Explanipedia

OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome Open

Alessandro Prete, Lida Adbi, Joshua Bain, Fozia Shaheen, Onnicha Suntornlohanakul , et al. · 2025

Disclosure: A. Prete: HRA Pharmaceuticals, Lundbeck, Diurnal. L. Adbi: None. J.T. Bain: None. F. Shaheen: None. O. Suntornlohanakul: None. E. Deflorenne: None. A. Blanchard: None. M. Nestola: None. C. Pamporaki: None. I. Tizianel: None. E.…

Hepatic metabolism of 11-oxygenated androgens in humans: an integrated <i>in vivo</i> and <i>ex vivo</i> approach Open

Tara McDonnell, Amarah Anthony, George R. G. Clarke, Lina Schiffer, Angela E. Taylor , et al. · 2025

Objective Excess production of adrenal-derived 11-oxygenated androgens is observed in congenital adrenal hyperplasia, premature adrenarche, and polycystic ovary syndrome. 11-Ketotestosterone is equipotent to testosterone but does not decli…

Steroid Metabolome Profiling Identifies a Unique Androgen Hormone Signature Associated with Endometriosis Open

Ioannis Simitsidellis, Rebecca J. Ainslie, Angela Taylor, Lorna C Gilligan, Fozia Shaheen , et al. · 2025

Endometriosis is a chronic, hormone-dependent condition that affects 190 million women worldwide. There are no validated biomarkers for endometriosis and this delays diagnosis and treatment. We performed serum steroid metabolome profiling …

Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor Open

Elisabeth Ng, Yun-Ni Lee, Angela E. Taylor, Fozia Shaheen, Elena Azizan , et al. · 2025

Context Primary aldosteronism (PA) is commonly caused by somatic mutations of CACNA1D encoding Cav1.3, one of the four L-type calcium channels. The over-the-counter drug, cinnarizine, fits the Cav1.3 crystal structure pore domain. Objectiv…

Multidimensional Tetrametallic Sulfide (Nicus, Nimo3s4) and Cnt-Integrated Nanocomposites Electrodes for Enhanced Supercapacitor Performance Open

Nida Shahbaz, Ayesha Meraj, Rehana Sharif, Fozia Shaheen, Anam Qaisar , et al. · 2025

Validation of a Method for Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography Tandem Mass Spectrometry Open

Joshua Bain, Fozia Shaheen, Alessandro Prete, Lorna C Gilligan, Angela E. Taylor · 2025

The Influence of Zirconia Opaquer and Thickness of Monolithic Zirconia on the Final Shade Open

Fozia Shaheen, Björn Gjelvold · 2024

Statement of problem. Monolithic zirconia can be influenced by the underlying titanium base which alters the restoration shade and creates unsatisfactory optical results. Purpose. The purpose of this in vitro study is to find out the influ…

Impaired 11β-Hydroxysteroid Dehydrogenase Type 2 Activity in Kidney Disease Disrupts 11-Oxygenated Androgen Biosynthesis Open

Maria Tomkins, Tara McDonnell, Leanne Cussen, Michael Sagmeister, Imken Oestlund , et al. · 2024

Context 11-Oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) in 11-oxygenated androgen biosynthesi…

Optimizing energy storage: Carbon implantation in NiO matrix unveils C–NiO's hybrid capacitive and battery-like behavior with enhanced electrochemical performance Open

Muhammad Ahsan Shafique, Ghulam Farid, Fozia Shaheen, Zeeshan Zaheer, G. Murtaza , et al. · 2024

Doping is a common strategy employed to enhance material properties. Numerous researchers have introduced carbon into the nickel oxide (NiO) matrix through various methods to improve the electrochemical performance for energy storage appli…

Bridging the gap: an in-depth comparison of CVT-grown layered transition metal dichalcogenides for supercapacitor applications Open

Muhammad Habib, Zahir Muhammad, Yasir A. Haleem, Sajid Farooq, Raziq Nawaz , et al. · 2023

This study provides insights into the intrinsic behaviour of the TMDC synthesized via CVT technique as electrode materials in the field of electrochemical energy storage devices.

OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles. Open

Thaís Rocha, Eka Melson, Roland J. Veen, Lida Abdi, Tara McDonnell , et al. · 2023

Disclosure: T.P. Rocha: None. E. Melson: None. R.J. Veen: None. L. Abdi: None. T. McDonnell: None. V. Tandl: None. J. Hawley: None. L. Wittemans: None. A. Anthony: None. L. Gilligan: None. F. Shaheen: None. P. Kempegowda: None. C.D. Gillet…

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy Open

Rosemary Dineen, Julie Martin‐Grace, Khalid Mohamed Ahmed, Angela E. Taylor, Fozia Shaheen , et al. · 2023

Background Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We…

The ultra-acute steroid response to traumatic injury: a cohort study Open

Conor Bentley, Jon Hazeldine, Laura Bravo, Angela E. Taylor, Lorna C Gilligan , et al. · 2023

Objective Trauma-induced steroid changes have been studied post-hospital admission, resulting in a lack of understanding of the speed and extent of the immediate endocrine response to injury. The Golden Hour study was designed to capture t…

Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation Open

Lina Schiffer, Punith Kempegowda, Alice Sitch, Jo Adaway, Fozia Shaheen , et al. · 2023

Objective 11-oxygenated androgens significantly contribute to the circulating androgen pool. Understanding the physiological variation of 11-oxygenated androgens and their determinants is essential for clinical interpretation, for example,…

Architecture of Hybrid Electrode by the Composition of Comoo4 /Rgo/Pani for Asymmetric Supercapacitors Open

Hafiz Muhammad Fahad, Riaz Ahmad, Fozia Shaheen, Muneerah Alomar, Muhammad Hammad Aziz · 2023

Biogenic-Ecofriendly Synthesized Sno2/Cuo/Feo/Pvp/Rgo Nanocomposite for Enhancing Energy Density Performance of Hybrid Supercapacitors Open

Umm e. Ruman, Muhammad Hammad Aziz, Hafiz Muhammad Fahad, Fozia Shaheen, Riaz Ahmad , et al. · 2023

A case of unilateral post-COVID-19 adrenal haemorrhage and follow-up during pregnancies Open

Alessandra Mangone, Quratulain Yousuf, Wiebke Arlt, Alessandro Prete, Fozia Shaheen , et al. · 2022

Summary The spectrum of endocrine-related complications of COVID-19 infection is expanding; one of the most concerning of which is adrenal haemorrhage due to the risk of catastrophic adrenal crisis. In this study, we present a case that hi…

Multi-steroid profiling by UHPLC-MS/MS with post-column infusion of ammonium fluoride Open

Lina Schiffer, Fozia Shaheen, Lorna C Gilligan, Karl‐Heinz Storbeck, James Hawley , et al. · 2022

Multi-steroid profiling by uPLC-MS/MS with post-column infusion of ammonium fluoride Open

Lina Schiffer, Fozia Shaheen, Lorna C Gilligan, Karl‐Heinz Storbeck, James Hawley , et al. · 2022

Background Multi-steroid profiling is a powerful analytical tool that simultaneously quantifies steroids from different biosynthetic pathways. Here we present an ultra-high performance liquid chromatography-tandem mass spectrometry (uPLC-M…

Green synthesis of RGO-ZnO mediated Ocimum basilicum leaves extract nanocomposite for antioxidant, antibacterial, antidiabetic and photocatalytic activity Open

Abdul Malik, Sadia Sharif, Fozia Shaheen, Mansoor Khalid, Yasir Iqbal , et al. · 2022

Green chemistry of nanomaterials from synthesis to diverse biomedical applications is a discussion of town in the current scientific scenario. In this work, Ocimum basilicum leaves extract was utilized as the reducing agent in the synthesi…

Comparative Analysis of the Cvt Grown Layered Transition Metal Dichalcogenides for Supercapacitor Application Open

Muhammad Ahsanul Habib, Zahir Muhammad, Yasir A. Haleem, Adnan Khalil, Sami Ullah , et al. · 2022

The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series Open

Min Sun, Jonathan Wolf Mueller, Lorna C Gilligan, Angela E. Taylor, Fozia Shaheen , et al. · 2021

Context 17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by mutations in the CYP17A1 gene is a rare form of congenital adrenal hyperplasia typically characterised by cortisol deficiency, mineralocorticoid excess and sex steroid defici…

A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT Open

Conor Bentley, Claire Potter, Kamal Makram Yakoub, Kristian Brock, Victoria Homer , et al. · 2021

Introduction The improvements in short-term outcome after severe trauma achieved through early resuscitation and acute care can be offset over the following weeks by an acute systemic inflammatory response with immuneparesis leading to inf…

A Prospective Cross-Over Study of Tissue Glucocorticoid Metabolism in Patients With Adrenal Insufficiency: The Effects of Dual-Release Hydrocortisone Therapy Open

Rosemary Dineen, Julie Martin‐Grace, Khalid Mohamed Ahmed, Angela E. Taylor, Fozia Shaheen , et al. · 2021

Background: Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). W…

Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure Open

Olivia Grech, Andrew Clouter, James Mitchell, Zerin Alimajstorovic, Ryan Ottridge , et al. · 2021

Cognitive impairments have been reported in idiopathic intracranial hypertension; however, evidence supporting these deficits is scarce and contributing factors have not been defined. Using a case-control prospective study, we identified m…

Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study Open

Mark Foster, Angela E. Taylor, Neil Hill, Conor Bentley, Jonathan Bishop , et al. · 2020

Context Survival rates after severe injury are improving, but complication rates and outcomes are variable. Objective This cohort study addressed the lack of longitudinal data on the steroid response to major trauma and during recovery. De…

Synthesis of NiO nanoparticles and their evaluation for photodynamic therapy against HeLa cancer cells Open

Mohamad S. AlSalhi, Muhammad Hammad Aziz, M. Atif, Mahvish Fatima, Fozia Shaheen , et al. · 2019

The worldwide increase in malignancy rates has caused an increase of research interest for compelling and safe materials used for cancer treatment. A standout amongst the most pervasive types of treatment for malignant growth is photodynam…

Mapping the steroid response to major trauma from injury to recovery: a prospective cohort study Open

Mark Foster, Angela E. Taylor, Neil Hill, Conor Bentley, Jonathan Bishop , et al. · 2019

Context Survival rates after severe injury are improving, but complication rates and outcomes are variable. Objective This cohort study addressed the lack of longitudinal data on the steroid response to major trauma and during recovery. De…

Structural, surface morphology, dielectric and magnetic properties of holmium doped BiFeO3 thin films prepared by pulsed laser deposition Open

Sadia Sharif, G. Murtaza, T. Meydan, Paul Williams, Jerome A. Cuenca , et al. · 2018

In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping Open

Fozia Shaheen, Muhammad Hammad Aziz, Mahvish Fatima, M. Ajmal Khan, Faisal Ahmed , et al. · 2018

Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graph…

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