Florian Weisel
YOU?
Author Swipe
View article: Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states Open
View article: Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration Open
Summary Parkinson’s disease (PD) targets some dopamine (DA) neurons more than others. Sex differences offer insights, with females more protected from DA neurodegeneration. The mammalian vesicular glutamate transporter VGLUT2 and Drosophil…
View article: IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells Open
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6), markers of positive selection. How interleukin-21 (IL-21), a …
View article: Adenovirus-vectored SARS-CoV-2 vaccine expressing S1-N fusion protein
Adenovirus-vectored SARS-CoV-2 vaccine expressing S1-N fusion protein Open
Additional COVID-19 vaccines that are safe and immunogenic are needed for global vaccine equity. Here, we developed a recombinant type 5 adenovirus vector encoding for the SARS-CoV-2 S1 subunit antigen and nucleocapsid as a fusion protein …
View article: Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein
Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein Open
Additional COVID-19 vaccines that are safe, easy to manufacture, and immunogenic are needed for global vaccine equity. Here, we developed a recombinant type 5 adenovirus vector encoding for the SARS-CoV-2-S1 subunit antigen and nucleocapsi…
View article: Surface phenotypes of naive and memory B cells in mouse and human tissues
Surface phenotypes of naive and memory B cells in mouse and human tissues Open
View article: High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status
High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status Open
View article: A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice
A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice Open
Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for CO…
View article: Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype
Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotype Open
Although human B cells have been extensively studied, most reports have used peripheral blood as a source. Here, we used a unique tissue resource derived from healthy organ donors to deeply characterize human B-cell compartments across mul…
View article: Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis Open
View article: Liver Is a Generative Site for the B Cell Response to Ehrlichia muris
Liver Is a Generative Site for the B Cell Response to Ehrlichia muris Open
View article: B cell primary immune responses
B cell primary immune responses Open
B cell immune responses initiate after recognition of foreign or self antigen, often but not always in the context of an innate immune stimulus (eg, due to infection) or adjuvant (as in a vaccination). This process typically begins in B ce…
View article: B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells Open
View article: Memory B Cells of Mice and Humans
Memory B Cells of Mice and Humans Open
We comprehensively review memory B cells (MBCs), covering the definition of MBCs and their identities and subsets, how MBCs are generated, where they are localized, how they are maintained, and how they are reactivated. Whereas naive B cel…
View article: ZBTB32 Restricts the Duration of Memory B Cell Recall Responses
ZBTB32 Restricts the Duration of Memory B Cell Recall Responses Open
Memory B cell responses are more rapid and of greater magnitude than are primary Ab responses. The mechanisms by which these secondary responses are eventually attenuated remain unknown. We demonstrate that the transcription factor ZBTB32 …
View article: A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells Open