Florian A. Mann
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View article: Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments
Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments Open
The use of lipid nanoparticles (LNPs) for therapeutic RNA delivery has gained significant interest, particularly highlighted by recent milestones such as the approval of Onpattro and two mRNA-based SARS-CoV-2 vaccines. However, despite sub…
View article: A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution
A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution Open
Significance The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed understanding of how dopamine release and signaling are regulated at the subcellu…
View article: Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer’s Disease
Molecular Profiles of Amyloid-β Proteoforms in Typical and Rapidly Progressive Alzheimer’s Disease Open
The molecular determinants of atypical clinical variants of Alzheimer’s disease, including the recently discovered rapidly progressive Alzheimer’s disease (rpAD), are unknown to date. Fibrilization of the amyloid-β (Aβ) peptide is the most…
View article: Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies
Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies Open
Single wall carbon nanotubes (SWCNT) fluoresce in the near infrared (NIR) and have been assembled with biopolymers such as DNA to form highly sensitive molecular sensors. They change their fluorescence when they interact with analytes. Des…
View article: Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies
Quantum Defects in Fluorescent Carbon Nanotubes for Sensing and Mechanistic Studies Open
Single wall carbon nanotubes (SWCNT) fluoresce in the near infrared (NIR) and have been assembled with biopolymers such as DNA to form highly sensitive molecular sensors. They change their fluorescence when they interact with analytes. Des…
View article: A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites
A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites Open
The neurotransmitter dopamine is released from discrete axonal structures called varicosities. Its release is essential in behaviour and is critically implicated in prevalent neuropsychiatric diseases. Existing dopamine detection methods a…
View article: Figures-data.zip
Figures-data.zip Open
raw data underlying the publication "Quantum defects as versatile anchors for carbon nanotube functionalization"
View article: Inside Cover: Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins (Angew. Chem. Int. Ed. 40/2020)
Inside Cover: Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins (Angew. Chem. Int. Ed. 40/2020) Open
sp3 quantum defects can be used for covalent functionalization of single-walled carbon nanotubes (SWCNTs) under preservation of their near-infrared (NIR) fluorescence. In their Research Article on page 17732, S. Kruss and co-workers descri…
View article: Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins
Quantum Defects as a Toolbox for the Covalent Functionalization of Carbon Nanotubes with Peptides and Proteins Open
Single‐walled carbon nanotubes (SWCNTs) are a 1D nanomaterial that shows fluorescence in the near‐infrared (NIR, >800 nm). In the past, covalent chemistry was less explored to functionalize SWCNTs as it impairs NIR emission. However, certa…
View article: Near-Infrared Imaging of Serotonin Release from Cells with Fluorescent Nanosensors
Near-Infrared Imaging of Serotonin Release from Cells with Fluorescent Nanosensors Open
Serotonin is an important neurotransmitter involved in various functions of the nervous, blood, and immune system. In general, detection of small biomolecules such as serotonin in real time with high spatial and temporal resolution remains…
View article: Chemical Imaging with Fluorescent Nanosensors
Chemical Imaging with Fluorescent Nanosensors Open
Chemical imaging is a powerful technique and provides spatial and temporal chemical information of a sample. Examples include direct methods such as Raman spectroscopy-based imaging or mass spectrometry imaging. In contrast, many imaging m…
View article: Transport and programmed release of nanoscale cargo from cells by using NETosis
Transport and programmed release of nanoscale cargo from cells by using NETosis Open
Immune cells take up nanoscale materials and can be programmed to release it again, which has important implications for understanding cellular functions, biocompatibility as well as biomedical applications.
View article: Design strategies for carbon nanotube-based biosensors
Design strategies for carbon nanotube-based biosensors Open
Globale Gesundheitskrisen wie die COVID-19-Pandemie zeigen deutlich den Bedarf an neuartigen und besseren diagnostischen und therapeutischen Instrumenten. Darüber hinaus ist das Verständnis der zugrunde liegenden molekularen Prozesse von e…
View article: Programmed transport and release of nanoscale cargo by immune cells
Programmed transport and release of nanoscale cargo by immune cells Open
Transport and delivery of (nanoscale) materials are crucial for many applications in biomedicine. However, controlled uptake, transport and triggered release of such cargo remains challenging. In this study, we use human immune cells (neut…
View article: Exfoliated near infrared fluorescent CaCuSi<sub>4</sub>O<sub>10</sub> nanosheets with ultra-high photostability and brightness for biological imaging
Exfoliated near infrared fluorescent CaCuSi<sub>4</sub>O<sub>10</sub> nanosheets with ultra-high photostability and brightness for biological imaging Open
Imaging of complex (biological) samples in the near infrared (nIR) range of the spectrum is beneficial due to reduced light scattering, absorption, phototoxicity and autofluorescence. However, there are only few near infrared fluorescent m…
View article: Nanobody‐Conjugated Nanotubes for Targeted Near‐Infrared In Vivo Imaging and Sensing
Nanobody‐Conjugated Nanotubes for Targeted Near‐Infrared In Vivo Imaging and Sensing Open
Fluorescent nanomaterials such as single‐walled carbon nanotubes (SWCNTs) have many advantages in terms of their photophysics, but it is difficult to target them to specific locations in living systems. In contrast, the green fluorescent p…
View article: Quantification of the Number of Adsorbed DNA Molecules\non Single-Walled Carbon Nanotubes
Quantification of the Number of Adsorbed DNA Molecules\non Single-Walled Carbon Nanotubes Open
Single-walled\ncarbon nanotubes (SWCNTs) have unique photophysical\nproperties and promise many novel applications. Their functionalization\nis crucial, but the organic phase around SWCNTs is poorly understood.\nNoncovalent functionalizati…
View article: Chirality enriched carbon nanotubes with tunable wrapping <i>via</i> corona phase exchange purification (CPEP)
Chirality enriched carbon nanotubes with tunable wrapping <i>via</i> corona phase exchange purification (CPEP) Open
A novel process (CPEP) for chirality enriched single-walled carbon nanotubes with tunable functionalization.
View article: Cover Feature: Carbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels (Chem. Eur. J. 47/2018)
Cover Feature: Carbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels (Chem. Eur. J. 47/2018) Open
Encapsulation of single-walled carbon nanotubes (SWCNT) by α-helical coiled-coil peptide barrels (αHBs) offers a novel approach to solubilize and functionalize the surface of near-infrared fluorescent SWCNTs. Optical spectroscopy and atomi…
View article: Tuning Selectivity of Fluorescent Carbon Nanotube-Based Neurotransmitter Sensors
Tuning Selectivity of Fluorescent Carbon Nanotube-Based Neurotransmitter Sensors Open
Detection of neurotransmitters is an analytical challenge and essential to understand neuronal networks in the brain and associated diseases. However, most methods do not provide sufficient spatial, temporal, or chemical resolution. Near-i…