Florian Koehler
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View article: Adeno-associated viruses escort nanomaterials to specific cells and tissues
Adeno-associated viruses escort nanomaterials to specific cells and tissues Open
The delivery of nanotherapeutics to specific tissues relies on bespoke targeting strategies or invasive surgeries. Conversely, adeno-associated viruses (AAVs) can target specific tissues following intravenous injections. Here we show that …
View article: Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation
Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation Open
Deep brain stimulation with implanted electrodes has transformed neuroscience studies and treatment of neurological and psychiatric conditions. Discovering less invasive alternatives to deep brain stimulation could expand its clinical and …
View article: Magnetoelectric Nanodiscs Enable Wireless Transgene-Free Neuromodulation
Magnetoelectric Nanodiscs Enable Wireless Transgene-Free Neuromodulation Open
Deep-brain stimulation (DBS) with implanted electrodes revolutionized treatment of movement disorders and empowered neuroscience studies. Identifying less invasive alternatives to DBS may further extend its clinical and research applicatio…
View article: Magnetically Actuated Fiber‐Based Soft Robots
Magnetically Actuated Fiber‐Based Soft Robots Open
Broad adoption of magnetic soft robotics is hampered by the sophisticated field paradigms for their manipulation and the complexities in controlling multiple devices. Furthermore, high‐throughput fabrication of such devices across spatial …
View article: Modulating cell signalling in vivo with magnetic nanotransducers
Modulating cell signalling in vivo with magnetic nanotransducers Open
View article: Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation
Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation Open
Exposure to stressful or traumatic stimuli may alter hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) reactivity. This altered reactivity may be a component or cause of mental illnesses. Dissecting these mechan…
View article: Modular Integration of Hydrogel Neural Interfaces
Modular Integration of Hydrogel Neural Interfaces Open
Thermal drawing has been recently leveraged to yield multifunctional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility r…
View article: Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs
Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs Open
Exposure to stress alters hypothalamic-pituitary-adrenal (HPA) axis reactivity; however, it is unclear exactly how or where within the HPA pathway these changes occur. Dissecting these mechanisms requires tools to reliably probe HPA functi…
View article: Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions
Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions Open
Redox cofactors mediate many enzymatic processes and are increasingly employed in biomedical and energy applications. Exploring the influence of external magnetic fields on redox cofactor chemistry can enhance our understanding of magnetic…
View article: Modular Integration of Hydrogel Neural Interfaces
Modular Integration of Hydrogel Neural Interfaces Open
Thermal drawing has been recently leveraged to yield multi-functional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility …
View article: Modular Integration of Hydrogel Neural Interfaces
Modular Integration of Hydrogel Neural Interfaces Open
Thermal drawing has been recently leveraged to yield multi-functional, fiber-based neural probes at near kilometer length scales. Despite its promise, the widespread adoption of this approach has been impeded by (1) material compatibility …
View article: TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains Open
The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what chromatin changes are associated with TGFβ-dependent enhancers regulation …
View article: <i>In Vivo</i> Photopharmacology Enabled by Multifunctional Fibers
<i>In Vivo</i> Photopharmacology Enabled by Multifunctional Fibers Open
Photoswitchable ligands can add an optical switch to a target receptor or signaling cascade and enable reversible control of neural circuits. The application of this approach, termed photopharmacology, to behavioral experiments has been im…
View article: Remotely Controlled Proton Generation for Neuromodulation
Remotely Controlled Proton Generation for Neuromodulation Open
Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic field…
View article: In situ electrochemical generation of nitric oxide for neuronal modulation
In situ electrochemical generation of nitric oxide for neuronal modulation Open
View article: Remotely Controlled Proton Generation for Neuromodulation
Remotely Controlled Proton Generation for Neuromodulation Open
Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting non-invasive alternating magnetic fiel…
View article: Remotely Controlled Proton Generation for Neuromodulation
Remotely Controlled Proton Generation for Neuromodulation Open
Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting non-invasive alternating magnetic fiel…
View article: Transgene-free remote magnetothermal regulation of adrenal hormones
Transgene-free remote magnetothermal regulation of adrenal hormones Open
Remote magnetic modulation of adrenal cell calcium in the presence of nanoparticles enables on-demand hormone release.
View article: <i>In vivo</i>photopharmacology enabled by multifunctional fibers
<i>In vivo</i>photopharmacology enabled by multifunctional fibers Open
To reversibly manipulate neural circuits with increased spatial and temporal control, photoswitchable ligands can add an optical switch to a target receptor or signaling cascade. This approach, termed photopharmacology, has been enabling t…