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View article: Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia
Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia Open
[This corrects the article DOI: 10.3389/fpubh.2025.1594872.].
View article: Precision Genomics: A Reality Having Universal Impact in a New Era of Psychiatry – Lessons Learned, Past and Present
Precision Genomics: A Reality Having Universal Impact in a New Era of Psychiatry – Lessons Learned, Past and Present Open
Addiction neuroscience explores the complex interplay between genetic, neurobiological, environmental, and socio-spiritual factors underlying substance and behavioral addictions. Over the past three decades, research in this domain has ide…
View article: GWAS meta-meta-analysis and related analyses revealed a shared genetic background between ADHD and narcolepsy
GWAS meta-meta-analysis and related analyses revealed a shared genetic background between ADHD and narcolepsy Open
We previously theorized that Attention-Deficit Hyperactivity Disorder (ADHD) may increase susceptibility to narcolepsy and hypersomnia, potentially sharing genomic and pathophysiological features with addictive behaviours linked to Reward …
View article: Addiction Risk Polymorphisms Links Autism Spectrum Disorder with Reward Deficiency Syndrome: Insights from GWAS and Pharmacogenomic Meta Analyses
Addiction Risk Polymorphisms Links Autism Spectrum Disorder with Reward Deficiency Syndrome: Insights from GWAS and Pharmacogenomic Meta Analyses Open
Autism Spectrum Disorder (ASD) is a complex syndrome with a plethora of clinical manifestations. Although such variability may be attributable to diverse genetic and epigenetic factors, mesolimbic dopaminergic reward pathways are consisten…
View article: Pre-addiction phenotype is associated with dopaminergic dysfunction: Evidence from 88.8 million genome-wide association study-based samples
Pre-addiction phenotype is associated with dopaminergic dysfunction: Evidence from 88.8 million genome-wide association study-based samples Open
The convergence of neurogenetics, epigenetics, and functional neuroimaging presented in this article marks a critical inflection point in our understanding and management of reward deficiency syndrome (RDS) and its behavioral expressions a…
View article: Exploring dopamine as the master regulator of brain circuitry and mental health genome
Exploring dopamine as the master regulator of brain circuitry and mental health genome Open
Artificially increasing dopamine transmission is the common mechanism by which substances with addictive potential lead to addiction. A key area of research in neurobiology is the role of dopamine. Significant advancements have been made i…
View article: Criterion validity of the genetic addiction risk severity (GARS) as a marker of reward deficiency in polydrug addiction: a multi-center study
Criterion validity of the genetic addiction risk severity (GARS) as a marker of reward deficiency in polydrug addiction: a multi-center study Open
Aim : This study evaluated the Genetic Addiction Risk Severity (GARS) panel, which assesses genetic predisposition to addictive disorders by examining eleven polymorphisms in ten genes associated with dopaminergic reward system functioning…
View article: Genetic and Regulatory Mechanisms of Comorbidity of Anxiety, Depression and ADHD: A GWAS Meta-Meta-Analysis Through the Lens of a System Biological and Pharmacogenomic Perspective in 18.5 M Subjects
Genetic and Regulatory Mechanisms of Comorbidity of Anxiety, Depression and ADHD: A GWAS Meta-Meta-Analysis Through the Lens of a System Biological and Pharmacogenomic Perspective in 18.5 M Subjects Open
Background: In the United States, approximately 1 in 5 children experience comorbidities with mental illness, including depression and anxiety, which lead to poor general health outcomes. Adolescents with substance use disorders exhibit hi…
View article: Self Identity through the Lens of Awareness Integration Theory: Encouraging Novel Empirical Research to Uncover Molecular Neurobiological Correlates
Self Identity through the Lens of Awareness Integration Theory: Encouraging Novel Empirical Research to Uncover Molecular Neurobiological Correlates Open
This perspective paper addresses the multifaceted inner mechanism of self-awareness and self- identity developmental milestones as vital pathways to achieving evolutionary survival techniques, life satisfaction, and optimized psychopatholo…
View article: Enhancing Mental Health Support: Integrating Artificial Intelligence Powered Mobile Apps and Chatbots for Psychoeducation and Skill-Building
Enhancing Mental Health Support: Integrating Artificial Intelligence Powered Mobile Apps and Chatbots for Psychoeducation and Skill-Building Open
The advancement of digital mental health technologies offers transformative possibilities for increasing access to psychological support while presenting unique challenges in engagement and efficacy. This paper explores the integration of …
View article: Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy
Solving the Global Opioid Crisis: Incorporating Genetic Addiction Risk Assessment with Personalized Dopaminergic Homeostatic Therapy and Awareness Integration Therapy Open
We advocate reevaluating the "standard of care" and shifting towards inducing dopamine homeostasis by manipulating key neurotransmitter systems within the brain's reward cascade. We propose a paradigm shift towards a novel "standard of car…
View article: Addressing cortex dysregulation in youth through brain health check coaching and prophylactic brain development
Addressing cortex dysregulation in youth through brain health check coaching and prophylactic brain development Open
The Carter Center has estimated that the addiction crisis in the United States (US), if continues to worsen at the same rate, may cost the country approximately 16 trillion dollars by 2030. In recent years, the well-being of youth has been…
View article: The application of Awareness Integration Theory, a trauma-informed care modality: A systematic review
The application of Awareness Integration Theory, a trauma-informed care modality: A systematic review Open
Individuals impacted by trauma often have difficulty making sense of past traumatic events, memories, thoughts, feelings, and physical responses.Awareness Integration Theory (AIT) offers a trauma-informed care model by integrating emotiona…
View article: Awareness Integration Theory: An evidence-based multi-modality approach workshop
Awareness Integration Theory: An evidence-based multi-modality approach workshop Open
Awareness Integration Theory (AIT) is an evidence-based psychotherapy and psyche-education approach combining ideas from cognitive, emotional, behavioral, and body-mind theories.AIT promotes self-awareness, increases self-esteem, releases …
View article: Awareness integration theory A Psychological and genetic path to self-directed Neuroplasticity
Awareness integration theory A Psychological and genetic path to self-directed Neuroplasticity Open
The self-awareness technique is instrumental in increasing the efficacy of the brain's innate ability to adapt to change via neuroplasticity and self-directing clarity while improving neuro-network paths. The human brain is plastic and cap…
View article: Addictive Behavior and Evolutionary Adaptation: Mitigated through Genetic Addiction Risk Severity Early Identification and Awareness Integration Theory
Addictive Behavior and Evolutionary Adaptation: Mitigated through Genetic Addiction Risk Severity Early Identification and Awareness Integration Theory Open
Objectives: Humans, with their unique genetic profile, exhibit a greater propensity to develop and maintain addiction compared to other animals. This paper offers a detailed examination of addiction, co-occurring traits, and psychologic di…
View article: The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies
The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies Open
Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment app…
View article: Are We Getting High Cause the Thrill is Gone?
Are We Getting High Cause the Thrill is Gone? Open
In the USA alone, opioid use disorder (OUD) affects approximately 27 million people. While the number of prescriptions may be declining due to increased CDC guidance and prescriber education, fatalities due to fentanyl-laced street heroin …
View article: Neurogenetics and Epigenetics of Loneliness
Neurogenetics and Epigenetics of Loneliness Open
Abdalla Bowirrat,1 Igor Elman,2 Catherine A Dennen,3 Marjorie C Gondré-Lewis,4 Jean Lud Cadet,5 Jag Khalsa,6 David Baron,7 Diwanshu Soni,8 Mark S Gold,9 Thomas J McLaughlin,10 Debasis Bagchi,11 Eric R Braverman,12 Mauro Ceccanti,13 Panayo…
View article: Evidence for the <i>DRD2</i> Gene as a Determinant of Reward Deficiency Syndrome (RDS).
Evidence for the <i>DRD2</i> Gene as a Determinant of Reward Deficiency Syndrome (RDS). Open
Since 1990, published addiction psychiatry articles have exceeded 11,495. Several from Blum et al. showed the clinical relevance of the Genetic Addiction Risk Severity (GARS) test in identifying risk for reward deficiency behaviors in coho…
View article: Beyond Mor: Can Induction of Dopamine Homeostasis Along with Electrotherapy Attenuate the Opioid Crisis?
Beyond Mor: Can Induction of Dopamine Homeostasis Along with Electrotherapy Attenuate the Opioid Crisis? Open
One important area for consideration especially in terms of combating the ongoing never ending opioid crisis, relates to novel newer assessments for all addictive behaviors both substance and non-substance behaviors (RDS). It is very impor…
View article: Futuristic Thinking about Engineering "Geneospirituality" to Help Prevent Relapse of Reward Deficiency Syndrome (RDS) Behaviors.
Futuristic Thinking about Engineering "Geneospirituality" to Help Prevent Relapse of Reward Deficiency Syndrome (RDS) Behaviors. Open
It is with a saddened heart that we are dedicating this article to the loving memory of our dear departed friend and associate B. William Downs. Bill was well known in the nutritional space worldwide for his major contributions to the heal…
View article: Invited Expert Opinion- Bio-informatic and Limitation Di-rectives to Help Adopt Ge-netic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Re-quired Analytic Evidence to Induce Dopamine Homeo-statsis
Invited Expert Opinion- Bio-informatic and Limitation Di-rectives to Help Adopt Ge-netic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Re-quired Analytic Evidence to Induce Dopamine Homeo-statsis Open
Addiction, albeit some disbelievers like Mark Lewis [1], is a chronic, relapsing brain disease, resulting in unwanted loss of control over both substance and non- substance behavioral addictions leading to serious adverse consequences [2].…