Florian Strobl
YOU?
Author Swipe
View article: Application of tensile load at the tympanic membrane by an eardrum-contact transducer
Application of tensile load at the tympanic membrane by an eardrum-contact transducer Open
Safety of hearing devices attached to the tympanic membrane depends on applied forces and resulting movements of the ossicles when pulling off the device. A robotized temporal bone measurement setup was designed to apply and measure define…
View article: Sulfate limitation increases specific plasmid DNA yield and productivity in<i>E. coli</i>fed-batch processes
Sulfate limitation increases specific plasmid DNA yield and productivity in<i>E. coli</i>fed-batch processes Open
Plasmid DNA (pDNA) is a key biotechnological product whose importance became apparent in the last years due to its role as a raw material in the messenger ribonucleic acid (mRNA) vaccine manufacturing process. In pharmaceutical production …
View article: Bioprocess characterization of virus‐like particle production with the insect cell baculovirus expression system at nanoparticle level
Bioprocess characterization of virus‐like particle production with the insect cell baculovirus expression system at nanoparticle level Open
Background. Virus‐like particles (VLPs) are a multivalent platform showing great promise for the development of vaccines, gene therapy, diagnostic, and drug delivery approaches. Particularly, HIV‐1 Gag VLPs provide a robust and flexible sc…
View article: Clinical pilot study of the Vibrosonic hearing contact lens
Clinical pilot study of the Vibrosonic hearing contact lens Open
Introduction The Vibrosonic Hearing Contact Lens is the world's first hearing aid speaker manufactured using microsystem technology and placed directly on the eardrum. Recently, the Vibrosonic alpha was approved as the first solution bas…
View article: High shear resistance of insect cells: the basis for substantial improvements in cell culture process design
High shear resistance of insect cells: the basis for substantial improvements in cell culture process design Open
Multicellular organisms cultivated in continuous stirred tank reactors (CSTRs) are more sensitive to environmental conditions in the suspension culture than microbial cells. The hypothesis, that stirring induced shear stress is the main pr…
View article: A comprehensive antigen production and characterization study for easy-to-implement, highly specific and quantitative SARS-CoV-2 antibody assays
A comprehensive antigen production and characterization study for easy-to-implement, highly specific and quantitative SARS-CoV-2 antibody assays Open
Antibody tests are essential tools to investigate humoral immunity following SARS-CoV-2 infection. While first-generation antibody tests have primarily provided qualitative results with low specificity, accurate seroprevalence studies and …
View article: Reconsider the shear paradigm - stirring and aeration strategies in cell culture processes
Reconsider the shear paradigm - stirring and aeration strategies in cell culture processes Open
Multicellular organisms cultivated in continuously stirred tank reactors (CSTRs), are more sensitive to the environmental conditions prevalent in suspension culture than to bacteria. Stirring, mandatory for efficiently providing oxygen and…
View article: PEI-Mediated Transient Transfection of High Five Cells at Bioreactor Scale for HIV-1 VLP Production
PEI-Mediated Transient Transfection of High Five Cells at Bioreactor Scale for HIV-1 VLP Production Open
High Five cells are an excellent host for the production of virus-like particles (VLPs) with the baculovirus expression vector system (BEVS). However, the concurrent production of high titers of baculovirus hinder the purification of these…
View article: Evaluation of screening platforms for virus-like particle production with the baculovirus expression vector system in insect cells
Evaluation of screening platforms for virus-like particle production with the baculovirus expression vector system in insect cells Open
Recombinant protein and virus-like particle (VLP) production based on the baculovirus expression vector system is fast, flexible, and offers high yields. Independent from the product, a multitude of parameters are screened during process d…
View article: Off-target effects of an insect cell-expressed influenza HA-pseudotyped Gag-VLP preparation in limiting postinfluenza Staphylococcus aureus infections
Off-target effects of an insect cell-expressed influenza HA-pseudotyped Gag-VLP preparation in limiting postinfluenza Staphylococcus aureus infections Open
Clinical and historical data underscore the ability of influenza viruses to ally with Staphylococcus aureus and predispose the host for secondary bacterial pneumonia, which is a leading cause of influenza-associated mortality. This is fund…
View article: Correlation of <i>in vitro</i> cell adhesion, local shear flow and cell density
Correlation of <i>in vitro</i> cell adhesion, local shear flow and cell density Open
By combination of particle image velocimetry and live cell imaging in an acoustically driven microfluidic chamber, we study shear and cell density dependent adhesion. We find excellent agreement with simulations considering pure geometrica…
View article: Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip
Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip Open
Cell adhesion processes are of ubiquitous importance for biomedical applications such as optimization of implant materials. Here, not only physiological conditions such as temperature or pH, but also topographical structures play crucial r…