Florian Singer
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View article: Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History Open
Background Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to devel…
View article: Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents: an observational prospective study
Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents: an observational prospective study Open
STUDY AIMS: Routinely collected health data are increasingly used for research; however important anamnestic details may be missing from medical records. We compared physician documentation of paediatric exercise-induced respiratory sympto…
View article: Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma
Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma Open
Background We have previously developed Core Outcome Measures sets for Severe Asthma (COMSA) by multi-stakeholder consensus. There are no patient-centred tools to quantify response to biological therapies for severe asthma. We aimed to dev…
View article: Air pollution exposure during pregnancy and lung function in childhood: The LUIS study
Air pollution exposure during pregnancy and lung function in childhood: The LUIS study Open
Background The adverse effects of high air pollution levels on childhood lung function are well‐known. Limited evidence exists on the effects of moderate exposure levels during early life on childhood lung function. We investigated the ass…
View article: Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents
Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents Open
Aims of the study Routinely collected health data are increasingly used for research, however important history items may be incomplete in medical records. We assessed clinical documentation of exercise-induced respiratory symptoms (EIS) b…
View article: Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study
Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study Open
Rationale: The early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognostic and d…
View article: Longitudinal assessment of lung function in Swiss childhood cancer survivors—A multicenter cohort study
Longitudinal assessment of lung function in Swiss childhood cancer survivors—A multicenter cohort study Open
Objective Childhood cancer survivors are at risk for pulmonary morbidity due to exposure to lung‐toxic treatments, including specific chemotherapeutics, radiotherapy, and surgery. Longitudinal data on lung function and its change over time…
View article: Predictors of asthma control differ from predictors of asthma attacks in children: The Swiss Paediatric Airway Cohort
Predictors of asthma control differ from predictors of asthma attacks in children: The Swiss Paediatric Airway Cohort Open
Background It is unclear if predictors of asthma attacks are the same as those of asthma symptom control in children. Objective We evaluated predictors for these two outcomes in a clinical cohort study. Methods The Swiss Paediatric Airway …
View article: Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk Open
Rationale: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. Objectives: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. Methods: Oroph…
View article: Definitions of non-response and response to biological therapy for severe asthma: a systematic review
Definitions of non-response and response to biological therapy for severe asthma: a systematic review Open
Background Biologics have proven efficacy for patients with severe asthma but there is lack of consensus on defining response. We systematically reviewed and appraised methodologically developed, defined and evaluated definitions of non-re…
View article: Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) Open
Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (…
View article: Normative multiple-breath washout data in school-aged children corrected for sensor error
Normative multiple-breath washout data in school-aged children corrected for sensor error Open
This study provides updated reference values for nitrogen multiple-breath washout outcomes in healthy, white, school-aged children in a commercially available device corrected for a known sensor error.https://bit.ly/3mzBoyR
View article: Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort
Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort Open
Background Exacerbation‐prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear. Objectives To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs…
View article: Predictors of asthma control differ from predictors of asthma attacks in children: the Swiss Paediatric Airway Cohort
Predictors of asthma control differ from predictors of asthma attacks in children: the Swiss Paediatric Airway Cohort Open
Background It is unclear if predictors of asthma attacks are the same as those of asthma symptom control in children. We evaluated predictors for these two outcomes in a clinical cohort study. Methods The Swiss Paediatric Airway Cohort (SP…
View article: Longitudinal assessment of lung function in Swiss childhood cancer survivors
Longitudinal assessment of lung function in Swiss childhood cancer survivors Open
Rationale Childhood cancer survivors (CCSs) are at increased risk for pulmonary morbidity due to exposure to lung-toxic treatments, including specific chemotherapies, radiotherapy, and surgery. Longitudinal data on lung function, with info…
View article: Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren
Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren Open
Background References from the Global Lung Function Initiative (GLI) are widely used to interpret children's spirometry results. We assessed fit for healthy schoolchildren. Methods LuftiBus in the School was a population-based cross-sectio…
View article: Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study
Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study Open
Introduction Asthma is a heterogeneous disease with poorly defined phenotypes. Patients with severe asthma often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it c…
View article: Age and body mass index affect fit of spirometry GLI references in schoolchildren
Age and body mass index affect fit of spirometry GLI references in schoolchildren Open
Background References from the Global Lung Function Initiative (GLI) are widely used to interpret children’s spirometry results. We assessed fit for healthy schoolchildren. Methods LuftiBus in the school (LUIS) is a population-based cross-…
View article: Agreement of parent‐ and child‐reported wheeze and its association with measurable asthma traits
Agreement of parent‐ and child‐reported wheeze and its association with measurable asthma traits Open
Objectives In epidemiological studies, childhood asthma is usually assessed with questionnaires directed at parents or children, and these may give different answers. We studied how well parents and children agreed when asked to report sym…
View article: LuftiBus in the school (LUIS): a population-based study on respiratory health in schoolchildren
LuftiBus in the school (LUIS): a population-based study on respiratory health in schoolchildren Open
Respiratory disease is common in children and strongly associated with lifestyle and environmental exposures. Thus, it is important to study the epidemiology locally. The LuftiBus in the School (LUIS) study was set up to assess the respira…
View article: Association of lung clearance index with survival in individuals with cystic fibrosis
Association of lung clearance index with survival in individuals with cystic fibrosis Open
Background The lung clearance index (LCI) assesses global ventilation inhomogeneity and is a sensitive biomarker of airway function in cystic fibrosis (CF) lung disease. We examined the association of LCI with the risk of death or lung tra…
View article: Association of lung clearance index with survival in individuals with cystic fibrosis
Association of lung clearance index with survival in individuals with cystic fibrosis Open
Background Lung clearance index (LCI) quantifies global ventilation inhomogeneity, a sensitive biomarker of airway function in cystic fibrosis (CF) lung disease. Objectives We examined the association of LCI with the risk of death or lung …
View article: Agreement of parent- and child-reported wheeze: are they associated with FeNO and lung function?
Agreement of parent- and child-reported wheeze: are they associated with FeNO and lung function? Open
In epidemiological studies, childhood asthma is usually assessed with questionnaires directed at parents or children, and these may give different answers. We studied how well parents and children agreed when asked to report symptoms of wh…