Francesco Brunetti
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View article: Gestational Diabetes Risk May Vary Depending on Birth Month
Gestational Diabetes Risk May Vary Depending on Birth Month Open
Background/Objectives: Prenatal environmental exposure may influence disease risk later in life. Previous studies suggest that season or month of birth affects susceptibility to various conditions, including type 2 diabetes. We aimed to ev…
View article: SUN-696 Thrombospondin-1 in Severe Obesity: a Hypoxia-Suppressed Cardiometabolic Biomarker Interacting with Endothelin-1
SUN-696 Thrombospondin-1 in Severe Obesity: a Hypoxia-Suppressed Cardiometabolic Biomarker Interacting with Endothelin-1 Open
Disclosure: M. Mirabelli: None. M. Greco: None. F.S. Brunetti: None. E. Chiefari: None. D.P. Foti: None. A. Brunetti: None. Background: Thrombospondin-1 (TSP1) is a multimeric glycoprotein mainly stored in platelet (PLT) granules but also …
View article: MON-568 HMGA1 Deficiency Ties Insulin Resistance to Tau-Related Neurodegeneration
MON-568 HMGA1 Deficiency Ties Insulin Resistance to Tau-Related Neurodegeneration Open
Disclosure: M. Mirabelli: None. F.S. Brunetti: None. E. Chiefari: None. D.P. Foti: None. A. Brunetti: None. Background: Growing evidence links tau-related neurodegeneration, a hallmark of Alzheimer's disease (AD) and other tauopathies, to …
View article: Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach
Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach Open
Background/Objectives: Systemic therapy with hedgehog pathway inhibitors (HHIs) and anti-programmed cell death protein 1 (PD-1) antibodies represent the first- and second-line treatment options for advanced basal cell carcinoma (aBCC), res…
View article: Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure
Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure Open
Summary Background Colorectal cancer (CRC) results from the accumulation of mutations and epigenetic changes in gut epithelial cells likely due to gut microbiota dysbiosis. However, limited research has been done to explore the link betwee…
View article: Concomitant or sequential radiotherapy and cemiplimab in advanced cutaneous squamous cell carcinoma: a multicenter real-life retrospective study
Concomitant or sequential radiotherapy and cemiplimab in advanced cutaneous squamous cell carcinoma: a multicenter real-life retrospective study Open
View article: Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women
Clinical Risk Factors and First Gestational 75 g OGTT May Predict Recurrent and New-Onset Gestational Diabetes in Multiparous Women Open
Background: Women who experience gestational diabetes mellitus (GDM) during their first pregnancy are at a high risk of developing GDM again in subsequent pregnancies. Even mothers with no previous history of GDM may develop the condition …
View article: Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding
Incidental thyroid carcinoma in an endemic goiter area in Italy: histopathological features and predictors of a common finding Open
View article: Coexistence of Hashimoto’s Thyroiditis in Differentiated Thyroid Cancer: Post-Operative Monitoring of Anti-Thyroglobulin Antibodies and Assessment of Treatment Response
Coexistence of Hashimoto’s Thyroiditis in Differentiated Thyroid Cancer: Post-Operative Monitoring of Anti-Thyroglobulin Antibodies and Assessment of Treatment Response Open
Introduction: Differentiated thyroid carcinoma (DTC) is frequently found in conjunction with autoimmune thyroid disorders, particularly Hashimoto’s thyroiditis (HT). This study investigates the impact of coexisting HT on the persistence of…
View article: Patient and Context Factors in the Adoption of Active Surveillance for Low-Risk Prostate Cancer
Patient and Context Factors in the Adoption of Active Surveillance for Low-Risk Prostate Cancer Open
Importance Although active surveillance for patients with low-risk prostate cancer (LRPC) has been recommended for years, its adoption at the population level is often limited. Objective To make active surveillance available for patients w…
View article: Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question
Metformin in Gestational Diabetes Mellitus: To Use or Not to Use, That Is the Question Open
In recent years, there has been a dramatic increase in the number of pregnancies complicated by gestational diabetes mellitus (GDM). GDM occurs when maternal insulin resistance develops and/or progresses during gestation, and it is not com…
View article: From Euglycemia to Recent Onset of Type 2 Diabetes Mellitus: A Proof-of-Concept Study on Circulating microRNA Profiling Reveals Distinct, and Early microRNA Signatures
From Euglycemia to Recent Onset of Type 2 Diabetes Mellitus: A Proof-of-Concept Study on Circulating microRNA Profiling Reveals Distinct, and Early microRNA Signatures Open
Background and aim—Alterations in circulating microRNA (miRNA) expression patterns are thought to be involved in the early stages of prediabetes, as well as in the progression to overt type 2 diabetes mellitus (T2D) and its vascular compli…
View article: Prothymosin-Alpha, a Novel and Sensitive Biomarker of the Inflammatory and Insulin-Resistant Statuses of Obese Individuals: A Pilot Study Involving Humans
Prothymosin-Alpha, a Novel and Sensitive Biomarker of the Inflammatory and Insulin-Resistant Statuses of Obese Individuals: A Pilot Study Involving Humans Open
Background: Obesity constitutes a chronic, low-grade inflammatory status that predisposes people to the development of insulin resistance and cardiometabolic complications. Hypoxia, a main pathological feature of visceral fat in obese indi…
View article: The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1
The anticancer effects of Metformin in the male germ tumor SEM-1 cell line are mediated by HMGA1 Open
Introduction Germ cell tumors (GCTs) are the most common type of cancer in young men. These tumors usually originate from the testis, but they can occasionally develop from extragonadal sites probably due to primordial germ cells (PGCs) mi…
View article: Human Colonic Microbiota and Short-Term Postoperative Outcomes in Colorectal Cancer Patients: A Pilot Study
Human Colonic Microbiota and Short-Term Postoperative Outcomes in Colorectal Cancer Patients: A Pilot Study Open
Despite the advances in surgical techniques and perioperative care, the complication rates after colorectal cancer surgery have remained stable. Recently, it has been suggested that colon microbiota may be implicated in several pathways th…
View article: 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy
2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy Open
View article: Endocrine Management of Transgender Adults: A Clinical Approach
Endocrine Management of Transgender Adults: A Clinical Approach Open
The attention to transgender medicine has changed over the last decade and the interest is most likely going to increase in the future due to the fact that gender-affirming treatments are now being requested by an increasing number of tran…
View article: Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives
Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives Open
Calcific Aortic Valve Disease (CAVD) is the most common valvular heart disease in developed countries and in the ageing population. It is strongly correlated to median age, affecting up to 13% of the population over the age of 65. Pathophy…
View article: French survey on a cohort of emergency general surgery modifications induced by lockdown of the SARS-CoV-2 pandemic
French survey on a cohort of emergency general surgery modifications induced by lockdown of the SARS-CoV-2 pandemic Open
View article: Malignancy Analyses of Thyroid Nodules in Patients Subjected to Surgery with Cytological- and Ultrasound-Based Risk Stratification Systems
Malignancy Analyses of Thyroid Nodules in Patients Subjected to Surgery with Cytological- and Ultrasound-Based Risk Stratification Systems Open
The fine needle aspiration (FNA) cytology is the gold standard for the preoperative diagnosis of thyroid cancer. However, up to 30% of FNA examinations yield nondiagnostic or indeterminate results and this complicates patient management. C…
View article: Virtual unenhanced imaging of the liver derived from 160-mm rapid-switching dual-energy CT (rsDECT): Comparison of the accuracy of attenuation values and solid liver lesion conspicuity with native unenhanced images
Virtual unenhanced imaging of the liver derived from 160-mm rapid-switching dual-energy CT (rsDECT): Comparison of the accuracy of attenuation values and solid liver lesion conspicuity with native unenhanced images Open
View article: Conversions related to adhesions in abdominal surgery. Robotic versus laparoscopic approach: A multicentre experience
Conversions related to adhesions in abdominal surgery. Robotic versus laparoscopic approach: A multicentre experience Open
Background An advantage of robotic surgery over laparoscopy is the lower rate of unplanned conversion. One of the implicated reasons for conversion is adhesions from previous abdominal surgeries (PASs). Methods A comparative analysis of 98…
View article: Advantages of robotic right colectomy over laparoscopic right colectomy beyond the learning curve: a systematic review and meta-analysis
Advantages of robotic right colectomy over laparoscopic right colectomy beyond the learning curve: a systematic review and meta-analysis Open
Background: With the widespread application of robotic systems and the increasing number of studies comparing robotic right colectomy (RRC) and laparoscopic right colectomy (LRC), there is a need for an up-to-date systemic review and meta-…
View article: PDE-5i Management of Erectile Dysfunction After Rectal Surgery: A Systematic Review Focusing on Treatment Efficacy
PDE-5i Management of Erectile Dysfunction After Rectal Surgery: A Systematic Review Focusing on Treatment Efficacy Open
Erectile dysfunction (ED) is one of the main functional complications of surgical resections of the rectum due to rectal cancers or inflammatory bowel disease (IBD). The present systematic review aimed at revising ED management strategies …
View article: MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy
MicroRNA-1281 as a Novel Circulating Biomarker in Patients With Diabetic Retinopathy Open
Objective: Recently, the role of circulating miRNAs as non-invasive biomarkers for the identification and monitoring of diabetes microvascular complications has emerged. Herein, we aimed to: identify circulating miRNAs differentiall…
View article: Surgery and COVID-19: Balancing the nosocomial risk a french academic center experience during the epidemic peak
Surgery and COVID-19: Balancing the nosocomial risk a french academic center experience during the epidemic peak Open
International audience
View article: Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance
Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance Open
View article: Predictors of mortality following emergency open colectomy for ischemic colitis: a single-center experience
Predictors of mortality following emergency open colectomy for ischemic colitis: a single-center experience Open
View article: Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases
Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases Open
Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide spectrum of pathological conditions, such as non-alcoh…
View article: Predicting Difficult Laparoscopic Total Mesorectal Excision for Locally-advanced Mid-low Rectal Cancer: The <i>EuMaRCS</i> Score Validation
Predicting Difficult Laparoscopic Total Mesorectal Excision for Locally-advanced Mid-low Rectal Cancer: The <i>EuMaRCS</i> Score Validation Open
The EuMaRCS score represents a validated tool to predict preoperatively difficult L-TME in LARC patients.