Francesca Vasile
YOU?
Author Swipe
View article: A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor
A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor Open
Excessive signaling by various GPCRs underlies a variety of human disorders. Suppression of GPCRs by "enhanced" arrestin mutants was proposed as therapy. We hypothesized that GPCR binding of endogenous arrestins can be increased by small m…
View article: Prediction Of Labor Outcome Using Generative Artificial Intelligence
Prediction Of Labor Outcome Using Generative Artificial Intelligence Open
View article: A small molecule enhances arrestin-3 binding to the β<sub>2</sub>-adrenergic receptor
A small molecule enhances arrestin-3 binding to the β<sub>2</sub>-adrenergic receptor Open
G protein-coupled receptor (GPCR) signaling is terminated by arrestin binding to a phosphorylated receptor. Binding propensity has been shown to be modulated by stabilizing the pre-activated state of arrestin through point mutations or C-t…
View article: Peptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR–Small Molecule Complexes
Peptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR–Small Molecule Complexes Open
Ribonucleic acid (RNA)-binding proteins (RBPs) play a key role in regulating RNA stability, fate, function, gene expression, post-transcriptional modifications, and cellular activities. Among the various RBPs identified to date, the Hu pro…
View article: Total Synthesis of an Epothilone Analogue Based on the Amide‐Triazole Bioisosterism
Total Synthesis of an Epothilone Analogue Based on the Amide‐Triazole Bioisosterism Open
Epothilones are 16‐membered macrolides that act as microtubule‐targeting agents to tackle cancer. Many synthetic analogues have been investigated for their activity, yet often based on macrolide structures. A notable exception is Ixabepilo…
View article: Biophysical Assays for Investigating Modulators of Macromolecular Complexes: An Overview
Biophysical Assays for Investigating Modulators of Macromolecular Complexes: An Overview Open
Drug discovery is a lengthy and intricate process, and in its early stage, crucial steps are the selection of the therapeutic target and the identification of novel ligands. Most targets are dysregulated in pathogenic cells; typically, the…
View article: Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization
Identification of HuR–RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization Open
The RNA binding protein HuR regulates the post-transcriptional process of different oncogenes and tumor suppressor genes, and its dysregulation is linked with cancer. Thus, modulating the complex HuR-RNA represents a promising anticancer s…
View article: GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro
GM1 oligosaccharide efficacy against α-synuclein aggregation and toxicity in vitro Open
View article: CCDC 2205296: Experimental Crystal Structure Determination
CCDC 2205296: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis of Tetrasubstituted Nitroalkenes and Preliminary Studies of Their Enantioselective Organocatalytic Reduction
Synthesis of Tetrasubstituted Nitroalkenes and Preliminary Studies of Their Enantioselective Organocatalytic Reduction Open
Starting from commercially available ketones, a reproducible and reliable strategy for the synthesis of tetrasubstituted nitroalkenes was successfully developed, using a two-step procedure; the HWE olefination of the ketone to form the cor…
View article: Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from Burkholderia cenocepacia
Identification of New L-Fucosyl and L-Galactosyl Amides as Glycomimetic Ligands of TNF Lectin Domain of BC2L-C from Burkholderia cenocepacia Open
The inhibition of carbohydrate-lectin interactions is being explored as an efficient approach to anti adhesion therapy and biofilm destabilization, two alternative antimicrobial strategies that are being explored against resistant pathogen…
View article: Front Cover: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (Chem. Eur. J. 5/2023)
Front Cover: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (Chem. Eur. J. 5/2023) Open
Work with the elements of nature: Our building block, maytansinol, represented as a constellation of stars, is the main protagonist of the story. A ray of light coming out from it demonstrates how different moieties can be attached to it, …
View article: Highly Conjugated Bis(benzo[<i>b</i>]phosphole)‐<i>P</i>‐oxides: Synthesis and Electrochemical, Optical, and Computational Studies
Highly Conjugated Bis(benzo[<i>b</i>]phosphole)‐<i>P</i>‐oxides: Synthesis and Electrochemical, Optical, and Computational Studies Open
The first examples of a π‐conjugated benzo[ b ]phosphole P ‐oxide in which two phosphole P ‐oxide units are connected by a carbon‐carbon double bond are described. The molecules are synthesized as E isomers with respect to the carbon‐carbo…
View article: Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics Open
Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the com…
View article: Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin
Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin Open
View article: Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of <i>Burkholderia cenocepacia</i>’s BC2L-C Lectin
Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of <i>Burkholderia cenocepacia</i>’s BC2L-C Lectin Open
Multidrug-resistant pathogens such as Burkholderia cenocepacia have become a hazard in the context of healthcare-associated infections, especially for patients admitted with cystic fibrosis or immuno-compromising conditions. Like ot…
View article: Pt‐WO<sub>x</sub>/C Catalysts for α, β‐Unsaturated Aldehydes Hydrogenation: An NMR Study of the Effect of the Reactant Adsorption on Activity and Selectivity
Pt‐WO<sub>x</sub>/C Catalysts for α, β‐Unsaturated Aldehydes Hydrogenation: An NMR Study of the Effect of the Reactant Adsorption on Activity and Selectivity Open
The selective hydrogenation of α,β‐unsaturated aldehydes is an ideal case for studying the structure‐activity relationships in heterogeneous catalysis. In particular, cinnamaldehyde can be used as probe molecule for revealing the competiti…
View article: A combined fragment-based virtual screening and STD-NMR approach for the identification of E-cadherin ligands
A combined fragment-based virtual screening and STD-NMR approach for the identification of E-cadherin ligands Open
Cadherins promote cell-cell adhesion by forming homophilic interactions via their N-terminal extracellular domains. Hence, they have broad-ranging physiological effects on tissue organization and homeostasis. When dysregulated, cadherins c…
View article: New Chemotypes for the Inhibition of (p)ppGpp Synthesis in the Quest for New Antimicrobial Compounds
New Chemotypes for the Inhibition of (p)ppGpp Synthesis in the Quest for New Antimicrobial Compounds Open
Antimicrobial resistance (AMR) poses a serious threat to our society from both the medical and economic point of view, while the antibiotic discovery pipeline has been dwindling over the last decades. Targeting non-essential bacterial path…
View article: Synthesis, Stereochemical and Photophysical Properties of Functionalized Thiahelicenes
Synthesis, Stereochemical and Photophysical Properties of Functionalized Thiahelicenes Open
We report on the synthesis of a novel class of functionalized thia[6]helicenes and a thia[5]helicene, containing a benzothiophene unit and a second heteroatom embedded in the helix (i.e., nitrogen and oxygen) or a pyrene or a spirobifluore…
View article: An Insight into the Role of Reactant Structure Effect in Pd/C Catalysed Aldehyde Hydrogenation
An Insight into the Role of Reactant Structure Effect in Pd/C Catalysed Aldehyde Hydrogenation Open
The different activity of a 1% Pd/carbon catalyst towards aromatic and aliphatic aldehydes hydrogenation has been explored by 13C NMR relaxation. The ratio between T1 relaxation times of adsorbed (ads) and free diffusing (bulk) molecules (…
View article: 2SPD-029 Stability of nivolumab solutions after transport through pneumatic tube systems
2SPD-029 Stability of nivolumab solutions after transport through pneumatic tube systems Open
Background and importance The assessment of 'in-use' stability of biotechnological medicinal products is not typically required prior to regulatory approval. However, 'in-use' conditions (ie, handling, storage, transport) could compromise …
View article: Cover Feature: Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders (Chem. Eur. J. 2/2022)
Cover Feature: Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders (Chem. Eur. J. 2/2022) Open
The interdisciplinary character of the Horizon2020-MSCA-EJD TubInTrain project allowed a challenging study of the peculiarity of maytansinoids as tubulin binders. The enthusiasm of PhD students proved fundamental for productively merging s…
View article: Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders
Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders Open
Maytansinol is a valuable precursor for the preparation of maytansine derivatives (known as maytansinoids). Inspired by the intriguing structure of the macrocycle and the success in targeted cancer therapy of the derivatives, we explored t…
View article: Evaluation of a Pneumatic Tube System for Delivering Nivolumab Diluted Solutions
Evaluation of a Pneumatic Tube System for Delivering Nivolumab Diluted Solutions Open
Figure 1 SE HPLC overlay of diluted nivolumab sample before (blue line) and after transportation in bag with (red line) and without air PN (green line) at day 0.
View article: Managing Experimental 3D Structures in the Beyond‐Rule‐of‐5 Chemical Space: The Case of Rifampicin
Managing Experimental 3D Structures in the Beyond‐Rule‐of‐5 Chemical Space: The Case of Rifampicin Open
The beyond‐Rule‐of‐5 (bRo5) chemical space is a source of new oral drugs and includes large and flexible compounds. Because of their size and conformational variability, bRo5 molecules assume different privileged conformations in the compa…
View article: Chemical and Biophysical Approaches to Allosteric Modulation
Chemical and Biophysical Approaches to Allosteric Modulation Open
Allosteric regulation, i. e. the control exerted on an orthosteric site by an effector interacting at a distinct and distant site, represents a prime example of a precise tuning system of several key biological processes like gene transcri…
View article: Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant <i>Burkholderia cenocepacia</i> **
Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant <i>Burkholderia cenocepacia</i> ** Open
Burkholderia cenocepacia is an opportunistic Gram‐negative bacterium that causes infections in patients suffering from chronic granulomatous diseases and cystic fibrosis. It displays significant morbidity and mortality due to extreme resis…
View article: Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds
Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds Open
Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is t…
View article: Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia
Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia Open
We use a virtual screening approach to explore the binding pocket close to the fucose binding site in a lectin from opportunistic pathogen. This is a novel approach for designing anti-adhesive drugs, and it has been very successful since…