Explanipedia

Glycemia and Gluconeogenesis With Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes Open

Katrina Dietsche, Sheela N. Magge, Sydney A Dixon, Faith Davis, Andrea Krenek , et al. · 2023

Objective Elevated rates of gluconeogenesis are an early pathogenic feature of youth-onset type 2 diabetes (Y-T2D), but targeted first-line therapies are suboptimal, especially in African American (AA) youth. We evaluated glucose-lowering …

Effects of Low-Calorie Sweetener Restriction on Glycemic Variability and Cardiometabolic Health in Children with Type 1 Diabetes: Findings of a Pilot and Feasibility Study Open

Allison C. Sylvetsky, Hailey Moore, Xinyu Zhu, Jasmine H. Kaidbey, Leyi Kang , et al. · 2023

Low-calorie sweeteners (LCS) are commonly consumed by children with type 1 diabetes (T1D), yet their role in cardiometabolic health is unclear. This study examined the feasibility, acceptability, and preliminary effects of 12 weeks of LCS …

Preferences for Health Care Professional Interactions Among Adolescents and Young Adults with Type 1 Diabetes Open

Christine H. Wang, Breana L. Bryant, Fran R. Cogen, Brynn E. Marks, Maureen Monaghan · 2023

P18-064-23 Effects of Low-Calorie Sweetened Beverage Restriction on Glycemic Variability in Youth With Type 1 Diabetes Open

Xinyu Zhu, Hailey Moore, Jasmine H. Kaidbey, Leyi Kang, Janae Kuttamperoor , et al. · 2023

First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children with New Onset Type 1 Diabetes Open

Marisa E. Hilliard, Carrie Tully, Maureen Monaghan, Tom Hildebrandt, Christine H. Wang , et al. · 2023

Objective: Despite the emotional challenges of parental adjustment to a child’s type 1 diabetes diagnosis and the unique complexities of early childhood, there are few programs designed to meet the needs of parents of young children at n…

Parent Perspectives of School/Daycare Experiences in Young Children Newly Diagnosed With Diabetes Open

Alexa Stern, Brenda Duran, Randi Streisand, Christine H. Wang, Carrie Tully , et al. · 2023

Objective A central part of family adjustment to a new diagnosis of type 1 diabetes (T1D) is integrating T1D management into the child’s school/daycare. This may be particularly challenging for young children who rely on adults for their d…

Positive Impact of the Bionic Pancreas on Diabetes Control in Youth 6–17 Years Old with Type 1 Diabetes: A Multicenter Randomized Trial Open

Laurel H. Messer, Bruce A. Buckingham, Fran R. Cogen, Mark Daniels, Gregory P. Forlenza , et al. · 2022

Objective: To evaluate the insulin-only configuration of the iLet^® bionic pancreas (BP) in youth 6-17 years old with type 1 diabetes (T1D). Research Design and Methods: In this multicenter, randomized…

Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes Open

Steven J. Russell, Roy W. Beck, Edward R. Damiano, Firas H. El-Khatib, Katrina J. Ruedy , et al. · 2022

In this 13-week, randomized trial involving adults and children with type 1 diabetes, use of a bionic pancreas was associated with a greater reduction than standard care in the glycated hemoglobin level. (Funded by the National Institute o…

Impacts of the COVID-19 Pandemic on Pediatric Type 1 Diabetes Management: A Qualitative Study Open

Kacey Ferguson, Hailey Moore, Jasmine H. Kaidbey, Shazmenna Khattak, Abbas Saeed , et al. · 2022

Purpose: The purpose of this study was to understand impacts of the coronavirus (COVID-19) pandemic on pediatric type 1 diabetes management. Methods: In-depth qualitative interviews were conducted with 15 parents of children (age 6-12 year…

First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children with New Onset Type 1 Diabetes Open

Marisa E. Hilliard, Carrie Tully, Maureen Monaghan, Tom Hildebrandt, Christine H. Wang , et al. · 2022

Objective: Despite the emotional challenges of parental adjustment to a child’s type 1 diabetes diagnosis and the unique complexities of early childhood, there are few programs designed to meet the needs of parents of young children at n…

First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children With New-Onset Type 1 Diabetes Open

Marisa E. Hilliard, Carrie Tully, Maureen Monaghan, Tom Hildebrandt, Christine H. Wang , et al. · 2022

OBJECTIVE Despite the emotional challenges of parental adjustment to a child’s type 1 diabetes diagnosis and the unique complexities of early childhood, there are few programs designed to meet the needs of parents of young children at new …

First STEPS: Primary Outcomes of a Randomized, Stepped-Care Behavioral Clinical Trial for Parents of Young Children with New Onset Type 1 Diabetes Open

Marisa E. Hilliard, Carrie Tully, Maureen Monaghan, Tom Hildebrandt, Christine H. Wang , et al. · 2022

Objective: Despite the emotional challenges of parental adjustment to a child’s type 1 diabetes diagnosis and the unique complexities of early childhood, there are few programs designed to meet the needs of parents of young children at n…

Promoting glycemic control in young children with type I diabetes: Results from a pilot intervention for parents. Open

Eleanor R. Mackey, Carrie Tully, Meredith Rose, Samantha Hamburger, Jichuan Wang , et al. · 2022

The TOTs program demonstrated preliminary feasibility and acceptability. Future research will examine components of treatment for evidence of efficacy and target the intervention to those most likely to benefit. (PsycInfo Database Record (…

Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes Open

R. Speakman J, Beck R.W, Damiano E.R, El-Khatib F.H, Ruedy K.J , et al. · 2022

BACKGROUND Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pa…

Rationale and design of DRINK-T1D: A randomized clinical trial of effects of low-calorie sweetener restriction in children with type 1 diabetes Open

Allison C. Sylvetsky, Hailey Moore, Jasmine H. Kaidbey, Sabrina Halberg, Fran R. Cogen , et al. · 2021

Metformin treatment and gastrointestinal symptoms in youth: Findings from a large tertiary care referral center Open

Abby G. Meyers, Jennifer Hudson, CELESTE K. CRAVALHO, SAMANTHA MATTA, ALFREDO VILLALOBOS-PEREZ , et al. · 2020

GI symptoms are common in youth with type 2 diabetes taking metformin XR and SR. Adjuncts to mitigate GI symptoms in youth on metformin therapy are needed to improve quality of life and medication adherence.

Author response for "Metformin Treatment and Gastrointestinal Symptoms in Youth: Findings from a Large Tertiary Care Referral Center" Open

Abby G. Meyers, Jennifer L. Hudson, CELESTE K. CRAVALHO, SAMANTHA MATTA, ALFREDO VILLALOBOS-PEREZ , et al. · 2020

Incorporation of the Ketogenic Diet in a Youth With Type 1 Diabetes Open

Fran R. Cogen · 2020

Before the discovery of insulin in 1922, treatment of diabetes was limited to palliative methods along with carbohydrate restriction. Bouchardat observed resolution of glycosuria with calorie-controlled diets as well as intermittent fasts …

Author response for "Metformin Treatment and Gastrointestinal Symptoms in Youth: Findings from a Large Tertiary Care Referral Center" Open

Abby G. Meyers, Jennifer L. Hudson, CELESTE K. CRAVALHO, SAMANTHA MATTA, ALFREDO VILLALOBOS-PEREZ , et al. · 2020

Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes Open

CELESTE K. CRAVALHO, Abby G. Meyers, LILIAN MABUNDO, Amber B. Courville, Shanna Yang , et al. · 2020

Blood pressure during sleep is associated with arterial stiffness and urine microalbumin to creatinine ratio in youth with type 1 diabetes Open

Evgenia Gourgari, Mihriye Méte, Margarita Dimatulac, Fran R. Cogen, Tammy M. Brady · 2020

Substance Use Among Adolescents and Young Adults With Type 1 Diabetes: Discussions in Routine Diabetes Care Open

Samantha P. Bento, MaryJane S. Campbell, Olivia Soutullo, Fran R. Cogen, Maureen Monaghan · 2020

Pediatric health care providers are in a unique position to discuss the health implications of alcohol, tobacco, and drug use with adolescents and young adults (AYAs) with type 1 diabetes (T1D). This study evaluated the frequency of self-r…

Diabetes-specific family conflict and responsibility among emerging adults with type 1 diabetes. Open

MaryJane S. Campbell, Jichuan Wang, Yao I. Cheng, Fran R. Cogen, Randi Streisand , et al. · 2019

Emerging adulthood is a transitional period for type 1 diabetes management, and aspects of family functioning such as family conflict and responsibility for diabetes management likely change following high school graduation. This study exa…

Low cholesterol efflux capacity and abnormal lipoprotein particles in youth with type 1 diabetes: a case control study Open

Evgenia Gourgari, Martin P. Playford, Umberto Campia, Amit K. Dey, Fran R. Cogen , et al. · 2018

Background Patients with type 1 diabetes (T1DM) have increased mortality from cardiovascular disease (CVD). Risk factors for CVD include an elevation of LDL (LDLp) and small HDL (sHDLp) particles, and a decrease in reverse cholesterol tran…

Acceptability and Feasibility of Examining Physical Activity in Young Children with Type 1 Diabetes Open

Carrie Tully, Miriam Toaff, Linda Herbert, Loretta DiPietro, Celia Henderson , et al. · 2017

Type 1 Diabetes: Urinary Proteomics and Protein Network Analysis Support Perturbation of Lysosomal Function Open

Harinder Singh, Yanbao Yu, Moo‐Jin Suh, Manolito Torralba, Robert D. Stenzel , et al. · 2017

While insulin replacement therapy restores the health and prevents the onset of diabetic complications (DC) for many decades, some T1D patients have elevated hemoglobin A1c values suggesting poor glycemic control, a risk factor of DC. We s…

The Feasibility of a Pilot Intervention for Parents of Young Children Newly Diagnosed With Type 1 Diabetes Open

Eleanor R. Mackey, Linda Herbert, Maureen Monaghan, Fran R. Cogen, Jichuan Wang , et al. · 2016

We evaluate the feasibility, acceptability, and indicators of preliminary efficacy of the pilot of a parent-focused, phone-based intervention to improve glycemic control and parental and child well-being in young children newly diagnosed w…

Self-Management Strategies in Emerging Adults With Type 1 Diabetes Open

Elora Majumder, Fran R. Cogen, Maureen Monaghan · 2016

Changes in type 1 diabetes health indicators from high school to college Open

Maureen Monaghan, Megan McCormick King, Vanessa Alvarez, Fran R. Cogen, Jichuan Wang · 2015

Diabetes health indicators are stable or decline upon college entrance. Results signal the need for targeted support for college students with type 1 diabetes.

<i>Checking In</i> Open

Maureen Monaghan, Lauren Clary, Priya Mehta, Alexa Stern, Christina Sharkey , et al. · 2015

Low-cost, translatable interventions to promote adherence in adolescents with type 1 diabetes are needed. This study evaluated a brief physician-delivered intervention designed to increase parent–adolescent communication about blood glucos…

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