Florian Kirchner
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View article: Abundant Yet Aberrant T Helper Cell Responses to <i>Candida albicans</i> Underlie Mucosal Candidiasis in Humans and Mice
Abundant Yet Aberrant T Helper Cell Responses to <i>Candida albicans</i> Underlie Mucosal Candidiasis in Humans and Mice Open
T helper cell subsets—Th1, Th2, and Th17—coordinate pathogen‐specific immune responses. Candida albicans ‐specific T cells include protective Th17 cells alongside other Th subsets. However, the role of alternative Th subsets remains unclea…
View article: Arthroscopic subscapularis repair using the subscapularis interlocking (SICK)-stitch technique leads to restoration of clinical function with low complication and revision rates
Arthroscopic subscapularis repair using the subscapularis interlocking (SICK)-stitch technique leads to restoration of clinical function with low complication and revision rates Open
Two years after arthroscopic SCP repair using the SICK-stitch technique, we observed excellent restoration of clinical function with low complication and revision rates. The SICK-stitch technique thus represents a good and reliable therape…
View article: CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections
CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections Open
Regulatory T cells (Tregs) prevent excessive immune responses and limit immune pathology upon infections. To fulfill this role in different immune environments elicited by different types of pathogens, Tregs undergo functional specializati…
View article: Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa Open
Keeping a stable equilibrium between the host and commensal microbes to which we are constantly exposed, poses a major challenge for the immune system. The host mechanisms that regulate homeostasis of the microbiota to prevent infection an…
View article: Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa Open
Raw data files linked to a manuscript published in Mucosal Immunology 2020 (accepted for publication on July 6th,.2020)
View article: Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa Open
Raw data files linked to a manuscript published in Mucosal Immunology 2020 (accepted for publication on July 6th,.2020)
View article: CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis Open
The rarity of primary angiitis of the central nervous system ( PACNS ) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain ( NFL ) concentrations in cerebrospinal fluid in a severely relapsin…
View article: The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation
The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation Open
View article: Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression
Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression Open
Controlled immune activation in response to commensal microbes is critical for the maintenance of stable colonization and prevention of microbial overgrowth on epithelial surfaces. Our understanding of the host mechanisms that regulate bac…
View article: Th17 Immunity during Oral Candida albicans Colonization
Th17 Immunity during Oral Candida albicans Colonization Open
View article: Common Features of Regulatory T Cell Specialization During Th1 Responses
Common Features of Regulatory T Cell Specialization During Th1 Responses Open
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is e…
View article: The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity
The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity Open
View article: Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis
Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis Open
Candida spp. can cause severe and chronic mucocutaneous and systemic infections in immunocompromised individuals. Protection from mucocutaneous candidiasis depends on T helper cells, in particular those secreting IL-17. The events regulati…