Frances S. de Man
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View article: The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction
The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction Open
Heart failure with preserved ejection fraction (HFpEF) is a growing global health problem characterized by high morbidity and mortality, with limited effective therapies available. Obesity significantly influences haemodynamic and structur…
View article: Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients
Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients Open
Aims Pre-capillary pulmonary hypertension (precPH) results in increased right atrial (RA) stretch and pressure. The right atrium is the major source of bone morphogenetic protein 10 (BMP10) in adults, primarily produced by RA cardiomyocyte…
View article: Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva
Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva Open
Background Fibrodysplasia ossificans progressiva (FOP) is caused by an activating mutation (p.R206H) in the type I BMP receptor ALK2, leading to heterotopic ossification (HO) in soft connective tissues. While aberrant Activin A-induced SMA…
View article: Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis
Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis Open
In contrast to acute responses, long-term treatment exerted little long-term afterload reduction and stroke volume augmentation in both HFpEF and HFrEF. Reverse remodeling was clearly present in HFrEF but was hardly observed in HFpEF. Thes…
View article: Kddnet: Knowledge and Data Dual-Driven Network for Infrared Small Ship Detection
Kddnet: Knowledge and Data Dual-Driven Network for Infrared Small Ship Detection Open
View article: Decoding Sex Differences in Right Ventricular Function through <i>BMPR1A</i>
Decoding Sex Differences in Right Ventricular Function through <i>BMPR1A</i> Open
View article: Targeting Fibrosis in Right Ventricular Pressure Overload: Balancing on a Tightrope?
Targeting Fibrosis in Right Ventricular Pressure Overload: Balancing on a Tightrope? Open
View article: Deep phenotyping of unaffected carriers of pathogenic<i>BMPR2</i>variants screened for pulmonary arterial hypertension
Deep phenotyping of unaffected carriers of pathogenic<i>BMPR2</i>variants screened for pulmonary arterial hypertension Open
Introduction Pathogenic variants in the gene encoding for BMPR2 are a major genetic risk factor for heritable pulmonary arterial hypertension. Owing to incomplete penetrance, deep phenotyping of unaffected carriers of a pathogenic BMPR2 va…
View article: Right ventricular diastolic adaptation to pressure overload in different rat strains
Right ventricular diastolic adaptation to pressure overload in different rat strains Open
Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been made to test differences in RV response to pressure overload between rat strains. We co…
View article: Targeting Soluble TGF-β Factors
Targeting Soluble TGF-β Factors Open
View article: Author Correction: Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts
Author Correction: Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts Open
View article: Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis
Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis Open
Background Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF. Trimetazidine has the potential to restore myocardial…
View article: Increased bone morphogenetic protein 10 in precapillary pulmonary hypertension patients
Increased bone morphogenetic protein 10 in precapillary pulmonary hypertension patients Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Netherlands Organization for Scientific Research: NWO-VICI num. 918.16.610 and NWO-VIDI num. 917.18.338. Dutch Heart Foundati…
View article: Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts
Mechanical stimulation of induced pluripotent stem cell derived cardiac fibroblasts Open
Cardiac fibrosis contributes to the development of heart failure, and is the response of cardiac fibroblasts (CFs) to pressure or volume overload. Limiting factors in CFs research are the poor availability of human cells and the tendency o…
View article: A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp> and the <scp>ESC</scp> Working Group on Pulmonary Circulation & Right Ventricular Function
A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (<span>HFA</span>) of the <span>ESC</span> and the <span>ESC</span> Working Group on Pulmonary Circulation & Right Ventricular Function Open
Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH‐LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimate…
View article: Evaluating the technical use of a Fitbit during an intervention for patients with pulmonary arterial hypertension with quality of life as primary endpoint: Lessons learned from the UPHILL study
Evaluating the technical use of a Fitbit during an intervention for patients with pulmonary arterial hypertension with quality of life as primary endpoint: Lessons learned from the UPHILL study Open
This article examines technical use of Fitbit during an intervention for pulmonary hypertension (PAH)‐patients. Technical issues with the device led to data being unavailable(37.5%). During intervention objective daily physical activity (D…
View article: Clinical Correlates of a Nonplexiform Vasculopathy in Patients With a Diagnosis of Idiopathic Pulmonary Arterial Hypertension
Clinical Correlates of a Nonplexiform Vasculopathy in Patients With a Diagnosis of Idiopathic Pulmonary Arterial Hypertension Open
This study revealed different vascular phenotypes within the current spectrum of patients with a diagnosis of IPAH, separated by clinical characteristics (age, sex, history of cigarette smoking, and diffusing capacity of the lungs for carb…
View article: Embedding routine health care data in clinical trials: with great power comes great responsibility
Embedding routine health care data in clinical trials: with great power comes great responsibility Open
View article: Effects of empagliflozin on right ventricular adaptation to pressure overload
Effects of empagliflozin on right ventricular adaptation to pressure overload Open
Background Right ventricular (RV) failure is the prime cause of death in patients with pulmonary arterial hypertension. Novel treatment strategies that protect the RV are needed. Empagliflozin, a sodium-glucose co-transporter-2 inhibitor, …
View article: Right ventricular to pulmonary arterial coupling in patients with repaired tetralogy of Fallot: a case series
Right ventricular to pulmonary arterial coupling in patients with repaired tetralogy of Fallot: a case series Open
Background In repaired tetralogy of Fallot (ToF) patients with residual right ventricular (RV) outflow tract obstructions (RVOTO), risk stratification and timing of re-interventions are based on RVOTO gradients. However, this might be insu…
View article: Long-term effects of pulmonary endarterectomy on pulmonary hemodynamics, cardiac function, and exercise capacity in chronic thromboembolic pulmonary hypertension
Long-term effects of pulmonary endarterectomy on pulmonary hemodynamics, cardiac function, and exercise capacity in chronic thromboembolic pulmonary hypertension Open
View article: Tricuspid regurgitation in pulmonary arterial hypertension: relations with right ventricular function and prognosis
Tricuspid regurgitation in pulmonary arterial hypertension: relations with right ventricular function and prognosis Open
Background Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive pulmonary vascular remodeling and increased pulmonary vascular resistance (PVR), subsequent right ventricular (RV) failure and premature…
View article: Right ventricular diastolic adaptation to pressure overload in different rat strains
Right ventricular diastolic adaptation to pressure overload in different rat strains Open
Background Different rat strains are used in various animal models of pulmonary hypertension and right ventricular (RV) failure. No systematic assessment has been performed to test differences in RV response to pressure overload between ra…
View article: Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome
Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome Open
Titin‐dependent stiffening of cardiomyocytes is a significant contributor to left ventricular (LV) diastolic dysfunction in heart failure with preserved LV ejection fraction (HFpEF). Small heat shock proteins (HSPs), such as HSPB5 and HSPB…
View article: The effects of empagliflozin on right ventricular adaptation to pressure overload
The effects of empagliflozin on right ventricular adaptation to pressure overload Open
Background Right ventricular (RV) failure is the prime cause of death in patients with pulmonary arterial hypertension. Novel treatment strategies that protect the RV are needed. Empagliflozin, a member of the new anti-diabetic sodium-gluc…
View article: Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension
Long-Term Effects of Pulmonary Endarterectomy on Right Ventricular Stiffness and Fibrosis in Chronic Thromboembolic Pulmonary Hypertension Open
BACKGROUND: Surgical removal of thromboembolic material by pulmonary endarterectomy (PEA) leads within months to the improvement of right ventricular (RV) function in the majority of patients with chronic thromboembolic pulmonary hypertens…
View article: Sex-biased TGFβ signalling in pulmonary arterial hypertension
Sex-biased TGFβ signalling in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are evident, which primarily presents with a female predominance and in…
View article: Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross‐over trial
Trimetazidine in heart failure with preserved ejection fraction: a randomized controlled cross‐over trial Open
Aims Impaired myocardial energy homeostasis plays an import role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Left ventricular relaxation has a high energy demand, and left ventricular diastolic dysfunc…
View article: Restoration of right ventricular function in the treatment of pulmonary arterial hypertension
Restoration of right ventricular function in the treatment of pulmonary arterial hypertension Open
Objective A 45% threshold of right ventricular ejection fraction (RVEF) is proposed clinically relevant in patients with pulmonary arterial hypertension (PAH). We aim to determine treatment response, long-term right ventricular (RV) functi…
View article: Right Atrial Adaptation to Precapillary Pulmonary Hypertension
Right Atrial Adaptation to Precapillary Pulmonary Hypertension Open
RA PV loops show increased RA stiffness and suggest atrioventricular uncoupling in patients with severe RV diastolic stiffness. Isolated RA cardiomyocytes of precPH patients are hypertrophied, without intrinsic sarcomeric changes. In end-s…