Francesco Brun
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View article: Optimising sample preparation to enhance contrast-to-noise ratio in X-ray phase contrast tomography white matter (WM) imaging of the central nervous system
Optimising sample preparation to enhance contrast-to-noise ratio in X-ray phase contrast tomography white matter (WM) imaging of the central nervous system Open
The choice of fixative is critical in X-ray phase-contrast tomography (XPCT) because it affects tissue preservation, contrast enhancement and compatibility with other imaging techniques. A careful selection and optimization of fixatives ca…
View article: Spectral phase-contrast X-ray imaging with high-resolution detectors
Spectral phase-contrast X-ray imaging with high-resolution detectors Open
X-ray phase contrast imaging (XPCI) records phase shifts in X-rays as they pass through matter, enabling the distinction of features, such as soft tissues, that have low contrast in conventional absorption-based methods. Phase contrast bea…
View article: Timepix4 spatial response characterization with X-ray monochromatic synchrotron beam
Timepix4 spatial response characterization with X-ray monochromatic synchrotron beam Open
The Timepix4 is a readout ASIC developed by the Medipix4 collaboration, designed to work with various semiconductor sensors to form detection systems with 448×512 pixels with a pitch of 55 µm. Its ability to simultaneously measure the Time…
View article: Hydrogel Elastic Energy: A Stressor Triggering an Adaptive Stress‐Mediated Cell Response
Hydrogel Elastic Energy: A Stressor Triggering an Adaptive Stress‐Mediated Cell Response Open
The crosstalk between the cells and the extracellular matrix (ECM) is bidirectional and consists of a pushing/pulling stretch exerted by the cells and a mechanical resistance counteracted by the surrounding microenvironment. It is widely r…
View article: The potential of x‐ray virtual histology in the diagnosis of skin tumors
The potential of x‐ray virtual histology in the diagnosis of skin tumors Open
Background Histopathological analysis represents the gold standard in clinical practice for diagnosing skin neoplasms. While the current diagnostic workflow has specialized in producing robust and accurate results, interpreting tissue arch…
View article: Timepix4 characterization with monochromatic X-rays at the Elettra synchrotron facility
Timepix4 characterization with monochromatic X-rays at the Elettra synchrotron facility Open
View article: Validation of Timepix4 energy calibration procedures with synchrotron X-ray beams
Validation of Timepix4 energy calibration procedures with synchrotron X-ray beams Open
The Timepix4 is an application-specific integrated circuit developed by the Medipix4 collaboration. The chip is a 448x512 matrix that can be connected, via bump-bonding, to pixelated sensors of various materials and thicknesses, forming ap…
View article: Quantitative spectral micro-CT of a CA4+ loaded osteochondral sample with a tabletop system
Quantitative spectral micro-CT of a CA4+ loaded osteochondral sample with a tabletop system Open
Micro-computed tomography ( $$\upmu$$ CT) is the gold standard for nondestructive 3D imaging of biomedical samples in the centimeter scale, but it has limited effectiveness in revealing intricate soft tissue details due to the limited at…
View article: The EuAPS Betatron Radiation Source: Status Update and Photon Science Perspectives
The EuAPS Betatron Radiation Source: Status Update and Photon Science Perspectives Open
The EuPRAXIA EU project is at the forefront of advancing particle accelerator research and the development of photon sources through innovative plasma acceleration approaches. Within this framework, the EuAPS project aims to exploit laser …
View article: Edge-illumination spectral phase-contrast tomography
Edge-illumination spectral phase-contrast tomography Open
Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination tech…
View article: Cell Activities on Viscoelastic Substrates Show an Elastic Energy Threshold and Correlate with the Linear Elastic Energy Loss in the Strain‐Softening Region
Cell Activities on Viscoelastic Substrates Show an Elastic Energy Threshold and Correlate with the Linear Elastic Energy Loss in the Strain‐Softening Region Open
Energy‐sensing in viscoelastic substrates has recently been shown to be an important regulator of cellular activities, modulating mechanical transmission and transduction processes. Here, this study fine‐tunes the elastic energy of viscoel…
View article: PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging
PEPI Lab: a flexible compact multi-modal setup for X-ray phase-contrast and spectral imaging Open
This paper presents a new flexible compact multi-modal imaging setup referred to as PEPI (Photon-counting Edge-illumination Phase-contrast imaging) Lab, which is based on the edge-illumination (EI) technique and a chromatic detector. The s…
View article: Micromorphology of pineal gland calcification in age‐related neurodegenerative diseases
Micromorphology of pineal gland calcification in age‐related neurodegenerative diseases Open
Background The formation of concrements in human pineal gland (PG) is a physiological process and, according to many researchers, is associated with the involution of PG structures. The majority of scientific publications concern progressi…
View article: Multi-material spectral photon-counting micro-CT with minimum residual decomposition and self-supervised deep denoising
Multi-material spectral photon-counting micro-CT with minimum residual decomposition and self-supervised deep denoising Open
Spectral micro-CT imaging with direct-detection energy discriminating photon counting detectors having small pixel size (< 100×100 µm 2 ) is mainly hampered by: i) the limited energy resolution of the imaging device due to charge sharing e…
View article: Lesion Extension and Neuronal Loss after Spinal Cord Injury Using X-Ray Phase-Contrast Tomography in Mice
Lesion Extension and Neuronal Loss after Spinal Cord Injury Using X-Ray Phase-Contrast Tomography in Mice Open
Following spinal cord injury (SCI) the degree of functional (motor, autonomous, or sensory) loss correlates with the severity of nervous tissue damage. An imaging technique able to capture non-invasively and simultaneously the complex mech…
View article: PyPore3D: An Open Source Software Tool for Imaging Data Processing and Analysis of Porous and Multiphase Media
PyPore3D: An Open Source Software Tool for Imaging Data Processing and Analysis of Porous and Multiphase Media Open
In this work, we propose the software library PyPore3D, an open source solution for data processing of large 3D/4D tomographic data sets. PyPore3D is based on the Pore3D core library, developed thanks to the collaboration between Elettra S…
View article: Regulation of Substrate Dissipation via Tunable Linear Elasticity Controls Cell Activity
Regulation of Substrate Dissipation via Tunable Linear Elasticity Controls Cell Activity Open
Natural tissues and extracellular matrices (ECMs) are not purely elastic materials but exhibit dissipative properties. Although it has recently emerged as a novel regulator of cellular responses, the contribution of material dissipation to…
View article: A Geant4 tool for edge-illumination X-ray phase-contrast imaging
A Geant4 tool for edge-illumination X-ray phase-contrast imaging Open
The PEPI project is developing a new experimental facility integrating a chromatic photon-counting detector within an edge-illumination (EI) phase-contrast setup. In this context, a novel Geant4-based simulation tool has been introduced wi…
View article: Dual energy X-ray beam ptycho-fluorescence imaging
Dual energy X-ray beam ptycho-fluorescence imaging Open
X-ray ptychography and X-ray fluorescence are complementary nanoscale imaging techniques, providing structural and elemental information, respectively. Both methods acquire data by scanning a localized beam across the sample. X-ray ptychog…
View article: Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT
Motion artifacts assessment and correction using optical tracking in synchrotron radiation breast CT Open
Purpose The SYRMA‐3D collaboration is setting up a breast computed tomography (bCT) clinical program at the Elettra synchrotron radiation facility in Trieste, Italy. Unlike the few dedicated scanners available at hospitals, synchrotron rad…
View article: Pre- and post-reconstruction digital image processing solutions for computed tomography with spectral photon counting detectors
Pre- and post-reconstruction digital image processing solutions for computed tomography with spectral photon counting detectors Open
View article: 3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography
3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography Open
Characterizing nanoparticles (NPs) distribution in multiple and complex metastases is of fundamental relevance for the development of radiological protocols based on NPs administration. In the literature, there have been advances in monito…
View article: Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques
Chemo-physical properties of asbestos bodies in human lung tissues studied at the nano-scale by non-invasive, label free x-ray imaging and spectroscopic techniques Open
View article: Asbestos bodies count and morphometry in bulk lung tissue samples by non-invasive X-ray micro-tomography
Asbestos bodies count and morphometry in bulk lung tissue samples by non-invasive X-ray micro-tomography Open
View article: Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation
Steerable3D: An ImageJ plugin for neurovascular enhancement in 3-D segmentation Open
View article: Assessment of plaque morphology in Alzheimer’s mouse cerebellum using three-dimensional X-ray phase-based virtual histology
Assessment of plaque morphology in Alzheimer’s mouse cerebellum using three-dimensional X-ray phase-based virtual histology Open
View article: Edge-subtraction X-ray ptychographic imaging with pink beam synchrotron radiation and a single photon-counting detector
Edge-subtraction X-ray ptychographic imaging with pink beam synchrotron radiation and a single photon-counting detector Open
We present here a new method of performing X-ray edge-subtraction ptychographic imaging by combining multiple harmonics from an undulator synchtrotron source and an energy discriminating photon counting detector. Conventionally, monochroma…
View article: High resolution 3D visualization of the spinal cord in a post-mortem murine model
High resolution 3D visualization of the spinal cord in a post-mortem murine model Open
A crucial issue in the development of therapies to treat pathologies of the central nervous system is represented by the availability of non-invasive methods to study the three-dimensional morphology of spinal cord, with a resolution able …
View article: Single-shot K-edge subtraction x-ray discrete computed tomography with a polychromatic source and the Pixie-III detector
Single-shot K-edge subtraction x-ray discrete computed tomography with a polychromatic source and the Pixie-III detector Open
K-edge subtraction (KES) imaging is a technique able to map a specific element such as e.g. a contrast agent within the tissues, by exploiting the sharp rise of its absorption coefficient at the K-edge energy. Whereas mainly explored at sy…
View article: Issue Information
Issue Information Open