Francesco De Seta
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View article: The Relationship Between the Vaginal Microbiota and the Ovarian Cancer Microenvironment: A Journey from Ideas to Insights
The Relationship Between the Vaginal Microbiota and the Ovarian Cancer Microenvironment: A Journey from Ideas to Insights Open
Background: The tumor microenvironment offers a new perspective in gynecologic oncology. In ovarian cancer, numerous preclinical studies, especially organoid models, have highlighted cellular, immune, and biochemical mechanisms. Beyond the…
View article: New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections
New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections Open
Lower genital tract infections, particularly vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV), are among the most prevalent infections in women worldwide, especially those of reproductive age. These conditions not only cause sig…
View article: Cutibacterium acnes lysate improves cellular response against Candida albicans, Escherichia coli and Gardnerella vaginalis in an in vitro model of vaginal infection
Cutibacterium acnes lysate improves cellular response against Candida albicans, Escherichia coli and Gardnerella vaginalis in an in vitro model of vaginal infection Open
Introduction The vagina is a finely balanced microecological environment. The rupture of this balance leads to dysbiosis, which causes the resident microbiota to be overcome by pathogens. This event triggers the onset of gynecological infe…
View article: Probiotics in pregnancy and group B streptococcus colonization: A multicentric, randomized, placebo-controlled, double-blind study with a focus on vaginal microbioma
Probiotics in pregnancy and group B streptococcus colonization: A multicentric, randomized, placebo-controlled, double-blind study with a focus on vaginal microbioma Open
Although the clinical outcomes were unaffected, administration of probiotics led to favourable changes in vaginal microbiota. It remains to be established how this effect could be translated into clinical advantage.
View article: <i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age
<i>Lactobacillus iners</i> dominates the vaginal microbiota of healthy Italian women of reproductive age Open
Large sex hormonal fluctuations are thought to influence vaginal microbiota, but little is known about the impact of small, physiological variations. Here we tracked changes in vaginal microbiota during four key menstrual cycle phases in 6…
View article: Bacillus coagulans LMG S-24828 Impairs Candida Virulence and Protects Vaginal Epithelial Cells against Candida Infection In Vitro
Bacillus coagulans LMG S-24828 Impairs Candida Virulence and Protects Vaginal Epithelial Cells against Candida Infection In Vitro Open
Probiotics are living microbes that provide benefits to the host. The growing data on health promotion, following probiotics administration, increased interest among researchers and pharmaceutical companies. Infections of the lower genital…
View article: Sexually Transmitted Infections in Italian Young and Adult People: A Worrying Positive Trend Hidden by COVID-19 Epidemic
Sexually Transmitted Infections in Italian Young and Adult People: A Worrying Positive Trend Hidden by COVID-19 Epidemic Open
Recent European data show an increase in sexually transmitted infections (STIs), particularly N. gonorrhoeae, among young heterosexuals, surpassing pre-pandemic numbers. Italy’s varied local health restrictions during the COVID-19 pandemic…
View article: <i>Bacillus coagulans</i> LMG S-24828 Impairs <i>Candida</i> Virulence and Protects Vaginal Epithelial Cells against <i>Candida</i> Infection In Vitro
<i>Bacillus coagulans</i> LMG S-24828 Impairs <i>Candida</i> Virulence and Protects Vaginal Epithelial Cells against <i>Candida</i> Infection In Vitro Open
Probiotics are living microbes that provide benefits to the host. The increasing data on health promotion following probiotics administration triggered growing interest among researchers and pharmaceutical companies looking for novel thera…
View article: Fungal burden, dimorphic transition and candidalysin: Role in Candida albicans-induced vaginal cell damage and mitochondrial activation in vitro
Fungal burden, dimorphic transition and candidalysin: Role in Candida albicans-induced vaginal cell damage and mitochondrial activation in vitro Open
Candida albicans ( C . albicans ) can behave as a commensal yeast colonizing the vaginal mucosa, and in this condition is tolerated by the epithelium. When the epithelial tolerance breaks down, due to C . albicans overgrowth and hyphae for…
View article: Genital Dysbiosis and Different Systemic Immune Responses Based on the Trimester of Pregnancy in SARS-CoV-2 Infection
Genital Dysbiosis and Different Systemic Immune Responses Based on the Trimester of Pregnancy in SARS-CoV-2 Infection Open
Respiratory infections are common in pregnancy with conflicting evidence supporting their association with neonatal congenital anomalies, especially during the first trimester. We profiled cytokine and chemokine systemic responses in 242 p…
View article: An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus
An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus Open
Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity. Recently, we demonstrated that Cell-Free Supernat…
View article: The Women4Health cohort: a unique cohort to study women-specific mechanisms of cardio-metabolic regulation
The Women4Health cohort: a unique cohort to study women-specific mechanisms of cardio-metabolic regulation Open
Aims Epidemiological research has shown relevant differences between sexes in clinical manifestations, severity, and progression of cardiovascular and metabolic disorders. To date, the mechanisms underlying these differences remain unknown…
View article: An Untargeted Metabolomic Analysis of Lactobacillus (L.) rhamnosus, L. acidophilus, L. plantarum and L. reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus
An Untargeted Metabolomic Analysis of Lactobacillus (L.) rhamnosus, L. acidophilus, L. plantarum and L. reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus Open
Lactobacilli are considered an inexhaustible source of potentially bioactive substances; indeed, several products from their metabolism are known to have immunomodulatory and anti-inflammatory activity. Recently, we demonstrated that cell-…
View article: Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality
Silent spontaneous uterine rupture in a term pregnancy with extrusion of an intact amniotic sac and without maternal and neonatal morbidity and mortality Open
Background.Uterine rupture in pregnancy is a rare and catastrophic complication with a high incidence of fetal and maternal morbidity and mortality.Silent spontaneous uterine rupture without maternal or neonatal morbidity or mortality is v…
View article: Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein
Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein Open
Candida causes an estimated half-billion cases of vulvovaginal candidiasis (VVC) every year. VVC is most commonly caused by Candida albicans , which, in this setting, triggers nonprotective neutrophil infiltration, aggressive local inflamm…
View article: Innovative solutions for disease management
Innovative solutions for disease management Open
View article: Anti-Candida and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis
Anti-Candida and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis Open
Vaginal ecosystem is a unique environment where, in physiological conditions, lactobacilli dominate. However, pathogenic microbial species responsible for vaginitis and vaginosis can also harbor vaginal microbiota. To extend our previously…
View article: Anti-<em>Candida</em> and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis
Anti-<em>Candida</em> and Anti-Inflammatory Properties of a Vaginal Gel Formulation: Novel Data Concerning Vaginal Infection and Dysbiosis Open
Vaginal ecosystem is a unique environment where, in physiological conditions, lactobacilli dominate. However, also pathogenic microbial species, responsible of vaginitis and vaginosis, can harbor vaginal microbiota. To extend the data publ…
View article: A New Phenotype in <i>Candida</i> -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains
A New Phenotype in <i>Candida</i> -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains Open
Despite a high incidence of VVC, we still have a poor understanding of this female-specific disease whose negative impact on women’s quality of life has become a public health issue. It is not yet possible to determine by genotype or labor…
View article: The Bacterial DNA Profiling of Chorionic Villi and Amniotic Fluids Reveals Overlaps with Maternal Oral, Vaginal, and Gut Microbiomes
The Bacterial DNA Profiling of Chorionic Villi and Amniotic Fluids Reveals Overlaps with Maternal Oral, Vaginal, and Gut Microbiomes Open
The in utero microbiome hypothesis has been long debated. This hypothesis will change our comprehension of the pioneer human microbiome if proved correct. In 60 uncomplicated pregnancies, we profiled the microbiome of chorionic villi (CV) …
View article: New Topical Therapy for Provoked Vestibulodynia: Improvement of Psychological and Sexual Well-Being
New Topical Therapy for Provoked Vestibulodynia: Improvement of Psychological and Sexual Well-Being Open
Vulvodynia is a vulvar discomfort that occurs in the absence of any specific, clinically identifiable disorder. Few therapies have shown to be effective for the treatment of vulvodynia. In our recently published study, we tested a drug-fre…
View article: Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis
Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis Open
This systematic review and meta-analysis aimed to determine if probiotic supplementation in pregnancy reduced maternal Group B streptococcus (GBS) recto-vaginal colonization in pregnant women at 35–37 weeks of gestation. Electronic databas…
View article: Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion
Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion Open
Recurrent vulvovaginal candidosis (RVVC) is a chronic, difficult to treat vaginal infection, caused by Candida species, which affects women of all ages and ethnic and social background. A long-term prophylactic maintenance regimen with ant…
View article: Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System <i>In Vitro</i>
Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System <i>In Vitro</i> Open
The incidence of VVC by non- albicans Candida (NAC) species, such as C. parapsilosis , is increasing. Treatment failure is common in NAC-VVC because some species are resistant or poorly susceptible to the antifungal agents normally employe…
View article: Provoked Vestibulodynia and Topical Treatment: A New Option
Provoked Vestibulodynia and Topical Treatment: A New Option Open
Background: Provoked vestibulodynia is commonly associated with dyspareunia and affects 7% to 15% of women. This pathology has major implications on sexual function and quality of life, and several types of treatments are available for its…
View article: Ladylift® non-ablative laser technology for the treatment of menopausal vestibulodynia and genitourinary syndrome
Ladylift® non-ablative laser technology for the treatment of menopausal vestibulodynia and genitourinary syndrome Open
All the women tolerated the therapy well without any adverse effects. However, the beneficial effect tended to gradually decrease over time, suggesting the need to perform more therapy sessions.
View article: Rational development and evaluation of novel formulations for urinary health
Rational development and evaluation of novel formulations for urinary health Open
View article: The Vaginal Microbiome: III. The Vaginal Microbiome in Various Urogenital Disorders
The Vaginal Microbiome: III. The Vaginal Microbiome in Various Urogenital Disorders Open
Objective This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial …
View article: The Vaginal Microbiome: II. Vaginal Dysbiotic Conditions
The Vaginal Microbiome: II. Vaginal Dysbiotic Conditions Open
Objective This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial …
View article: The Vaginal Microbiome: IV. The Role of Vaginal Microbiome in Reproduction and in Gynecologic Cancers
The Vaginal Microbiome: IV. The Role of Vaginal Microbiome in Reproduction and in Gynecologic Cancers Open
Objective This series of articles, titled The Vaginal Microbiome (VMB), written on behalf of the International Society for the Study of Vulvovaginal Disease, aims to summarize the recent findings and understanding of the vaginal bacterial …