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View article: Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
DC increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Copper lowering drugs increased NK-mediated cell death in vitro
View article: Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model
View article: Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…
View article: Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Co-expression plots of VST-normalized gene expression profiles derived from TCGA datasets for PD-L1 and four copper-responsive genes
View article: Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Methods for Master Regulator Analysis
View article: Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability
View article: Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
DC increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Co-expression plots of VST-normalized gene expression profiles derived from TCGA datasets for PD-L1 and four copper-responsive genes
View article: Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…
View article: Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model
View article: Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability
View article: Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Copper lowering drugs increased NK-mediated cell death in vitro
View article: Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells
View article: Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells
View article: Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Methods for Master Regulator Analysis
View article: Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm
Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm Open
There is a pressing need to develop new antimicrobials to help combat the increase in antibiotic resistance that is occurring worldwide. In the current research, short amphiphilic antibacterial and antibiofilm agents were produced by tunin…
View article: Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…
View article: Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells
Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells Open
A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, qua…
View article: Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment
Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment Open
Selective vectorization of Cisplatin (CisPt) to Glioblastoma U87 cells was exploited by the fabrication of a hybrid nanocarrier composed of magnetic γ-Fe2O3 nanoparticles and nanographene oxide (NGO). The magnetic component, obtained by an…
View article: Graphene Oxide Functional Nanohybrids with Magnetic Nanoparticles for Improved Vectorization of Doxorubicin to Neuroblastoma Cells
Graphene Oxide Functional Nanohybrids with Magnetic Nanoparticles for Improved Vectorization of Doxorubicin to Neuroblastoma Cells Open
With the aim to obtain a site-specific doxorubicin (DOX) delivery in neuroblastoma SH-SY5Y cells, we designed an hybrid nanocarrier combining graphene oxide (GO) and magnetic iron oxide nanoparticles (MNPs), acting as core elements, and a …
View article: Harnessing copper in cancer to enhance anti-tumor immune response
Harnessing copper in cancer to enhance anti-tumor immune response Open
Background: Copper is elevated in tumors and the use of copper-chelating agents is under intense investigation. It has been reported that copper plays a key role in the immune system, but its activity is unclear. Recent advances in immunot…
View article: <i>In vivo</i> [<sup>64</sup>Cu]CuCl<sub>2</sub> PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis
<i>In vivo</i> [<sup>64</sup>Cu]CuCl<sub>2</sub> PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis Open
Given the strong clinical evidence that copper levels are significantly elevated in a wide spectrum of tumors, copper homeostasis is considered as an emerging target for anticancer drug design. Monitoring copper levels in vivo is therefore…