Florian Kast
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FAP-retargeted Ad5 enables <i>in vivo</i> gene delivery to stromal cells in the tumor microenvironment Open
Fibroblast activation protein (FAP) is a cell surface serine protease that is highly expressed on reactive stromal fibroblasts, such as cancer-associated fibroblasts (CAFs), and generally absent in healthy adult tissues. FAP expression in …
Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapies Open
Based on the success of tumor-infiltrating lymphocytes (TIL)-based therapies, personalized adoptive cell therapies (ACT) targeting neoantigens have the potential to become a disruptive technology and lead to highly effective treatments for…
Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer Open
Drug-induced compensatory signaling and subsequent rewiring of the signaling pathways that support cell proliferation and survival promote the development of acquired drug resistance in tumors. Here, we sought to analyze the adaptive kinas…
Modification of the kinetic stability of immunoglobulin G by solvent additives Open
Biophysical properties of antibody-based biopharmaceuticals are a critical part of their release criteria. In this context, finding the appropriate formulation is equally important as optimizing their intrinsic biophysical properties throu…
Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering Open
Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life‐threatening diseases. For their successful application in the clinic and a favorable cost‐benefit ratio, the design…