Florian Grimm
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View article: The Silent Transformation of Stereotactic Brain Biopsies After the Introduction of Robotics
The Silent Transformation of Stereotactic Brain Biopsies After the Introduction of Robotics Open
Background In frame‐based stereotaxy, the design of the frame limits trajectory selection, e.g., to the temporal lobe and posterior fossa. We hypothesise that frame‐less neuronavigation and robotic technology might have expanded these ster…
View article: Comparison of 1D and 3D volume measurement techniques in NF2-associated vestibular schwannoma monitoring
Comparison of 1D and 3D volume measurement techniques in NF2-associated vestibular schwannoma monitoring Open
To compare 1D (linear) tumor volume calculations and classification systems with 3D-segmented volumetric analysis (SVA), focusing specifically on their effectiveness in the evaluation and management of NF2-associated vestibular schwannomas…
View article: Strong connectivity to the sensorimotor cortex predicts clinical effectiveness of thalamic deep brain stimulation in essential tremor
Strong connectivity to the sensorimotor cortex predicts clinical effectiveness of thalamic deep brain stimulation in essential tremor Open
Clinical effectiveness of DBS for ET corresponded to a distributed connectivity profile, with the connection to the sensorimotor cortex being most relevant. Long-term follow-up in larger cohorts and replication in out-of-sample data are ne…
View article: Perioperative Observations and Outcome in Surgical Treatment of Malignant Peripheral Nerve Sheath Tumors
Perioperative Observations and Outcome in Surgical Treatment of Malignant Peripheral Nerve Sheath Tumors Open
Background/Objectives: This retrospective observational study aimed to investigate the perioperative outcome in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) with and without relation to Neurofibromatosis Type 1 (NF1) and to detect pos…
View article: Robot‐assisted stereoencephalography vs subdural electrodes in the evaluation of temporal lobe epilepsy
Robot‐assisted stereoencephalography vs subdural electrodes in the evaluation of temporal lobe epilepsy Open
Objective Invasive video‐electroencephalography (iVEEG) is the gold standard for evaluation of refractory temporal lobe epilepsy before second stage resective surgery (SSRS). Traditionally, the presumed seizure onset zone (SOZ) has been co…
View article: Surgical Treatment of Craniopharyngiomas in Adults: Comparison between Primary Surgery and Surgery for Recurrence
Surgical Treatment of Craniopharyngiomas in Adults: Comparison between Primary Surgery and Surgery for Recurrence Open
Objective Few studies have investigated the differences in outcomes between primary and repeat surgery for a craniopharyngioma in adults. As a result, a treatment concept for adult patients with a craniopharyngioma has not yet been establi…
View article: The importance of MRI quality and reader’s experience for detecting an adenoma in Cushing’s disease
The importance of MRI quality and reader’s experience for detecting an adenoma in Cushing’s disease Open
Objective In Cushing’s disease (CD), detection of an adenoma by MRI is challenging. The aim of this study is to compare real-life MRI in the initial diagnostic workup of CD with high-quality MRI performed in a tertiary center for pituitary…
View article: Design and Evaluation of a Custom-Made Electromyographic Biofeedback System for Facial Rehabilitation
Design and Evaluation of a Custom-Made Electromyographic Biofeedback System for Facial Rehabilitation Open
Background In the rehabilitation of postoperative facial palsy, physical therapy is of paramount importance. However, in the early rehabilitation phase, voluntary movements are often limited, and thus, the motivation of patients is impacte…
View article: Patient‐to‐robot registration: The fate of robot‐assisted stereotaxy
Patient‐to‐robot registration: The fate of robot‐assisted stereotaxy Open
Background Robot‐assisted stereotaxy (RAS) promises higher stereotactic accuracy (SA) and time efficiency (TE) than frame‐based stereotaxy. However, both aspects are attributed to the problem of patient‐to‐robot registration. Objective To …
View article: Framed and non‐framed robotics in neurosurgery: A 10‐year single‐center experience
Framed and non‐framed robotics in neurosurgery: A 10‐year single‐center experience Open
Background Safety, efficacy and efficiency of neurosurgical robots are defined by their design (i.e., framed and non‐framed) and procedural workflow (PW) (from image to surgery). The present study describes the quality indicators of three …
View article: Frame-based and robot-assisted insular stereo-electroencephalography via an anterior or posterior oblique approach
Frame-based and robot-assisted insular stereo-electroencephalography via an anterior or posterior oblique approach Open
OBJECTIVE There is an increasing interest in stereo-electroencephalography (SEEG) for invasive evaluation of insular epilepsy. The implantation of insular SEEG electrodes, however, is still challenging due to the anatomical location and co…
View article: Risk Stratification for Immediate Postoperative Hearing Loss by Preoperative BAER (Brainstem Auditory Evoked Response) and Audiometry in NF2-Associated Vestibular Schwannomas
Risk Stratification for Immediate Postoperative Hearing Loss by Preoperative BAER (Brainstem Auditory Evoked Response) and Audiometry in NF2-Associated Vestibular Schwannomas Open
Both brainstem auditory evoked potentials (BAEP) and audiometry play a crucial role in neuro-oncological treatment decisions in Neurofibromatosis Type 2 associated (NF2) vestibular schwannoma (VS) as hearing preservation is the major goal.…
View article: Surgical management of choroid plexus papilloma of the cerebellopontine and cerebellomedullary angle: classification and strategy
Surgical management of choroid plexus papilloma of the cerebellopontine and cerebellomedullary angle: classification and strategy Open
Choroid plexus papillomas (CPPs) are primary neuroectodermal neoplasms that usually arise in the fourth ventricle in adults. In this study, we present 12 patients with CPP arising from the cerebellopontine angle (CPP-CPA) and/or of the cer…
View article: Clinical validation of kinematic assessments of post-stroke upper limb movements with a multi-joint arm exoskeleton
Clinical validation of kinematic assessments of post-stroke upper limb movements with a multi-joint arm exoskeleton Open
BACKGROUND: The clinical evaluation of the upper limb of severely impaired stroke patient is challenging. Sensor-based assessments may allow for an objective evaluation of this patient population. This study investigated the validity of a …
View article: Age at Onset and Presenting Symptoms of Neurofibromatosis Type 2 as Prognostic Factors for Clinical Course of Vestibular Schwannomas
Age at Onset and Presenting Symptoms of Neurofibromatosis Type 2 as Prognostic Factors for Clinical Course of Vestibular Schwannomas Open
The presenting symptoms of the tumor suppressor gene syndrome neurofibromatosis type 2 (NF2) are often non-specific and unrelated to the disease hallmark bilateral vestibular schwannomas (VS). However, age at onset and presenting symptoms …
View article: Clinical Validation of Kinematic Assessments of Post-Stroke Upper Limb Movements with a Multi-Joint Arm Exoskeleton
Clinical Validation of Kinematic Assessments of Post-Stroke Upper Limb Movements with a Multi-Joint Arm Exoskeleton Open
Background : Robotic and gravity-balancing exoskeletons, originally designed for the rehabilitation training of neurological patients, are now being increasingly applied in objective and fine-grained sensor-based assessments of upper limb …
View article: Occurrence and management of postoperative pneumocephalus using the semi-sitting position in vestibular schwannoma surgery
Occurrence and management of postoperative pneumocephalus using the semi-sitting position in vestibular schwannoma surgery Open
Background The semi-sitting position in neurosurgical procedures is still under debate due to possible complications such as venous air embolism (VAE) or postoperative pneumocephalus (PP). Studies reporting a high frequency of the latter r…
View article: Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy
Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy Open
This study demonstrated that temporal lobe channel theta-band desynchronization may be a predictive physiological hallmark of therapeutic response to ANT-DBS and may be used to improve the functional precision of this intervention by verif…
View article: Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis
Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis Open
The use of radiation treatment has increased for both sporadic and neurofibromatosis type 2 (NF2)-associated vestibular schwannoma (VS). However, there are a subset of radioresistant tumors and systemic treatments that are seldom used in t…
View article: Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients
Minimal Effect of Bevacizumab Treatment on Residual Vestibular Schwannomas after Partial Resection in Young Neurofibromatosis Type 2 Patients Open
Hearing-preserving partial resection of neurofibromatosis type 2 (NF2) associated vestibular schwannomas (VS) is a preferred treatment strategy, particularly for children and adolescents. However, the residual tumors do grow and lead at so…
View article: Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas
Impact of Surgery on Long-Term Results of Hearing in Neurofibromatosis Type-2 Associated Vestibular Schwannomas Open
Hearing preservation is a major goal in the treatment of neurofibromatosis type 2 (NF2) associated vestibular schwannoma (VS), particularly in children and adolescents. In this study, we retrospectively reviewed hearing and volumetry data …
View article: Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation
Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation Open
Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead t…
View article: Hybrid Neuroprosthesis for the Upper Limb: Combining Brain-Controlled Neuromuscular Stimulation with a Multi-Joint Arm Exoskeleton
Hybrid Neuroprosthesis for the Upper Limb: Combining Brain-Controlled Neuromuscular Stimulation with a Multi-Joint Arm Exoskeleton Open
Brain-machine interface-controlled (BMI) neurofeedback training aims to modulate cortical physiology and is applied during neurorehabilitation to increase the responsiveness of the brain to subsequent physiotherapy. In a parallel line of r…