Francesca Natale
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View article: Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke
Intranasal delivery of extracellular vesicles derived from human bone marrow mesenchymal stem cells dampens neuroinflammation and ameliorates motor deficits in a mouse model of cortical stroke Open
Early treatment of ischemic stroke can significantly reduce disability and mortality rates. Stem cell-derived extracellular vesicles (EVs) have shown potential as therapeutics for neurological disorders. This study explored whether intrana…
View article: Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease
Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease Open
Protein post-translational modifications (PTM) play a crucial role in the modulation of synaptic function and their alterations are involved in the onset and progression of neurodegenerative disorders. S-palmitoylation is a PTM catalyzed b…
View article: High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes
High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes Open
View article: Olfactory stimulation with multiple odorants prevents stress-induced cognitive and psychological alterations
Olfactory stimulation with multiple odorants prevents stress-induced cognitive and psychological alterations Open
Acute and chronic stress markedly affects behavior by triggering sympathetic nervous system activation and several hypothalamus-pituitary-adrenal-dependent responses. Brain regions of the limbic system are responsible for the regulation of…
View article: Palmitoyl transferase zDHHCs: novel targets in Alzheimer’s disease
Palmitoyl transferase zDHHCs: novel targets in Alzheimer’s disease Open
Background Growing evidence points to altered metabolic signals as a risk factor for Alzheimer’s disease (AD). The high fatty acid levels and brain insulin resistance (BIR) found in AD brains may impinge on protein S‐palmitoylation, which …
View article: On the Performativity of Disinterested Attention for the Experience of Contemporary Art
On the Performativity of Disinterested Attention for the Experience of Contemporary Art Open
The aim of this article is to point out that attentional practices don’t simply overlap with control and action/reaction dynamics; they are also strictly connected to non-productivity, non-instrumentality, disinterestedness, contemplation …
View article: Maternal High Fat Diet Multigenerationally Impairs Hippocampal Adult Neurogenesis
Maternal High Fat Diet Multigenerationally Impairs Hippocampal Adult Neurogenesis Open
Metabolic dysregulation harms brain health. Early-life (pre- and perinatal) dysmetabolic stimuli have been demonstrated to affect central nervous system (CNS), multigenerationally impairing brain plasticity and cognitive functions in adult…
View article: Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of Aβ Metabolism
Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of Aβ Metabolism Open
Maternal overnutrition has been reported to affect brain plasticity of the offspring by altering gene expression, regulating both synaptic plasticity and adult neurogenesis. However, whether perinatal metabolic stress may influence the acc…
View article: Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules
Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules Open
View article: High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms Open
Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult ne…
View article: Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference
Hippocampal Estrogen Signaling Mediates Sex Differences in Retroactive Interference Open
Despite being a crucial physiological function of the brain, the mechanisms underlying forgetting are still poorly understood. Estrogens play a critical role in different brain functions, including memory. However, the effects of sex hormo…
View article: 500 EFFECTS OF COVID-19 PANDEMICS ON SYMPTOMS AND QUALITY OF LIFE IN PATIENTS AFFECTED BY INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS) AND IRRITABLE BOWEL SYNDROME (IBS)
500 EFFECTS OF COVID-19 PANDEMICS ON SYMPTOMS AND QUALITY OF LIFE IN PATIENTS AFFECTED BY INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME (IC/PBS) AND IRRITABLE BOWEL SYNDROME (IBS) Open
View article: Immersive environments: fragmented and discontinuous spaces for action and art
Immersive environments: fragmented and discontinuous spaces for action and art Open
The spectator of contemporary art is located in a special operating space during an exhibition, where he/she can participate, take action, modify, intervene, expand: nevertheless, is the possibility of action really the main feature of a w…
View article: Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche
Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche Open
Neural stem and progenitor cell (NSPC) depletion may play a crucial role in the cognitive impairment observed in many age-related non-communicable diseases. Insulin resistance affects brain functions through a plethora of mechanisms that r…
View article: High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures
High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures Open
The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake …
View article: Neural Stem Cell-Derived Exosomes Revert HFD-Dependent Memory Impairment via CREB-BDNF Signalling
Neural Stem Cell-Derived Exosomes Revert HFD-Dependent Memory Impairment via CREB-BDNF Signalling Open
Overnutrition and metabolic disorders impair cognitive functions through molecular mechanisms still poorly understood. In mice fed with a high fat diet (HFD) we analysed the expression of synaptic plasticity-related genes and the activatio…
View article: Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4
Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4 Open
Glucose metabolism derangement is critically involved in the age-related memory loss but the underlying molecular mechanisms are still poorly understood. In a mouse model of type 1 diabetes we found memory impairment associated with inhibi…
View article: Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models
Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models Open
Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer’s disease. We have explored whether …
View article: Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms Open
View article: Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Open
View article: NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease Open
Disarrangement in functions and quality control of mitochondria at synapses are early events in Alzheimer's disease (AD) pathobiology. We reported that a 20-22 kDa NH2-tau fragment mapping between 26 and 230 amino acids of the longest huma…