a structured approach and expert consensus, we developed an evidence-based guideline on the diagnosis of back pain and the treatment of non-specific back pain in children and adolescents. The first part comprises etiology, risk facto…
View article: Combined Artificial Intelligence Approaches Analyzing 1000 Conservative Patients with Back Pain—A Methodological Pathway to Predicting Treatment Efficacy and Diagnostic Groups
Combined Artificial Intelligence Approaches Analyzing 1000 Conservative Patients with Back Pain—A Methodological Pathway to Predicting Treatment Efficacy and Diagnostic Groups Open
Patients with back pain are common and present a challenge in everyday medical practice due to the multitude of possible causes and the individual effects of treatments. Predicting causes and therapy efficien cy with the help of artificial…
View article: Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses Open
View article: Motion Design with Efficient Actuator Placement for Adaptive Structures that Perform Large Deformations
Motion Design with Efficient Actuator Placement for Adaptive Structures that Perform Large Deformations Open
Adaptive structures have great potential to meet the growing demand for energy efficiency in buildings and engineering structures. While some structures adapt to varying loads by a small change in geometry, others need to perform an extens…
View article: Constrained motion design with distinct actuators and motion stabilization
Constrained motion design with distinct actuators and motion stabilization Open
The design of adaptive structures is one method to improve sustainability of buildings. Adaptive structures are able to adapt to different loading and environmental conditions or to changing requirements by either small or large shape chan…
View article: Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates
Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates Open
RNA viruses induce formation of subcellular organelles that provide microenvironments conducive to their replication. Here we show that replication factories of rotaviruses represent protein-RNA condensates that are formed via liquid-liqui…
View article: Constrained motion design with distinct actuators and motion stabilization
Constrained motion design with distinct actuators and motion stabilization Open
The design of adaptive structures is one method to improve sustainability of buildings. Adaptive structures are able to adapt to different loading and environmental conditions or to changing requirements by either small or large shape chan…
View article: Constrained motion design with distinct actuators and motion\n stabilization
Constrained motion design with distinct actuators and motion\n stabilization Open
The design of adaptive structures is one method to improve sustainability of\nbuildings. Adaptive structures are able to adapt to different loading and\nenvironmental conditions or to changing requirements by either small or large\nshape c…
View article: Artificial intelligence facilitates decision-making in the treatment of lumbar disc herniations
Artificial intelligence facilitates decision-making in the treatment of lumbar disc herniations Open
Purpose Apart from patients with severe neurological deficits, it is not clear whether surgical or conservative treatment of lumbar disc herniations is superior for the individual patient. We investigated whether deep learning techniques c…
View article: A Case Study on Design and Optimization of Adaptive Civil Structures
A Case Study on Design and Optimization of Adaptive Civil Structures Open
Taking advantage of adaptivity in the field of civil engineering is a subject of ongoing research. Integration of adaptive elements in load-bearing structures is already well-established in many other engineering fields, albeit mostly for …
View article: Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry
Supersensitive Multifluorophore RNA‐FISH for Early Virus Detection and Flow‐FISH by Using Click Chemistry Open
The reliable detection of transcription events through the quantification of the corresponding mRNA is of paramount importance for the diagnostics of infections and diseases. The quantification and localization analysis of the transcripts …
View article: Concealed Intradural Disc Herniation: A Case Report
Concealed Intradural Disc Herniation: A Case Report Open
Introduction: We present a case of a concealed intradural lumbar disc herniation following a previous discectomy with adhesions of the ventral dura to the posterior longitudinal ligament.
View article: Optimal Design of Adaptive Structures vs. Optimal Adaption of Structural Design
Optimal Design of Adaptive Structures vs. Optimal Adaption of Structural Design Open
Taking advantage of adaptivity in the field of civil engineering is an ongoing research topic. Integration of adaptive elements in the load-bearing structure is already well established in many other engineering fields. First investigation…
View article: Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels Open
Cancer cell migration is influenced by cellular phenotype and behavior as well as by the mechanical and chemical properties of the environment. Furthermore, many cancer cells show plasticity of their phenotype and adapt it to the propertie…
View article: Open versus minimally invasive TLIF: literature review and meta-analysis
Open versus minimally invasive TLIF: literature review and meta-analysis Open
MITLIF and OTLIF provide equivalent long-term clinical outcomes. MITLIF had less tissue injury, blood loss, and length of hospital stay. MITLIF is also a safe alternative in obese patients and, in experienced hands, can also be used safely…
View article: Frontmatter
Frontmatter Open
View article: Dendrimer‐Based Signal Amplification of Click‐Labelled DNA in Situ
Dendrimer‐Based Signal Amplification of Click‐Labelled DNA in Situ Open
The in vivo incorporation of alkyne‐modified bases into the genome of cells is today the basis for the efficient detection of cell proliferation. Cells are grown in the presence of ethinyl‐dU (EdU), fixed and permeabilised. The incorporate…
View article: Ein bildgebendes Quantenkaskadenlaser-Spektrometer zur intraoperativen Gewebedifferenzierung in der chirurgischen Onkologie
Ein bildgebendes Quantenkaskadenlaser-Spektrometer zur intraoperativen Gewebedifferenzierung in der chirurgischen Onkologie Open
Zentrales Ziel der chirurgischen Onkologie ist i. d. R. die vollständige Entfernung (Resektion) eines Tumors, um Rückfälle (Rezidive) zu vermeiden. Tumoren werden daher in den moisten Fällen mit ausreichendem Sicherheitsabstand im gesunden…