Francesca Ciccarone
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View article: Diagnostic performance of ultrasound-guided biopsy for detecting recurrent or persistent cervical cancer after chemoradiotherapy: a prospective, single-center study
Diagnostic performance of ultrasound-guided biopsy for detecting recurrent or persistent cervical cancer after chemoradiotherapy: a prospective, single-center study Open
Ultrasound-guided biopsy appeared to be a feasible method for histologic confirmation in suspected persistent or recurrent cervical cancer after chemoradiotherapy. It demonstrated superior diagnostic accuracy over per-vagina biopsy and hol…
View article: Beyond Medical Care: Exploring Socio-Psychological Distress, Violence, and Food Insecurity among Gynecological Patients
Beyond Medical Care: Exploring Socio-Psychological Distress, Violence, and Food Insecurity among Gynecological Patients Open
BACKGROUND Gynecological conditions significantly impact emotional well-being, relationships, and overall quality of life, alongside presenting medical challenges [1]. Anxiety, depression, and stress due to concerns about diagnosis, treatm…
View article: Psychological distress, body image, and nutritional status during hospitalization for gynecological cancer surgery: a prospective observational study
Psychological distress, body image, and nutritional status during hospitalization for gynecological cancer surgery: a prospective observational study Open
Background Hospitalization for gynecological cancer surgery represents a critical window for assessing and addressing psychological and nutritional vulnerabilities. This prospective observational study investigated changes in emotional dis…
View article: Socio-psychological distress, violence, and food insecurity in women undergoing gynecological examinations: insights from a cross-sectional study of an Italian Tertiary Clinic
Socio-psychological distress, violence, and food insecurity in women undergoing gynecological examinations: insights from a cross-sectional study of an Italian Tertiary Clinic Open
View article: External validation of ultrasound-based models for differentiating between benign and malignant adnexal masses: a nationwide prospective multicenter study (IOTA phase 6)
External validation of ultrasound-based models for differentiating between benign and malignant adnexal masses: a nationwide prospective multicenter study (IOTA phase 6) Open
Risk of Malignancy Index had lower ability than the International Ovarian Tumor Analysis models to distinguish between benign and malignant adnexal tumors in patients examined by either expert or nonexpert ultrasound operators in Italy. Al…
View article: Imaging in gynecological disease (28): clinical and ultrasound characteristics of serous and mucinous cystadenomas in the adnexa
Imaging in gynecological disease (28): clinical and ultrasound characteristics of serous and mucinous cystadenomas in the adnexa Open
Objective To describe the clinical and ultrasound characteristics of serous and mucinous cystadenomas in the adnexa. Methods This was a retrospective international multicenter study. Using the International Ovarian Tumor Analysis (IOTA) da…
View article: Implications of Fumarate Hydratase Deficiency (FHD) and Cancer Risk: A Window into the Clinical and Oncological Implications of a Rare Disorder in Gynecology
Implications of Fumarate Hydratase Deficiency (FHD) and Cancer Risk: A Window into the Clinical and Oncological Implications of a Rare Disorder in Gynecology Open
Fumarate hydratase (FH) deficiency is a rare, yet impactful metabolic disorder caused by mutations in the FH gene, affecting the Krebs cycle, leading to the accumulation of fumarate and pseudohypoxic states. This metabolic shift promotes c…
View article: Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series
Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series Open
View article: External validation of ultrasound-based models for discrimination between benign and malignant adnexal masses in Italy: the prospective multicenter IOTA phase 6 study
External validation of ultrasound-based models for discrimination between benign and malignant adnexal masses in Italy: the prospective multicenter IOTA phase 6 study Open
Objective To prospectively validate the performance of the Risk of Malignancy Index (RMI), International Ovarian Tumor Analysis (IOTA) Simple Rules Risk Model (SRRisk), IOTA Assessment of Different NEoplasias in the adneXa (ADNEX) and the …
View article: Role of artificial intelligence applied to ultrasound in gynecology oncology: A systematic review
Role of artificial intelligence applied to ultrasound in gynecology oncology: A systematic review Open
The aim of this paper was to explore the role of artificial intelligence (AI) applied to ultrasound imaging in gynecology oncology. Web of Science, PubMed, and Scopus databases were searched. All studies were imported to RAYYAN QCRI softwa…
View article: Radiomics analysis of ultrasound images to discriminate between benign and malignant adnexal masses with solid morphology on ultrasound
Radiomics analysis of ultrasound images to discriminate between benign and malignant adnexal masses with solid morphology on ultrasound Open
Objective The primary aim was to identify radiomics ultrasound features that can distinguish between benign and malignant adnexal masses with solid ultrasound morphology, and between primary malignant (including borderline and primary inva…
View article: Innovative Ultrasound Criteria for the Diagnosis of Adenomyosis and Correlation with Symptoms: A Retrospective Re-Evaluation
Innovative Ultrasound Criteria for the Diagnosis of Adenomyosis and Correlation with Symptoms: A Retrospective Re-Evaluation Open
The 2022 Delphi revision of the MUSA (Morphological Uterus Sonographic Assessment) criteria for the ultrasound diagnosis of adenomyosis divides the ultrasound signs for diagnosis into direct and indirect ones, considering the presence of a…
View article: A cost-effectiveness analysis of an integrated clinical-radiogenomic screening program for the identification of BRCA 1/2 carriers (e-PROBE study)
A cost-effectiveness analysis of an integrated clinical-radiogenomic screening program for the identification of BRCA 1/2 carriers (e-PROBE study) Open
Current approach to identify BRCA 1/2 carriers in the general population is ineffective as most of the carriers remain undiagnosed. Radiomics is an emerging tool for large scale quantitative analysis of features from standard diagnostic im…
View article: EP26.08: Imaging in gynecological disease: clinical and ultrasound characteristics of uterine malignant mixed Müllerian tumours
EP26.08: Imaging in gynecological disease: clinical and ultrasound characteristics of uterine malignant mixed Müllerian tumours Open
Objectives: ACUM or ''Accessory Cavitated Uterine Malformation'' is a relatively rare and recently recognised uterine abnormality.It has been defined as a non-communicating accessory uterine cavity with functional endometrium, located at t…
View article: OP14.04: Ultrasound‐based radiomics analysis for discriminating between benign and malignant ovarian masses with solid ultrasound morphology
OP14.04: Ultrasound‐based radiomics analysis for discriminating between benign and malignant ovarian masses with solid ultrasound morphology Open
To develop and validate an ultrasound-based clinical-radiomic model to discriminate between benign and malignant adnexal masses with solid ultrasound morphology. This is a retrospective observational study. Patients with a histological dia…
View article: OP09.03: Tailgut cyst mistaken for pelvic endometriotic nodule: a case report
OP09.03: Tailgut cyst mistaken for pelvic endometriotic nodule: a case report Open
Tailgut cysts (or rectal cyst hamartomas) are retrorectal developmental cysts. They originate from the tailgut and embryological remnants of neuroenteric canal in the presacral-retrorectal space. At macroscopy, they are usually multilocula…
View article: OC12.02: Clinical and ultrasound characteristics of granulosa cell and Sertoli Leydig cell tumour recurrences
OC12.02: Clinical and ultrasound characteristics of granulosa cell and Sertoli Leydig cell tumour recurrences Open
To describe the ultrasound characteristics of granulosa cell and Sertoli Leydig cell tumour recurrences. This is a single centre retrospective observational study. Patients with a histological diagnosis of recurrent granulosa cell or Serto…
View article: Imaging in gynecological disease (27): clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
Imaging in gynecological disease (27): clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors Open
Objective To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli–Leydig cell tumors. Methods This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli…
View article: #119 Prediction of germline brca 1/2 genes pathogenetic variants from healthy ovaries ultrasound images: radiogenomics as an innovative tool to prevent BRCA-related cancers
#119 Prediction of germline brca 1/2 genes pathogenetic variants from healthy ovaries ultrasound images: radiogenomics as an innovative tool to prevent BRCA-related cancers Open
Introduction/Background Current indications for BRCA 1/2 testing based on a priori BRCA probability thresholds are ineffective as most of the carriers remain undiagnosed. Data regarding the cost-effectiveness of a population-based BRCA mut…
View article: An Integrated Clinical-radiogenomic Screening Programfor the Identification of Brca 1/2 Carriers: a Cost-effectiveness Analysis (E-probe Study)
An Integrated Clinical-radiogenomic Screening Programfor the Identification of Brca 1/2 Carriers: a Cost-effectiveness Analysis (E-probe Study) Open
Importance: Current approach to identify BRCA 1/2 carriers in the general population is ineffective as most of the carriers remain undiagnosed. Radiomics is an emerging tool for large scale quantitative analysis of features from standard d…
View article: Use of oral GnRH antagonists combined therapy in the management of symptomatic uterine fibroids
Use of oral GnRH antagonists combined therapy in the management of symptomatic uterine fibroids Open
Uterine fibroids have an impact on women’s lives due to their high prevalence, physical symptoms, their consequences on patients’ emotional and psychological well-being and loss of work productivity. The choice of therapeutical approaches …
View article: Preoperative Tumor Texture Analysis on MRI for High-Risk Disease Prediction in Endometrial Cancer: A Hypothesis-Generating Study
Preoperative Tumor Texture Analysis on MRI for High-Risk Disease Prediction in Endometrial Cancer: A Hypothesis-Generating Study Open
Objective: To develop and validate magnetic resonance (MR) imaging-based radiomics models for high-risk endometrial cancer (EC) prediction preoperatively, to be able to estimate deep myometrial invasion (DMI) and lymphovascular space invas…
View article: 27P Clinical relevance of NGS analysis in endometrial cancer (EC) management
27P Clinical relevance of NGS analysis in endometrial cancer (EC) management Open
View article: Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis
Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis Open
Uterine leiomyosarcomas (uLMS) is a very rare disease, and patients experience a dismal prognosis even when treated with chemotherapy. Therefore, a more in-depth molecular characterization of this disease could provide suitable data for th…
View article: PARP Inhibitors Resistance: Mechanisms and Perspectives
PARP Inhibitors Resistance: Mechanisms and Perspectives Open
PolyADP-ribose polymerase (PARP) inhibitors (PARPis) represent the first clinically approved drugs able to provoke “synthetic lethality” in patients with homologous recombination-deficient (HRD) tumors. Four PARPis have just received appro…
View article: Endoscopic ultrasound-guided radiofrequency ablation of recurrent cervical cancer in the pelvis untreatable by radiation therapy
Endoscopic ultrasound-guided radiofrequency ablation of recurrent cervical cancer in the pelvis untreatable by radiation therapy Open
A 75-year-old woman with a history of squamous cell carcinoma of the cervix (FIGO staging IIa: T2a, N0, M0) was treated with neoadjuvant platinum-based chemotherapy, followed by laparoscopic bilateral hysteroannessiectomy and bilateral pel…
View article: Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic
Risk perception and affective state on work exhaustion in obstetrics during the COVID-19 pandemic Open
A multicenter cross-sectional survey study involving four Italian University Hospitals was performed to test the hypothesis that negative affect and positive affect (affective dimensions) mediate the association between risk perception (pe…
View article: An Integrated Clinico-Radiogenomic Screening Program for the Identification of BRCA 1/2 Carriers: A Cost-Effectiveness Analysis(e-PROBE Study)
An Integrated Clinico-Radiogenomic Screening Program for the Identification of BRCA 1/2 Carriers: A Cost-Effectiveness Analysis(e-PROBE Study) Open
View article: Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital
Building a Personalized Medicine Infrastructure for Gynecological Oncology Patients in a High-Volume Hospital Open
Gynecological cancers require complex intervention since patients have specific needs to be addressed. Centralization to high-volume centers improves the oncological outcomes of patients with gynecological cancers. Research in gynecologica…
View article: Ultrasound, macroscopic and histological features of malignant ovarian tumors. Metastatic tumors to the ovary: ovarian metastases from biliary tract and ovarian metastases from colon cancer
Ultrasound, macroscopic and histological features of malignant ovarian tumors. Metastatic tumors to the ovary: ovarian metastases from biliary tract and ovarian metastases from colon cancer Open