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View article: Reconstructing Biological Molecules with Help from Video Gamers
Reconstructing Biological Molecules with Help from Video Gamers Open
Foldit is a citizen science video game in which players tackle a variety of complex biochemistry puzzles. Here, we describe a new series of puzzles in which Foldit players improve the accuracy of the public repository of experimental prote…
View article: Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders
Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders Open
Given the role of human intuition in current drug design efforts, crowd-sourced 'citizen scientist' games have the potential to greatly expand the pool of potential drug designers. Here, we introduce ‘Drugit', the small molecule design mod…
View article: Protein sequence design by explicit energy landscape optimization
Protein sequence design by explicit energy landscape optimization Open
The protein design problem is to identify an amino acid sequence which folds to a desired structure. Given Anfinsen’s thermodynamic hypothesis of folding, this can be recast as finding an amino acid sequence for which the lowest energy con…