Florian Wunderer
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View article: HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype Open
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or …
View article: UBA6 and NDFIP1 regulate the degradation of ferroportin
UBA6 and NDFIP1 regulate the degradation of ferroportin Open
Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells. Binding of hepcidin to ferroportin induces the ubiquitination of ferroportin at multi…
View article: Do we visually estimate intra-operative blood loss better with white or green sponges and is the deviation from the real blood loss clinically acceptable? Results from a simulated scenario study
Do we visually estimate intra-operative blood loss better with white or green sponges and is the deviation from the real blood loss clinically acceptable? Results from a simulated scenario study Open
The deviation of correct blood loss estimation was smaller with white surgical sponges compared to green sponges. In general, deviations were so severe for both types of sponges, that it appears to be advisable to refrain from visually est…
View article: The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease
The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease Open
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is …
View article: The role of hepcidin and iron homeostasis in atherosclerosis
The role of hepcidin and iron homeostasis in atherosclerosis Open
View article: HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype Open
View article: Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity
Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity Open
Background: Human genetic variation in the NPR1 (natriuretic peptide receptor 1 gene, encoding NPR-A, atrial natriuretic peptide receptor 1) was recently shown to affect blood pressure (BP). NPR-A catalyzes the intracellular conversion of …
View article: Hepcidin Deficiency Protects Against Atherosclerosis
Hepcidin Deficiency Protects Against Atherosclerosis Open
Objective— Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum…
View article: Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency
Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency Open
View article: Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis
Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis Open
Background: The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. Methods: Skin biopsy specimens were obtained from…
View article: Supplementary Material for: Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis
Supplementary Material for: Increased Bone Morphogenetic Protein Signaling in the Cutaneous Vasculature of Patients with Calciphylaxis Open
Background: The objective of this study was to investigate the role of bone morphogenetic protein (BMP) signal transduction in the pathogenesis of calciphylaxis. Methods: Skin biopsy specimens were obtained from…