Floyd Silva
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View article: Targeting JunB Induces a Shift of Low- to High-thermogenic Adipocytes and Ameliorates Diet-induced Insulin Resistance
Targeting JunB Induces a Shift of Low- to High-thermogenic Adipocytes and Ameliorates Diet-induced Insulin Resistance Open
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue (BAT) heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its…
View article: Unusual presentation of idiopathic Bell’s palsy with involvement of the oculomotor nerve
Unusual presentation of idiopathic Bell’s palsy with involvement of the oculomotor nerve Open
Our patient presented with symptoms consistent with Bell’s palsy. The involved cranial nerves were the facial and oculomotor nerves. She had preceding upper respiratory tract infection symptoms. She had no risk factors or significant illne…
View article: Cutaneous hydrophilic polymer emboli following endovascular repair of an abdominal aortic aneurysm: a case and review of literature
Cutaneous hydrophilic polymer emboli following endovascular repair of an abdominal aortic aneurysm: a case and review of literature Open
Hydrophilic polymer embolism (HPE) is a rare iatrogenic complication of the use of polymer-coated intravascular devices, which may affect several organ systems including the skin. Herein, we present a patient who developed a cutaneous erup…
View article: Cerebral glucose metabolism in bipolar disorder: A voxel‐based meta‐analysis of positron emission tomography studies
Cerebral glucose metabolism in bipolar disorder: A voxel‐based meta‐analysis of positron emission tomography studies Open
Background Previous positron emission tomography studies have reported the changes of cerebral glucose metabolism in bipolar disorder. However, the findings across studies remain controversial, containing differing results. Methods A syste…
View article: Adipose mTORC1 suppresses prostaglandin signaling and beige adipogenesis via the CRTC2-COX-2 pathway
Adipose mTORC1 suppresses prostaglandin signaling and beige adipogenesis via the CRTC2-COX-2 pathway Open
(Cell Reports 24, 3180–3193; September 18, 2018) In the originally published version of this article, the Figure 3A legend incorrectly described the heatmap as summarizing differential gene expression in adenoid cystic carcinoma (ACC) tumo…
View article: Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling Open
ILC2s are present in adipose tissue and play a critical role in regulating adipose thermogenesis. However, the mechanisms underlying the activation of adipose-resident ILC2s remain poorly defined. Here, we show that IL-33, a potent ILC2 ac…
View article: Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism
Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism Open
ATG7: autophagy related 7; BAT: brown adipose tissue; CEBPB/C/EBPβ: CCAAT enhancer binding protein beta; DGAT1: diacylglycerol O-acyltransferase 1; eWAT: epididymal white adipose tissue; iWAT: inguinal white adipose tissue; KO: knockout; L…
View article: Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism
Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism Open
Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific rptor/raptor knockout (KO), atg7 KO and atg…
View article: Sustained Activation of Autophagy Suppresses Adipocyte Maturation via a Lipolysis-dependent Mechanism
Sustained Activation of Autophagy Suppresses Adipocyte Maturation via a Lipolysis-dependent Mechanism Open
Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific rptor/raptor knockout (KO), atg7 KO and atg…
View article: Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway Open
Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity. However, adipocyte-derived signals that act on progenitor cells to control beige …