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View article: Development and performance evaluation of a clinical metagenomics approach for identifying pathogens in the whole blood from patients with undifferentiated fever
Development and performance evaluation of a clinical metagenomics approach for identifying pathogens in the whole blood from patients with undifferentiated fever Open
Introduction Blood culture is the cornerstone of microbiological diagnostics for patients with acute undifferentiated fever and no obvious localization of infection; however, up to 50% of cases remain undiagnosed. Infections caused by arbo…
View article: Project Management Digitalisation of the Clinical Research at the University Medical Centre: Good Practice of using REDCap as a Digitalisation Tool
Project Management Digitalisation of the Clinical Research at the University Medical Centre: Good Practice of using REDCap as a Digitalisation Tool Open
The digitalisation of research processes using REDCap improved the organisation and execution of research, leading to greater efficiency and transparency, reduced administrative workload, and enhanced collaboration. This approach contribut…
View article: Balancing health and socioeconomic impacts: A uniform framework for evaluating non-pharmaceutical interventions
Balancing health and socioeconomic impacts: A uniform framework for evaluating non-pharmaceutical interventions Open
This paper introduces a uniform evaluation framework for assessing the effectiveness of past non-pharmaceutical interventions (NPIs) in managing infectious diseases, taking into account the cultural and social differences between countries…
View article: The choice of study designs of diagnostic accuracy using Borrelia specific IgG and IgM antibodies for the diagnosis of Lyme borreliosis
The choice of study designs of diagnostic accuracy using Borrelia specific IgG and IgM antibodies for the diagnosis of Lyme borreliosis Open
Case-control (two-gate design) studies, case series, and seroprevalence studies representing the range of LB in different populations are necessary to assess the diagnostic accuracy of serological tests for LB. A broader range of studies s…
View article: Lower Frequency of Multiple Erythema Migrans Skin Lesions in Lyme Reinfections, Europe
Lower Frequency of Multiple Erythema Migrans Skin Lesions in Lyme Reinfections, Europe Open
The erythema migrans (EM) skin lesion is the most common clinical manifestation of Lyme borreliosis. Information about EM in Lyme borreliosis reinfection is limited. Of the 12,384 cases with diagnosed EM at an outpatient clinic during 1990…
View article: Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence of <i>Borrelia burgdorferi</i>
Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence of <i>Borrelia burgdorferi</i> Open
Background In the United States, Borrelia burgdorferi ( Bb ) is the principal etiologic agent of Lyme disease. The complex structure of Bb genomes has posed challenges for genomic studies because homology among the bacterium’s many plasmid…
View article: P-1287. Incidence of Symptomatic Lyme Borreliosis in Nine European Countries, 2018−2022
P-1287. Incidence of Symptomatic Lyme Borreliosis in Nine European Countries, 2018−2022 Open
Background Lyme borreliosis (LB) is the most common tick-borne disease in Europe. Many European countries conduct LB surveillance. However, many symptomatic Bbsl infections are not detected by surveillance. The aim of this study was to est…
View article: Proportion of confirmed Lyme neuroborreliosis cases among adult patients with suspected early European Lyme neuroborreliosis
Proportion of confirmed Lyme neuroborreliosis cases among adult patients with suspected early European Lyme neuroborreliosis Open
View article: European human granulocytic anaplasmosis is caused by a subcluster of Anaplasma phagocytophilum Ecotype I
European human granulocytic anaplasmosis is caused by a subcluster of Anaplasma phagocytophilum Ecotype I Open
Anaplasma phagocytophilum causes human granulocytic anaplasmosis. However, despite its ubiquitous presence in animals and ticks, human cases are rarely reported in Europe. We generated genetic data from A. phagocytophilum fro…
View article: Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel
Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel Open
View article: Proportion of confirmed Lyme neuroborreliosis cases among patients with suspected early European Lyme neuroborreliosis
Proportion of confirmed Lyme neuroborreliosis cases among patients with suspected early European Lyme neuroborreliosis Open
Purpose To determine the frequency of confirmed Lyme neuroborreliosis (LNB) cases in adult patients with three different clinical presentations consistent with early LNB.Methods Data were obtained through routine health care at the UMC Lju…
View article: Acute Human Bocavirus 1 Infection in Children Hospitalized for Acute Bronchiolitis: A 2-Year Prospective Study
Acute Human Bocavirus 1 Infection in Children Hospitalized for Acute Bronchiolitis: A 2-Year Prospective Study Open
Background: The objective of this prospective study was to assess the proportion and clinical consequences of human bocavirus 1 (HBoV1) replication in children hospitalized for acute bronchiolitis (AB) with HBoV1 DNA in the nasopharynx (NP…
View article: Incidence of symptomatic Lyme borreliosis in nine European countries
Incidence of symptomatic Lyme borreliosis in nine European countries Open
View article: Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins
Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins Open
Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude and specificity of virus-specifi…
View article: Genetic variability in the glucocorticoid pathway and treatment outcomes in hospitalized patients with COVID-19: a pilot study
Genetic variability in the glucocorticoid pathway and treatment outcomes in hospitalized patients with COVID-19: a pilot study Open
Introduction: Corticosteroids are widely used for the treatment of coronavirus disease (COVID)-19. Genetic polymorphisms of the glucocorticoid receptor, metabolizing enzymes, or transporters may affect treatment response to dexamethasone. …
View article: Erythema Migrans in Patients with Post-Traumatic Splenectomy
Erythema Migrans in Patients with Post-Traumatic Splenectomy Open
Information on asplenic Lyme borreliosis (LB) patients with erythema migrans (EM) is lacking. We compared the course and outcome of 26 EM episodes in 24 post-trauma splenectomized patients (median age 51 years) diagnosed at a single clinic…
View article: Assessment of three criteria to establish borrelial infection in suspected lyme neuroborreliosis
Assessment of three criteria to establish borrelial infection in suspected lyme neuroborreliosis Open
Purpose Diagnosis of (European) Lyme neuroborreliosis has been based on clinical presentation, cerebrospinal fluid (CSF) pleocytosis and demonstration of intrathecal borrelial antibody synthesis (ITBAS) to document Borrelia burgdorferi s. …
View article: Elevated levels of serum muscle enzymes in the initial phase of tick-borne encephalitis
Elevated levels of serum muscle enzymes in the initial phase of tick-borne encephalitis Open
The present study exposes that in addition to previously known leukopenia, thrombocytopenia and increased liver enzymes activity, the initial phase of TBE is relatively often associated also with elevated muscle enzymes. Clinical relevance…
View article: Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity
Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity Open
Tick-borne encephalitis virus (TBEV) infection may cause acute central nervous system inflammation varying in clinical manifestations and severity. A possible correlation of TBEV-specific antibody and cell-mediated immune responses, shortl…
View article: Why Is the Duration of Erythema Migrans at Diagnosis Longer in Patients with Lyme Neuroborreliosis Than in Those without Neurologic Involvement?
Why Is the Duration of Erythema Migrans at Diagnosis Longer in Patients with Lyme Neuroborreliosis Than in Those without Neurologic Involvement? Open
In prior studies, the skin lesion erythema migrans (EM) was present for a longer time period before diagnosis of concomitant borrelial meningoradiculoneuritis (Bannwarth’s syndrome) compared to EM patients without neurologic symptoms. To d…
View article: Microbiologic Findings in a Cohort of Patients with Erythema Migrans
Microbiologic Findings in a Cohort of Patients with Erythema Migrans Open
Erythema migrans (EM) is the initial and the most frequent clinical manifestation of Lyme borreliosis (LB). Herein, we report on the capacity of culture and serology for the demonstration of Borrelia infection in a cohort of 292 patients d…
View article: Project Management Digitalisation of the Clinical Research at the University Medical Centre: Good Practice of Using Redcap as a Digitalization Tool
Project Management Digitalisation of the Clinical Research at the University Medical Centre: Good Practice of Using Redcap as a Digitalization Tool Open
View article: Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination Open
Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic element…
View article: COVID-19 and cholesterol biosynthesis: Towards innovative decision support systems
COVID-19 and cholesterol biosynthesis: Towards innovative decision support systems Open
View article: Dendritic cell activation and cytokine response in vaccine breakthrough TBE patients after in vitro stimulation with TBEV
Dendritic cell activation and cytokine response in vaccine breakthrough TBE patients after in vitro stimulation with TBEV Open
Tick-borne encephalitis (TBE) is a viral infection of the human central nervous system caused by the TBE virus (TBEV). The most effective protective measure against TBE is vaccination. Despite the highly immunogenic vaccine, cases of vacci…
View article: Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood
Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood Open
Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in…
View article: Are children with prolonged fever at a higher risk for serious illness? A prospective observational study
Are children with prolonged fever at a higher risk for serious illness? A prospective observational study Open
Objectives To describe the characteristics and clinical outcomes of children with fever ≥5 days presenting to emergency departments (EDs). Design Prospective observational study. Setting 12 European EDs. Patients Consecutive febrile childr…
View article: Molecular Typing of Mastadenoviruses in Simultaneously Collected Nasopharyngeal Swabs and Stool Samples from Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures
Molecular Typing of Mastadenoviruses in Simultaneously Collected Nasopharyngeal Swabs and Stool Samples from Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures Open
This study determines and compares the frequency of human mastadenovirus (HAdV) presence in children with acute bronchiolitis (AB), acute gastroenteritis (AGE), and febrile seizures (FS), ascertains types of HAdVs associated with each indi…
View article: Whole genome sequencing of<i>Borrelia burgdorferi</i>isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence
Whole genome sequencing of<i>Borrelia burgdorferi</i>isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence Open
Lyme disease is the most common vector-borne disease in North America and Europe. The clinical manifestations of Lyme disease vary based on the genospecies of the infecting Borrelia burgdorferi spirochete, but the microbial genetic element…
View article: A framework for estimating the socio-economic impacts of non-pharmaceutical interventions against COVID-19
A framework for estimating the socio-economic impacts of non-pharmaceutical interventions against COVID-19 Open
Non-pharmaceutical interventions against COVID-19 and other infectious diseases seek good trade-offs between reducing the number of infections and their socioeconomic costs. We propose a framework that establishes these costs from data on …