Francesca Rigotti
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Data from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironme…
Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia Open
Cachexia is a major cause of morbidity and mortality in individuals with cancer and is characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white adipose tissue (WAT) remodeling, which often precedes weight l…
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletel…
Supplementary material from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
It includes extended material and methods, and supplementary figures
Supplementary material from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
It includes extended material and methods, and supplementary figures
Data from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironme…
Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironme…
HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletel…
Endothelial Rbpj is essential for the education of tumour-associated macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynaecological cancers worldwide. EOC cells educate tumour-associated macrophages (TAMs) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumour microenv…
Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function Open
Objective Fibrotic organ responses have recently been identified as long-term complication in diabetes. Indeed, insulin resistance and aberrant hepatic lipid accumulation represent driving features of progressive non-alcoholic fatty liver …
Semaphorin 3C exacerbates liver fibrosis Open
Background & Aims Chronic liver disease is a growing epidemic leading to fibrosis and cirrhosis. TGF-β is the pivotal pro-fibrogenic cytokine which activates hepatic stellate cells (HSC), yet, other molecules can substantially modulate TGF…
Synthesis of Silver Modified Bioactive Glassy Materials with Antibacterial Properties via Facile and Low-Temperature Route Open
There is an increasing clinical need to develop novel biomaterials that combine regenerative and biocidal properties. In this work, we present the preparation of silver/silica-based glassy bioactive (ABG) compositions via a facile, fast (2…
Synthesis of Silver Modified Bioactive Glassy Materials with Antibacterial Properties via Facile and Low-Temperature Route Open
There is an increasing clinical need to develop novel biomaterials that combine regenerative and biocidal properties. In this work, we present the preparation of silver /silica based glassy bioactive (ABG) compositions via a facile, fast (…
MARCH9‐mediated ubiquitination regulates MHC I export from the TGN Open
Given the heterogeneous nature of antigens, major histocompatibility complex class I (MHC I) intracellular transport intersects with multiple degradation pathways for efficient peptide loading and presentation to cytotoxic T cells. MHC I l…