Fook Tim Chew
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View article: Examining the diagnostic validity of the ISAAC asthma questionnaire among participants from Singapore and Malaysia
Examining the diagnostic validity of the ISAAC asthma questionnaire among participants from Singapore and Malaysia Open
Background: Asthma is a chronic respiratory condition affecting 3,340 cases per 100,000 individuals globally. The significant global health burden of asthma necessitates the development and use of valid diagnostic tools for epidemiological…
View article: Dietary interventions in skin ageing: a systematic review and meta-analysis
Dietary interventions in skin ageing: a systematic review and meta-analysis Open
Background Nutrition is a modifiable factor in skin ageing, but its effects remain inconsistently quantified. This meta-analysis assessed human studies from the Web of Science on dietary intake and skin ageing, using pooled standardised me…
View article: 130036 Y-split lateral rectus recession for bilateral exotropic duane retraction syndrome with severe downshoot: a case report
130036 Y-split lateral rectus recession for bilateral exotropic duane retraction syndrome with severe downshoot: a case report Open
View article: A Detailed Characterization of Asthma Manifestations and Their Associations with Dietary Intakes in a Singapore Cohort of Young Chinese Adults: A Cross-Sectional Study
A Detailed Characterization of Asthma Manifestations and Their Associations with Dietary Intakes in a Singapore Cohort of Young Chinese Adults: A Cross-Sectional Study Open
While certain plant-based foods and probiotic drinks were associated with reduced odds of AA and its phenotypes, these findings should be interpreted with caution given the cross-sectional design. Longitudinal or interventional studies are…
View article: Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population
Characterization of a major house dust mite allergen Der p 22 among Malaysian adult population Open
View article: Metabolomics of leafy vegetables: A systematic review of bioactive effects and factors influencing metabolic variation
Metabolomics of leafy vegetables: A systematic review of bioactive effects and factors influencing metabolic variation Open
View article: Genomic analyses of arugula (Eruca sativa) accessions reveal domestication history and breeding insights
Genomic analyses of arugula (Eruca sativa) accessions reveal domestication history and breeding insights Open
Eruca sativa , or arugula, a leafy vegetable from the Mediterranean region, is gaining popularity worldwide. However, its domestication history and genetic diversity remain poorly understood. This study investigates the genetic background …
View article: Phenotypic evaluation of worldwide germplasm of arugula (Eruca sativa Mill.) and identification of underlying latent factors contributing to phenotypic variation under indoor farming conditions
Phenotypic evaluation of worldwide germplasm of arugula (Eruca sativa Mill.) and identification of underlying latent factors contributing to phenotypic variation under indoor farming conditions Open
Eruca sativa (arugula) is often consumed fresh in regions where raw salads are a dietary staple. Studies investigating the phenotypic diversity of E. sativa have been reported in the past differentiating them by gene pools according to geo…
View article: The Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study: An Updated and Detailed Analysis of Acne Vulgaris Severity, Scarring, and Phenotypes and Their Associated Risk Factors among Young Chinese Adults
The Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study: An Updated and Detailed Analysis of Acne Vulgaris Severity, Scarring, and Phenotypes and Their Associated Risk Factors among Young Chinese Adults Open
Introduction: Despite the high prevalence of acne vulgaris and its impact on affected individuals, few studies have provided a detailed characterization of acne phenotypes and their associated risk factors. This study aimed to comprehensiv…
View article: Evaluating the Associations between Dietary Vitamin Intake and Atopic Dermatitis: A Regional Cross-Sequential Study among Singapore and Malaysia Young Chinese Adults
Evaluating the Associations between Dietary Vitamin Intake and Atopic Dermatitis: A Regional Cross-Sequential Study among Singapore and Malaysia Young Chinese Adults Open
This study demonstrates that naturally derived vitamins, estimated from whole foods in the diets of young Chinese adults from Singapore and Malaysia, are associated with atopic dermatitis (AD). Higher intake of vitamins E, K1, C, B2, and D…
View article: Exploratory analyses of frequent high-fat food intake in diets and its association with increased odds of atopic dermatitis in Singapore and Malaysia Young Chinese adults
Exploratory analyses of frequent high-fat food intake in diets and its association with increased odds of atopic dermatitis in Singapore and Malaysia Young Chinese adults Open
High-fat food intake is associated with atopic dermatitis (AD), but the role of habitual dietary habits related to the frequency of high-fat food intake remains unclear. To address this, we developed a frequency-based dietary index, Diet Q…
View article: TXK Functional Variants Contribute to Asthma by Regulating Th1 and Th17 Cytokine Pathways
TXK Functional Variants Contribute to Asthma by Regulating Th1 and Th17 Cytokine Pathways Open
Introduction: TXK regulates IFN-γ expression and T-helper (Th)1 cell-mediated inflammation that underlies the development of neutrophilic asthma; however, its implication in asthma remains uncertain. This study aimed to functionally charac…
View article: Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes
Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes Open
View article: A broad assessment of forty-one skin phenotypes reveals complex dimensions of skin ageing
A broad assessment of forty-one skin phenotypes reveals complex dimensions of skin ageing Open
View article: Associations Between Self‐Reported Dietary Intake and Atopic Dermatitis Risk in Young Adults From Singapore and Malaysia
Associations Between Self‐Reported Dietary Intake and Atopic Dermatitis Risk in Young Adults From Singapore and Malaysia Open
View article: Frequent intake of high fiber and probiotic diets lowers risks associated with atopic dermatitis and house dust mite allergy: a cross-sequential study of young Chinese adults from Singapore and Malaysia
Frequent intake of high fiber and probiotic diets lowers risks associated with atopic dermatitis and house dust mite allergy: a cross-sequential study of young Chinese adults from Singapore and Malaysia Open
A high-fiber diet is associated with AD and HDM allergy. Moderate-to-high fiber intake, particularly in conjunction with probiotics, may further mitigate AD risks.
View article: Comparisons between Caucasian-validated and Chinese-validated photo-numeric scales for assessing facial wrinkles
Comparisons between Caucasian-validated and Chinese-validated photo-numeric scales for assessing facial wrinkles Open
View article: Residential exposure to<i>Aspergillus</i>spp<i>.</i>is associated with exacerbations in COPD
Residential exposure to<i>Aspergillus</i>spp<i>.</i>is associated with exacerbations in COPD Open
Background Sensitisation to Aspergillus fumigatus is linked to worse outcomes in patients with COPD; however, its prevalence and clinical implications in domestic (residential) settings remains unknown. Methods Individuals with COPD (n=43)…
View article: Genomic selection for crop improvement in fruits and vegetables: a systematic scoping review
Genomic selection for crop improvement in fruits and vegetables: a systematic scoping review Open
View article: Functional Polymorphisms Regulate <i>FOXO1</i> Transcript Expression and Contribute to the Risk and Symptom Severity of HDM-Induced Allergic Rhinitis
Functional Polymorphisms Regulate <i>FOXO1</i> Transcript Expression and Contribute to the Risk and Symptom Severity of HDM-Induced Allergic Rhinitis Open
Introduction: FOXO1 plays an important role in regulating immune processes that contribute to allergic inflammation; however, genetic variants influencing FOXO1 expression in AR pathogenesis remains unclear. Thi…
View article: The burden of allergic rhinitis is undermanaged in a large proportion of Chinese young adults from Singapore
The burden of allergic rhinitis is undermanaged in a large proportion of Chinese young adults from Singapore Open
There was a significant difference in TNSS of the AR phenotypes, and among phenotypes with a higher mTNSS, a large proportion remained untreated, undiagnosed, or both. The evidence indicates an existing burden of AR among Chinese young adu…
View article: Association of Frequent Intake of Trans Fatty Acids and Saturated Fatty Acids in Diets with Increased Susceptibility of Atopic Dermatitis Exacerbation in Young Chinese Adults: A Cross-Sectional Study in Singapore/Malaysia
Association of Frequent Intake of Trans Fatty Acids and Saturated Fatty Acids in Diets with Increased Susceptibility of Atopic Dermatitis Exacerbation in Young Chinese Adults: A Cross-Sectional Study in Singapore/Malaysia Open
Background & Objective Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of f…
View article: The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis
The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis Open
Introduction: Allergic diseases remain of concern due to their increasing prevalence worldwide. Intrinsic and environmental risk factors have been implicated in the pathogenesis of allergic disease. Among the possible risk factors, migrati…
View article: Comparisons between wrinkles and photo-ageing detected and self-reported by the participant or identified by trained assessors reveal insights from Chinese individuals in the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES) cohort
Comparisons between wrinkles and photo-ageing detected and self-reported by the participant or identified by trained assessors reveal insights from Chinese individuals in the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES) cohort Open
Background Changes develop on the facial skin as a person ages. Other than chronological time, it has been discovered that gender, ethnicity, air pollution, smoking, nutrition, and sun exposure are notable risk factors that influence the d…
View article: Comparisons between Caucasian‐validated photo‐numeric scales and Korean‐validated photo‐numeric scales for photo‐ageing. Insights from the Singapore/Malaysia cross‐sectional genetics epidemiology study (SMCGES) cohort
Comparisons between Caucasian‐validated photo‐numeric scales and Korean‐validated photo‐numeric scales for photo‐ageing. Insights from the Singapore/Malaysia cross‐sectional genetics epidemiology study (SMCGES) cohort Open
Background Photo‐ageing is a form of skin ageing which affects the entire face. A photo‐aged skin has a diverse variety of wrinkles and dyspigmentation all over the face. Here, we discuss photo‐ageing on the Chinese skin evaluated using a …
View article: Comparisons between eyebags, droopy eyelids, and eyebrow positioning identified by photo‐numeric scales or identified by written descriptive scales: Insights from the Singapore/Malaysia cross‐sectional genetics epidemiology study (SMCGES) cohort
Comparisons between eyebags, droopy eyelids, and eyebrow positioning identified by photo‐numeric scales or identified by written descriptive scales: Insights from the Singapore/Malaysia cross‐sectional genetics epidemiology study (SMCGES) cohort Open
Background We evaluate skin sagging phenotypes (eyebags, droopy eyelids, low eyebrow positioning) using written descriptive scales and photo‐numeric scales. We also study how anti‐ageing interventions and digital screen time influence skin…
View article: Sleep and allergic diseases among young Chinese adults from the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) cohort
Sleep and allergic diseases among young Chinese adults from the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) cohort Open
View article: Atopic dermatitis-associated genetic variants regulate LOC100294145 expression implicating interleukin-27 production and type 1 interferon signaling
Atopic dermatitis-associated genetic variants regulate LOC100294145 expression implicating interleukin-27 production and type 1 interferon signaling Open
View article: Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis
Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis Open
Background: This scoping review aims to critically assess gaps in the current literature on atopic dermatitis (AD) by evaluating the overall effectiveness of dietary interventions. Through a comprehensive analysis that follow…
View article: Sensitization to oil palm pollen associates with risks and severity of allergic diseases
Sensitization to oil palm pollen associates with risks and severity of allergic diseases Open