Florian Selinger
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View article: A cost-effective vessel-on-a-chip for high shear stress applications in vascular biology
A cost-effective vessel-on-a-chip for high shear stress applications in vascular biology Open
The vascular endothelium is constantly subjected to hemodynamic forces, including tangential shear stress, which are crucial for maintaining vascular homeostasis. Pathological shear stress levels, such as those observed in pulmonary arteri…
View article: Characterization and optimization of a quantitative colorimetric acetylcholine esterase inhibition assay for biochip integration demonstrated by neurotoxicity evaluation of malathion
Characterization and optimization of a quantitative colorimetric acetylcholine esterase inhibition assay for biochip integration demonstrated by neurotoxicity evaluation of malathion Open
Organophosphates (OPs) and carbamates as insecticides, nematicides, fungicides, and herbicides are constantly increasing. Their neurotoxic nature requires careful usage, and misuse can lead to fatalities. OPs classified as 'Class 1' toxic …
View article: Using Rapid Prototyping to Develop a Cell-Based Platform with Electrical Impedance Sensor Membranes for In Vitro RPMI2650 Nasal Nanotoxicology Monitoring
Using Rapid Prototyping to Develop a Cell-Based Platform with Electrical Impedance Sensor Membranes for In Vitro RPMI2650 Nasal Nanotoxicology Monitoring Open
Due to advances in additive manufacturing and prototyping, affordable and rapid microfluidic sensor-integrated assays can be fabricated using additive manufacturing, xurography and electrode shadow masking to create versatile platform tech…
View article: Application of a Biomimetic Nanoparticle-Based Mock Virus to Determine SARS-CoV-2 Neutralizing Antibody Levels in Blood Samples Using a Lateral Flow Assay
Application of a Biomimetic Nanoparticle-Based Mock Virus to Determine SARS-CoV-2 Neutralizing Antibody Levels in Blood Samples Using a Lateral Flow Assay Open
The presence of neutralizing antibodies against SARS-CoV-2 in blood, acquired through previous infection or vaccination, is known to prevent the (re)occurrence of outbreaks unless the virus mutates. Therefore, the measurement of neutralizi…
View article: Development of a Paper-based Hematocrit Test and a Lateral Flow Assay to Detect Critical Fibrinogen Concentrations Using a Bottom-Up Pyramid Workflow Approach
Development of a Paper-based Hematocrit Test and a Lateral Flow Assay to Detect Critical Fibrinogen Concentrations Using a Bottom-Up Pyramid Workflow Approach Open
Fibrinogen is a coagulation factor in human blood and the first one to reach critical levels in major bleeding. Hypofibrinogenemia (a too low fibrinogen concentration in blood) poses great challenges to first responders, clinicians, and he…
View article: A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine
A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine Open
A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.
View article: Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices
Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices Open
The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip device…
View article: A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties
A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties Open
Physiological‐relevant in vitro tissue models with their promise of better predictability have the potential to improve drug screening outcomes in preclinical studies. Despite the advances of spheroid models in pharmaceutical screening app…
View article: Cytotoxicity, Retention, and Anti-inflammatory Effects of a CeO<sub>2</sub> Nanoparticle-Based Supramolecular Complex in a 3D Liver Cell Culture Model
Cytotoxicity, Retention, and Anti-inflammatory Effects of a CeO<sub>2</sub> Nanoparticle-Based Supramolecular Complex in a 3D Liver Cell Culture Model Open
Both cerium oxide (CeOx) nanoparticles and mefenamic acid (MFA) are known anti-inflammatory agents with hepatoprotective properties and are therefore prescribed for one of the major diseases in the world, nonalcoholic fatty liver disease (…