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View article: 82. Comparative Evaluation of Low Versus High Doses of Rifampin for the Treatment of Staphylococcal Bone and Joint Infections: an open-label, randomized, controlled non-inferiority trial (EVRIOS)
82. Comparative Evaluation of Low Versus High Doses of Rifampin for the Treatment of Staphylococcal Bone and Joint Infections: an open-label, randomized, controlled non-inferiority trial (EVRIOS) Open
Background The antibiotic management of staphylococcal bone and joint infection usually relies on rifampin associated with another antibiotic for susceptible strains. The appropriate dose of rifampin remains unclear and diverges in interna…
View article: Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Open
The Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology established the second consensus report to guide therapeutic drug monitoring (TDM) of everolimus (EVR)…
View article: Questioning the Design of Non‐Inferiority Trials: The Strange Case for Therapeutic Drug Monitoring Absence in Phase <scp>III</scp> Trials
Questioning the Design of Non‐Inferiority Trials: The Strange Case for Therapeutic Drug Monitoring Absence in Phase <span>III</span> Trials Open
International audience
View article: A biological pharmacology network to secure the risk of drug–drug interaction with nirmatrelvir/ritonavir
A biological pharmacology network to secure the risk of drug–drug interaction with nirmatrelvir/ritonavir Open
View article: Voriconazole as an alternative oral treatment in fluconazole-resistant urinary candidiasis
Voriconazole as an alternative oral treatment in fluconazole-resistant urinary candidiasis Open
The urinary diffusion of voriconazole resulted in drug exposure above the target minimum inhibitory concentration (MIC) in the five patients treated for voriconazole-susceptible Candida strains in urine. Therapeutic drug monitoring may all…
View article: Therapeutic drug monitoring in kidney and liver transplantation: current advances and future directions
Therapeutic drug monitoring in kidney and liver transplantation: current advances and future directions Open
To improve the care of transplant patients, several TDM innovations can be pursued by investigators. Among these, the development of microsampling methods for TDM or the combination of pharmacodynamic biomarkers with ISD exposure measureme…
View article: Adaptative Strategy of Immunosuppressive Drugs Dosage Adjustments When Combined With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients With COVID-19
Adaptative Strategy of Immunosuppressive Drugs Dosage Adjustments When Combined With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients With COVID-19 Open
Nirmatrelvir/ritonavir is a promising option for preventing severe COVID-19 in solid organ transplant recipients with SARS-CoV-2 infection. However, concerns have arisen regarding potential drug interactions with calcineurin inhibitors (CN…
View article: Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury
Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury Open
A 56‐year‐old woman was transferred to the intensive care unit (ICU) two days after an allogeneic stem cell transplantation (ASCT) when she presented acute respiratory distress due to the relapse of a SARS‐CoV‐2 infection. Following that, …
View article: Are we done with Hydroxychloroquine for COVID-19? Studies with ethical, legal, and methodological concerns must now be retracted
Are we done with Hydroxychloroquine for COVID-19? Studies with ethical, legal, and methodological concerns must now be retracted Open
On October 30th, a new study from the Institut Hospitalo-Universitaire Méditerranée Infection (IHU-MI) was published in the journal “New Microbes and New Infections” [1]. This is the latest publication in a long series that is controversia…
View article: Pharmacokinetics of baricitinib in critically ill COVID-19 patients
Pharmacokinetics of baricitinib in critically ill COVID-19 patients Open
View article: Amoxicillin-Induced Neurotoxicity: Contribution of a Healthcare Data Warehouse to the Determination of a Toxic Concentration Threshold
Amoxicillin-Induced Neurotoxicity: Contribution of a Healthcare Data Warehouse to the Determination of a Toxic Concentration Threshold Open
Background: Amoxicillin (AMX)-induced neurotoxicity is well described and may be associated with AMX overexposure. No neurotoxic concentration threshold has been determined thus far. A better knowledge of maximum tolerable AMX concentratio…
View article: Optical flow algorithms optimized for speed, energy and accuracy on embedded GPUs
Optical flow algorithms optimized for speed, energy and accuracy on embedded GPUs Open
View article: Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022
Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022 Open
View article: The concomitant use of proton pump inhibitors and BRAF/MEK inhibitors in metastatic melanoma
The concomitant use of proton pump inhibitors and BRAF/MEK inhibitors in metastatic melanoma Open
Background Proton-pump inhibitors (PPIs) are commonly used by patients with cancer, although they could reduce the absorption of oral anticancer targeted therapies. The US Food and Drug Administration states that the effect of PPIs on the …
View article: Lactic acidosis after allogeneic haematopoietic stem cell transplantation potentially related to letermovir
Lactic acidosis after allogeneic haematopoietic stem cell transplantation potentially related to letermovir Open
A 53‐year‐old woman with a history of acute myeloid leukaemia received a second allogeneic haematopoietic stem cell transplant and was prescribed, among other medications, acyclovir and letermovir (480‐mg daily oral dose) for prophylaxis o…
View article: A pharmacist-led intervention to improve kidney transplant recipient outcomes and identify patients at risk of highly variable trough tacrolimus levels: a cohort study
A pharmacist-led intervention to improve kidney transplant recipient outcomes and identify patients at risk of highly variable trough tacrolimus levels: a cohort study Open
Pharmacist-led interventions may have contributed to improved graft survival and patient management of immunosuppressants. Because %CV correlates with the patient questionnaire score, its introduction could be useful in identifying kidney …
View article: Contribution of voriconazole N‐oxide plasma concentration measurements to voriconazole therapeutic drug monitoring in patients with invasive fungal infection
Contribution of voriconazole N‐oxide plasma concentration measurements to voriconazole therapeutic drug monitoring in patients with invasive fungal infection Open
Background Voriconazole (VRC), a widely used triazole antifungal, exhibits significant inter‐ and intra‐individual pharmacokinetic variability. The main metabolite voriconazole N‐oxide (NOX) can provide information on the patient's drug me…
View article: A Case Report of Safe Coadministration of Amiodarone with Short‐Term Treatment Nirmatrelvir‐Ritonavir
A Case Report of Safe Coadministration of Amiodarone with Short‐Term Treatment Nirmatrelvir‐Ritonavir Open
International audience
View article: LACTIC ACIDOSIS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION AND POSSIBLE INFLUENCE OF ANTIVIRAL DRUGS
LACTIC ACIDOSIS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION AND POSSIBLE INFLUENCE OF ANTIVIRAL DRUGS Open
A 53-year-old woman with a history of acute myeloid leukemia received a second allogenic hematopoietic stem cell transplant (HSCT) and was prescribed, among other medications, acyclovir and letermovir (480 mg daily oral dose) for prophylax…
View article: Antimicrobial Exposure: Do Not Forget the Patient’s Condition Beneath the Extracorporeal Membrane Oxygenation Support!
Antimicrobial Exposure: Do Not Forget the Patient’s Condition Beneath the Extracorporeal Membrane Oxygenation Support! Open
International audience
View article: Therapeutic drug monitoring in oncology - What’s out there: A bibliometric evaluation on the topic
Therapeutic drug monitoring in oncology - What’s out there: A bibliometric evaluation on the topic Open
Pharmacological therapy is the mainstay of treatment for cancer patients. Despite wide interpatient variability in systemic drug concentrations for numerous antineoplastics, dosing based on body size remains the predominant approach. Thera…
View article: Première expérience de suivi thérapeutique pharmacologique du tacrolimus en greffe rénale associé au nirmatrelvir/ritonavir : comment le micro-échantillonnage est devenu incontournable pour le suivi des patients transplantés
Première expérience de suivi thérapeutique pharmacologique du tacrolimus en greffe rénale associé au nirmatrelvir/ritonavir : comment le micro-échantillonnage est devenu incontournable pour le suivi des patients transplantés Open
INTRODUCTION: Le nirmatrelvir/ritonavir est un traitement indiqué dans la prévention des formes sévères de COVID-19. À ce jour, peu d’expériences ont été rapportées chez les patients transplantés rénaux en raison du risque d’interactions m…
View article: 449TiP Evaluation of regorafenib treatment PERSOnalization based on therapeutic drug monitoring in patients with metastatic colorectal cancer (mCRC): RePERSO study
449TiP Evaluation of regorafenib treatment PERSOnalization based on therapeutic drug monitoring in patients with metastatic colorectal cancer (mCRC): RePERSO study Open
View article: Safety, Efficacy, and Relapse of Nirmatrelvir-Ritonavir in Kidney Transplant Recipients Infected With SARS-CoV-2
Safety, Efficacy, and Relapse of Nirmatrelvir-Ritonavir in Kidney Transplant Recipients Infected With SARS-CoV-2 Open
NR can be used in KTRs but requires a strict protocol of drug adaptation. We observed 2 cases of early relapse after NR treatment that need further investigations.
View article: Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study
Blood, Cellular, and Tissular Calcineurin Inhibitors Pharmacokinetic–Pharmacodynamic Relationship in Heart Transplant Recipients: The INTRACAR Study Open
Background: After heart transplantation, calcineurin inhibitors (CNI) (cyclosporin A and tacrolimus) are key immunosuppressive drugs to prevent graft rejection. Whole-blood concentration (C blood )-guided therapeutic drug monitoring (TDM) …
View article: Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19
Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19 Open
Nirmatrelvir/ritonavir (Paxlovid) consists of a peptidomimetic inhibitor (nirmatrelvir) of the SARS-CoV-2 main protease and a pharmacokinetic enhancer (ritonavir). It is approved for the treatment of mild-to-moderate COVID-19. This combina…
View article: Yes We Can (Use Nirmatrelvir/Ritonavir Even in High Immunological Risk Patients Treated with Immunosuppressive Drugs)!
Yes We Can (Use Nirmatrelvir/Ritonavir Even in High Immunological Risk Patients Treated with Immunosuppressive Drugs)! Open
View article: LSL3D : Etiquetage en Composantes Connexe par segments pour volumes 3D
LSL3D : Etiquetage en Composantes Connexe par segments pour volumes 3D Open
International audience
View article: Quantification of Infliximab and Adalimumab in Human Plasma by a Liquid Chromatography Tandem Mass Spectrometry Kit and Comparison with Two ELISA Methods
Quantification of Infliximab and Adalimumab in Human Plasma by a Liquid Chromatography Tandem Mass Spectrometry Kit and Comparison with Two ELISA Methods Open
Background: This study compared the performance of plasma infliximab and adalimumab quantification using a commercially available kit (mAbXmise kit) and mass spectrometry readout to that of two ELISA methods in patients treated for …
View article: LSL3D: a run-based Connected Component Labeling algorithm for 3D volumes
LSL3D: a run-based Connected Component Labeling algorithm for 3D volumes Open
International audience