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View article: <i>Helicobacter pylori</i>: Detection of <i>dupA, iceA and cagE</i> genes in Ghanaian patients with dyspepsia
<i>Helicobacter pylori</i>: Detection of <i>dupA, iceA and cagE</i> genes in Ghanaian patients with dyspepsia Open
Helicobacter pylori infection in Ghana is associated with various gastroduodenal pathologies, and its virulence is linked with several genes, some of which are connected to serious clinical disorders. However, limited information exists re…
View article: A survey of the cytotoxicity of some medicinal plant extracts in Ghana against breast and prostate cancer cells
A survey of the cytotoxicity of some medicinal plant extracts in Ghana against breast and prostate cancer cells Open
Cancer remains a global health challenge, with breast and prostate cancers being significant contributory factors to morbidity and mortality. Current treatments are limited by high costs, resistance, and adverse effects hence prompting the…
View article: Prevalence of tuberculosis in selected prisons in Ghana: a baseline study using the CapiliaTM TB-Neo assay
Prevalence of tuberculosis in selected prisons in Ghana: a baseline study using the CapiliaTM TB-Neo assay Open
There is very little information on the nature and extent of Tuberculosis in institutionalised sections of the Ghanaian population such as the prisons is disturbing, and therefore any attempt in rapidly and accurately diagnosing the diseas…
View article: Viral kinetics among persons living with HIV (PLWH) on Dolutegravir-based antiretroviral Regimen: A retrospective and prospective analysis from selected HIV clinics in Ghana
Viral kinetics among persons living with HIV (PLWH) on Dolutegravir-based antiretroviral Regimen: A retrospective and prospective analysis from selected HIV clinics in Ghana Open
Background Dolutegravir (DTG)-based antiretroviral therapy has demonstrated superior efficacy, tolerability, and durability when compared to other HIV treatment regimens. However, monitoring viral kinetics is critical for determining treat…
View article: Macrophage immunometabolism dysregulation and inflammatory disorders
Macrophage immunometabolism dysregulation and inflammatory disorders Open
Macrophages are innate immune cells which are involved in triggering inflammation. Growing evidence shows that, macrophages respond to intracellular and extracellular cues which makes them adopt either anti-inflammatory or pro-inflammatory…
View article: Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women
Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women Open
Background Blood lipids are implicated in the development of breast cancer (BC), though the genetic connection remains unclear, particularly in African populations. Observational studies on this topic are limited by confounding factors and…
View article: Current advances in bispecific T cell–engaging therapies
Current advances in bispecific T cell–engaging therapies Open
The emergence of bispecific antibodies has transformed cancer immunotherapy, highlighting increased clinical efficacy, especially in hematological malignancies. These innovative molecules uniquely target two distinct tumor antigens or sepa…
View article: Mutational analysis of antibiotic resistance genes in Helicobacter pylori from Ghanaian dyspepsia patients: Implications for treatment strategies
Mutational analysis of antibiotic resistance genes in Helicobacter pylori from Ghanaian dyspepsia patients: Implications for treatment strategies Open
Background: Antibiotic resistance jeopardizes the effectiveness of conventional treatment regimens for Helicobacter pylori infections, and this remains a major global health concern. H. pylori genes mutations negatively affect actions of m…
View article: Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women
Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women Open
Backgrounds Blood lipids are associated with breast cancer. An increasing number of reports have attempted to explore the genetic connection between blood lipids and the risk of developing breast cancer. However, observational studies can …
View article: Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women
Associations Between Lipid Traits and Breast Cancer Risk: A Mendelian Randomization Study in African Women Open
Blood lipids are associated with breast cancer. An increasing number of reports have attempted to explore the genetic connection between blood lipids and the risk of developing breast cancer. However, observational studies can be affected …
View article: Initial assessment of Id protein antagonist (aHLH) shows anti-proliferative activity on HEK293T, LS174T and HCT116 cells
Initial assessment of Id protein antagonist (aHLH) shows anti-proliferative activity on HEK293T, LS174T and HCT116 cells Open
Id proteins (1–4) which are dominant-negative antagonists of the basic helix-loop-helix (bHLH) family of transcription factors function in a variety of cellular processes. They bind to the ubiquitously expressed ‘E box’ protein of the clas…
View article: Assessment of pig farmer’s knowledge on influenza a virus, and adoption of biosecurity measures in areas with previous outbreak of avian influenza in the Greater Accra Region of Ghana
Assessment of pig farmer’s knowledge on influenza a virus, and adoption of biosecurity measures in areas with previous outbreak of avian influenza in the Greater Accra Region of Ghana Open
Influenza A virus continues to have a devastating effect on livestock, especially in Africa typified by lack of standardized prevention protocols and low level of compliance to biosecurity. Pig handlers are more vulnerable since pigs serve…
View article: Chlamydia trachomatis Stimulation Enhances HIV-1 Susceptibility through the Modulation of a Member of the Macrophage Inflammatory Proteins
Chlamydia trachomatis Stimulation Enhances HIV-1 Susceptibility through the Modulation of a Member of the Macrophage Inflammatory Proteins Open
Sexually transmitted infections such as Chlamydia trachomatis can enhance HIV-1 infection. However, the molecular mechanisms modulating the enhancement of HIV-1 infectivity and replication during HIV-1/sexually transmitted infections coinf…
View article: Additional file 4 of Host cell response and distinct gene expression profiles at different stages of Chlamydia trachomatis infection reveals stage-specific biomarkers of infection
Additional file 4 of Host cell response and distinct gene expression profiles at different stages of Chlamydia trachomatis infection reveals stage-specific biomarkers of infection Open
Additional file 4: Supplementary Table 1 List of Primers used in this study.
View article: Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors
Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors Open
Introduction. Head and neck tumors (HNT) are tumors that normally occur at the head and neck region of the body. Epidermal growth factor receptor (EGFR) has been found to be highly expressed in breast and other tumors; therefore, there is …
View article: <i>Helicobacter pylori</i>Infection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation
<i>Helicobacter pylori</i>Infection, Virulence Genes’ Distribution and Accompanying Clinical Outcomes: The West Africa Situation Open
Data on Helicobacter pylori ( H. pylori ) infection and virulence factors in countries across West Africa are scattered. This systematic review seeks to present an update on the status of H. pylori infection focusing on prevalence rate, di…
View article: Over-expression of Id2 and Id3 Proteins Regulates Growth and Survival of Human Colon Carcinoma (HCT116) Cells
Over-expression of Id2 and Id3 Proteins Regulates Growth and Survival of Human Colon Carcinoma (HCT116) Cells Open
Inhibitor of differentiation (Id) proteins are members of the Helix-Loop-Helix (HLH) group of transcription factors.These proteins uniquely have no DNA-binding domain and they play vital roles in cell growth, differentiation, senescence, a…
View article: Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana
Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana Open
Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the pathogenesis of NPC. H…
View article: Down-regulation of Id1 and Id3 genes affects growth and survival of Human Umbilical Vein Endothelial Cells (HUVECs)
Down-regulation of Id1 and Id3 genes affects growth and survival of Human Umbilical Vein Endothelial Cells (HUVECs) Open
Inhibitors of DNA (Id) proteins have been implicated in cell growth, cell cycle control, apoptosis and angiogenesis.Studies reveal that Id1 and Id3 may be required for angiogenesis in adult tissues.This work aimed at investigating the cons…