Fradique Moreira
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View article: Insights into retention and safety/tolerability of apomorphine sublingual film in patients with Parkinson’s disease and OFF episodes: post hoc analyses of a phase III, open-label study
Insights into retention and safety/tolerability of apomorphine sublingual film in patients with Parkinson’s disease and OFF episodes: post hoc analyses of a phase III, open-label study Open
Background: Managing OFF episodes in patients with Parkinson’s disease becomes increasingly challenging over time, making it critical to tailor treatment to each patient’s needs and characteristics for effective care. Objectives: Study CTH…
View article: Atypical Parkinsonism with Eye-of-the-Tiger Sign
Atypical Parkinsonism with Eye-of-the-Tiger Sign Open
View article: Atypical Parkinsonism Presenting with Isolated Gaze Palsy
Atypical Parkinsonism Presenting with Isolated Gaze Palsy Open
View article: Peri-Lead Edema After Deep Brain Stimulation Surgery for Parkinson Disease: A Management Challenge
Peri-Lead Edema After Deep Brain Stimulation Surgery for Parkinson Disease: A Management Challenge Open
Deep brain stimulation (DBS) is a well-established surgical treatment for Parkinson’s disease. Peri-lead edema (PLE) is a poorly understood complication of DBS. We hereby report three cases of unilateral PLE after bilateral subthalamic nuc…
View article: <i>PRKRAP1</i> Pseudogene Complicating the Diagnosis of Young‐Onset Dystonia Due to <i>PRKRA</i> Gene Disease‐Causing Variants (<scp>DYT‐</scp><i>PRKRA</i>)
<i>PRKRAP1</i> Pseudogene Complicating the Diagnosis of Young‐Onset Dystonia Due to <i>PRKRA</i> Gene Disease‐Causing Variants (<span>DYT‐</span><i>PRKRA</i>) Open
A genetic etiology of isolated dystonia is suspected if there is an early-onset dystonia or a positive family history. However, the current overall yield of a genetic etiological diagnosis remains below 30%.1 We present a case of a 13-year…
View article: Correction to the article “Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease”, Published on Acta Med Port 2021 Jan;34(1):6-11.
Correction to the article “Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease”, Published on Acta Med Port 2021 Jan;34(1):6-11. Open
On the title of Appendix 1, where it reads:“Appendix 1: Validated European Portuguese version of the “Non-Motor Symptoms Questionnaire”It should read:“Appendix 1: Validated European Portuguese version of the “Non-Motor Symptoms Questionnai…
View article: Automatic classification of idiopathic Parkinson’s disease and atypical Parkinsonian syndromes combining [<sup>11</sup>C]raclopride PET uptake and MRI grey matter morphometry
Automatic classification of idiopathic Parkinson’s disease and atypical Parkinsonian syndromes combining [<sup>11</sup>C]raclopride PET uptake and MRI grey matter morphometry Open
Objective. To explore the viability of developing a computer-aided diagnostic system for Parkinsonian syndromes using dynamic [ 11 C]raclopride positron emission tomography (PET) and T1-weighted magnetic resonance imaging (MRI) data. Appro…
View article: Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease
Translation, Adaptation and Validation of the European Portuguese Version of the NMS-Quest for Parkinson’s Disease Open
Introduction: Non-motor symptoms are underrecognized features of Parkinson’s disease that impair quality of life and increase mortality. In this study, we aim to translate, adapt and validate the European Portuguese version of the “Non-Mot…
View article: Freezing of gait and postural instability: the unpredictable response to levodopa in Parkinson’s disease
Freezing of gait and postural instability: the unpredictable response to levodopa in Parkinson’s disease Open
Freezing of gait (FOG) and postural instability are challenging motor symptoms that present a serious therapeutic dilemma in Parkinson’s disease. Appropriate distinction between FOG subtypes may be difficult during routine clinical visits,…
View article: Coreia Aguda Generalizada, Distonia e Calcificações Cerebrais: A Propósito de um Caso Clínico
Coreia Aguda Generalizada, Distonia e Calcificações Cerebrais: A Propósito de um Caso Clínico Open
A calcificação dos núcleos da base, ou síndrome de Fahr, pode ser secundária a variadas doenças, nomeadamente as que cursam com envolvimento da paratiróide. Distúrbios do movimento são achados clínicos comuns, mas a coreia é observada em m…
View article: Early-onset oromandibular-laryngeal dystonia and Charlot gait
Early-onset oromandibular-laryngeal dystonia and Charlot gait Open
A 28-year-old man had spasmodic dysphonia due to focal oromandibular-laryngeal dystonia from the age of 6, evolving rostrocaudally into a particular gait dystonia resembling Charlie Chaplin's Charlot gait (video 1). Recently he developed a…
View article: Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment
Impulsivity across reactive, proactive and cognitive domains in Parkinson's disease on dopaminergic medication: Evidence for multiple domain impairment Open
Impulse control disorders (ICD) may occur in Parkinson's disease (PD) although it remains to be understood if such deficits may occur even in the absence of a formal ICD diagnosis. Moreover, studies addressing simultaneously distinct neuro…
View article: Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study
Clinical rating scale for pantothenate kinase‐associated neurodegeneration: A pilot study Open
Background Pantothenate kinase‐associated neurodegeneration is a progressive neurological disorder occurring in both childhood and adulthood. The objective of this study was to design and pilot‐test a disease‐specific clinical rating scale…
View article: Subthalamic nucleus deep brain stimulation surgery in Parkinson’s disease – longitudinal behavioral and cognitive assessment
Subthalamic nucleus deep brain stimulation surgery in Parkinson’s disease – longitudinal behavioral and cognitive assessment Open
View article: Erratum
Erratum Open
View article: Mielite Extensa como Manifestação de Neuroborreliose
Mielite Extensa como Manifestação de Neuroborreliose Open
As manifestações neurológicas na doença de Lyme ocorrem em 3% - 12% dos doentes, sendo a forma de apresentação mais comum a meningorradiculite. Outros sintomas de envolvimento do sistema nervoso central, como encefalomielite ou mielite são…