Francesca Amati
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View article: Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing
Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing Open
In the hypothalamus, detection of energy substrates such as glucose is essential to regulate food intake and peripheral energy homeostasis. Metabolic interactions between astrocytes and neurons via lactate exchange have been proposed as a …
View article: Preeclampsia as a Risk Factor of Postmenopausal Cardiovascular Disease: A Cross-Sectional Study
Preeclampsia as a Risk Factor of Postmenopausal Cardiovascular Disease: A Cross-Sectional Study Open
Introduction: Preeclampsia (PE) is a pregnancy-specific disorder characterized by hypertension and organ dysfunction, affecting 5–8% of pregnancies globally and increasing women’s long-term risk of cardiovascular disease (CVD). This study …
View article: Protocol to measure spontaneous locomotion, graded exercise oxygen consumption, and cross-sectional area of skeletal muscle cells in zebrafish
Protocol to measure spontaneous locomotion, graded exercise oxygen consumption, and cross-sectional area of skeletal muscle cells in zebrafish Open
View article: Correction: Contribution of fatigue experienced by Parkinson’s Disease patients on caregiver burden
Correction: Contribution of fatigue experienced by Parkinson’s Disease patients on caregiver burden Open
View article: The association of mitochondrial morphology and supercomplex redistribution with skeletal muscle oxidative capacity in older adults
The association of mitochondrial morphology and supercomplex redistribution with skeletal muscle oxidative capacity in older adults Open
Skeletal muscle maximal oxidative capacity (ATP max ) is a key component of age‐related sarcopenia and muscle health. The contribution of mitochondrial morphology and electron transport chain supercomplex (SC) assemblies to ATP max has yet…
View article: Mitochondrial dynamics: deciphering the role of HDL-C in regulating mitochondrial function and fatty acid oxidation in human skeletal muscle
Mitochondrial dynamics: deciphering the role of HDL-C in regulating mitochondrial function and fatty acid oxidation in human skeletal muscle Open
View article: Intersections and Challenges in the Management of Acute Coronary Syndrome and Stroke: Pathophysiology, Treatment Dilemmas, and Integrated Prevention Strategies
Intersections and Challenges in the Management of Acute Coronary Syndrome and Stroke: Pathophysiology, Treatment Dilemmas, and Integrated Prevention Strategies Open
Acute coronary syndrome (ACS) and stroke are interconnected conditions that often share risk factors such as atherosclerosis, thrombosis, and systemic inflammation. When these events occur simultaneously, they present unique diagnostic and…
View article: Closing the scissor-shaped curve: Strategies to promote gender equality in academia
Closing the scissor-shaped curve: Strategies to promote gender equality in academia Open
View article: Adherence to Pharmacotherapy in Post-Menopausal Women with Hypertension or Metabolic Syndrome: Real World Experience
Adherence to Pharmacotherapy in Post-Menopausal Women with Hypertension or Metabolic Syndrome: Real World Experience Open
Background: Adherence to medications is dependent upon a variety of factors, including individual characteristics of the patient, interactions with health care providers, and medication complexity. Even though several studies were conducte…
View article: Association between metabolic syndrome, hypertension, and chronic depression: a postmenopausal women prevention study
Association between metabolic syndrome, hypertension, and chronic depression: a postmenopausal women prevention study Open
Background. Chronic depression (CD) is common among postmenopausal women and is associated with an increased risk of cardiovascular disease (CVD). The diagnosis of CD is a challenging problem in clinical practice which is vastly underdiagn…
View article: Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy Open
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can a…
View article: Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock Open
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcripto…
View article: Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids
Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids Open
View article: 5 ADHERENCE TO PHARMACOTHERAPY IN POSTMENOPAUSAL WOMEN AFFECTED BY HYPERTENSION OR METABOLIC SYMDROME: REAL WORLD EXPERIENCE
5 ADHERENCE TO PHARMACOTHERAPY IN POSTMENOPAUSAL WOMEN AFFECTED BY HYPERTENSION OR METABOLIC SYMDROME: REAL WORLD EXPERIENCE Open
Objectives The aim of our study is to assess the adherence to pharmacological therapy in two different setting of patients, referred to our Heart Stations by General Practitioners and to value the relationship between different levels of c…
View article: 694 DRUG INDUCED KIDNEY INFARCTION: A CASE REPORT
694 DRUG INDUCED KIDNEY INFARCTION: A CASE REPORT Open
Isotretinoin (ISO) is a synthetic analog of vitamin A. Notwithstanding the well-known long-term efficacy in the treatment of severe resistant cystic acne, ISO induces several side effects too. Dyslipidemia, increased liver enzymes, as well…
View article: 550 FINGOLIMOD IN MULTIPLE SCLEROSIS: BRADYCARDIA, ATRIOVENTRICULAR BLOCKS AND EFFECT ON THE QT-INTERVAL. A PROSPECTIVE STUDY.
550 FINGOLIMOD IN MULTIPLE SCLEROSIS: BRADYCARDIA, ATRIOVENTRICULAR BLOCKS AND EFFECT ON THE QT-INTERVAL. A PROSPECTIVE STUDY. Open
Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) that is mainly characterized by inflammatory demyelination, leading to severe neurological disability. MS typically affects young adults and usuall…
View article: Biosensors in cardiology. T-CARE project: a preliminary study on an innovative wearable telemonitoring system
Biosensors in cardiology. T-CARE project: a preliminary study on an innovative wearable telemonitoring system Open
Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): REGIONE PUGLIA Introduction The demographic trend evolution and the modification of health needs highlight the requirement for a novel organiz…
View article: The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio Open
Significance The hypocretin (Hcrt, also known as orexin) neuropeptides regulate sleep and wake stability, and disturbances of Hcrt can lead to sleep disorders. MicroRNAs (miRNAs) are short noncoding RNAs that fine-tune protein expression l…
View article: Brain lipid metabolism: the emerging role of lipid droplets in glial cells
Brain lipid metabolism: the emerging role of lipid droplets in glial cells Open
Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland Correspondence to Francesca Amati, Department of Biomedical Sciences, University of Lausanne, Bugnon 7, 1005 Lausanne, Switzerland. Tel: +41 21 692 5552; e-ma…
View article: 124 Tiny but useful transportable remote monitoring device during SARS-CoV-2 pandemic
124 Tiny but useful transportable remote monitoring device during SARS-CoV-2 pandemic Open
A 45-year-old woman, without cardiovascular risk factors and affected by chronic migraine, presented to the emergency department due to the onset of a typical chest pain. After performing an electrocardiogram she was promptly transported t…
View article: Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore Open
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potass…
View article: Author response: Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
Author response: Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Cell-pene…
View article: Variants in <i>USP48</i> encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss
Variants in <i>USP48</i> encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss Open
Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals…
View article: Classical homocystinuria, is it safe to exercise?
Classical homocystinuria, is it safe to exercise? Open
View article: Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish Open
The oxidative phosphorylation (OXPHOS) system is a dynamic system in which the respiratory complexes coexist with super-assembled quaternary structures called supercomplexes (SCs). The physiological role of SCs is still disputed. Here, we …
View article: A novel approach to measure mitochondrial respiration in frozen biological samples
A novel approach to measure mitochondrial respiration in frozen biological samples Open
View article: Spastin mutations impair coordination between lipid droplet dispersion and reticulum
Spastin mutations impair coordination between lipid droplet dispersion and reticulum Open
Lipid droplets (LD) are affected in multiple human disorders. These highly dynamic organelles are involved in many cellular roles. While their intracellular dispersion is crucial to ensure their function and other organelles-contact, under…
View article: Energy, Nutrient and Food Intakes of Male Shift Workers Vary According to the Schedule Type but Not the Number of Nights Worked
Energy, Nutrient and Food Intakes of Male Shift Workers Vary According to the Schedule Type but Not the Number of Nights Worked Open
Shift work is associated with increased risk of chronic diseases due to circadian rhythm disruptions and behavioral changes such as in eating habits. Impact of type of shifts and number of night shifts on energy, nutrient and food intake i…
View article: Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore Open
Cell-penetrating peptides (CPPs) allow intracellular delivery of cargo molecules. They provide efficient methodology to transfer bioactive molecules in cells, in particular in conditions when transcription or translation of cargo-encoding …
View article: Renal tubular arginase‐2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia‐reperfusion injury in mice
Renal tubular arginase‐2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia‐reperfusion injury in mice Open
Aim Arginase 2 (ARG2) is a mitochondrial enzyme that catalyses hydrolysis of l ‐arginine into urea and l ‐ornithine. In the kidney, ARG2 is localized to the S3 segment of the proximal tubule. It has been shown that expression and activity …