Francesco Faita
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View article: Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic Homeostasis
Localized FLASH Radiotherapy Reduces Long-Term Skin and Muscle Damage While Preserving Systemic Homeostasis Open
Radiotherapy (RT) is a cornerstone treatment for nearly 50% of cancer patients, but its curative potential and safe dosing are constrained by cumulative toxicity to surrounding healthy tissues. Delivering RT at ultra-high dose rates (FLASH…
View article: Comparison of two transient elastography (TE) systems for measuring liver stiffness in clinical practice
Comparison of two transient elastography (TE) systems for measuring liver stiffness in clinical practice Open
Inter-instrument variations of liver stiffness measure (LSM) by transient elastography might be problematic in clinical practice. LSMs provided by 2 different systems were compared in outpatients with chronic liver disease (CLD). In 777 co…
View article: Deep Learning Segmentation Techniques for Atherosclerotic Plaque on Ultrasound Imaging: A Systematic Review
Deep Learning Segmentation Techniques for Atherosclerotic Plaque on Ultrasound Imaging: A Systematic Review Open
Background: Atherosclerotic disease is the leading global cause of death, driven by progressive plaque accumulation in the arteries. Ultrasound (US) imaging, both conventional (CUS) and intravascular (IVUS), is crucial for the non-invasive…
View article: Radiomics Feature Extraction from Ultrasound B-Mode Images and Radio-Frequency Signals of the Carotid Arterial Wall: A Feasibility Study
Radiomics Feature Extraction from Ultrasound B-Mode Images and Radio-Frequency Signals of the Carotid Arterial Wall: A Feasibility Study Open
Background Carotid ultrasound is largely used to assess arterial aging. Radiomics (quantitative imaging feature analysis) applied on ultrasound may allow characterizing wall ultrastructure and arterial ageing. However, to date its applicat…
View article: Sustainability of General Population Screening for Steatotic Liver Disease: A Proof-of-Concept Study
Sustainability of General Population Screening for Steatotic Liver Disease: A Proof-of-Concept Study Open
Background: Steatotic liver disease (SLD) is a growing global health concern and may progress to more advanced liver diseases (i.e., fibrosis, cirrhosis, and hepatocellular carcinoma). Early identification of individuals at risk through ef…
View article: Wearable Ultrasound: Are We Ready to Take This Chance for Vascular Ageing Assessment?
Wearable Ultrasound: Are We Ready to Take This Chance for Vascular Ageing Assessment? Open
Background Wearable ultrasound (US) is an emerging innovative approach with a possibly huge impact on personalized medicine. Recent advancements in transducer material and architecture provide new opportunities in many medical areas. Withi…
View article: Radiomics feature extraction from ultrasound B-mode images and radiofrequency signals of the carotid arterial wall: a feasibility study
Radiomics feature extraction from ultrasound B-mode images and radiofrequency signals of the carotid arterial wall: a feasibility study Open
Background: Carotid ultrasound is largely used to assess arterial aging. Radiomics applied on ultrasound may allow characterizing wall ultrastructure and arterial aging, however to date its application to the intima-media complex is unexpl…
View article: An ultrasound multiparametric method to quantify liver fat using magnetic resonance as standard reference
An ultrasound multiparametric method to quantify liver fat using magnetic resonance as standard reference Open
Background & Aims There is an unmet need for a reliable and reproducible non‐invasive measure of fatty liver content (FLC) for monitoring steatotic liver disease in clinical practice. Sonographic FLC assessment is qualitative and operator‐…
View article: Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction
Effects of sacubitril-valsartan on remodelling, fibrosis and mitochondria in a murine model of isoproterenol-induced left ventricular dysfunction Open
In a murine model of non-ischaemic HF, sacubitril/valsartan proved to have beneficial effects on LV systolic function, and on cardiac energetics, by improving mitochondrial activity.
View article: Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice
Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice Open
Background Dietary fat consumption, involved in the pathogenesis of insulin resistance and impaired glucose metabolism, is linked with decline in cognitive functions, dementia, and development of Parkinson’s disease and Alzheimer’s disease…
View article: Clustering of vascular aging manifestations and incident cardiovascular events. The Paris Prospective Study III
Clustering of vascular aging manifestations and incident cardiovascular events. The Paris Prospective Study III Open
Background Vascular aging is a key contributor to cardiovascular disease (CVD). Manifestations of vascular aging are heterogeneous and include atherosclerosis, arterial stiffening, increased arterial wall stress and arterial diameter enlar…
View article: Applications of Deep Learning Algorithms to Ultrasound Imaging Analysis in Preclinical Studies on In Vivo Animals
Applications of Deep Learning Algorithms to Ultrasound Imaging Analysis in Preclinical Studies on In Vivo Animals Open
Background and Aim: Ultrasound (US) imaging is increasingly preferred over other more invasive modalities in preclinical studies using animal models. However, this technique has some limitations, mainly related to operator dependence. To o…
View article: Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats
Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats Open
Background Exosomes (EXOs), tiny extracellular vesicles that facilitate cell–cell communication, are being explored as a heart failure treatment, although the features of the cell source restrict their efficacy. Fibroblasts the most preval…
View article: Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up
Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up Open
No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The ‘Train the Brain’ programme is a combined motor and cognitive…
View article: The impact of ventricular-arterial coupling on aerobic capacity across the heart failure spectrum
The impact of ventricular-arterial coupling on aerobic capacity across the heart failure spectrum Open
Background Ventricular-arterial coupling (VAC) can be evaluated as the ratio between arterial stiffness (pulse wave velocity, PWV) and myocardial deformation (global longitudinal strain, GLS). Objectives To evaluate VAC across the spectrum…
View article: Ultrasound Elastography in Inflammatory Bowel Diseases: A Systematic Review of Accuracy Compared with Histopathological Assessment
Ultrasound Elastography in Inflammatory Bowel Diseases: A Systematic Review of Accuracy Compared with Histopathological Assessment Open
Background and Aims Ultrasound elastography [USE] is an innovative, non-invasive, promptly available, ancillary technique that has been proposed in the evaluation of intestinal fibrosis as a monitorable biomarker, in terms of stiffness. Th…
View article: A causal learning framework for the analysis and interpretation of COVID-19 clinical data
A causal learning framework for the analysis and interpretation of COVID-19 clinical data Open
We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process …
View article: Applications of artificial intelligence in lung ultrasound: Review of deep learning methods for COVID-19 fighting
Applications of artificial intelligence in lung ultrasound: Review of deep learning methods for COVID-19 fighting Open
BACKGROUNDThe pandemic outbreak of the novel coronavirus disease (COVID-19) has highlighted the need to combine rapid, non-invasive and widely accessible techniques with the least risk of patient's cross-infection to achieve a successful e…
View article: A New SteatoScore in the Evaluation of Non-Alcoholic Liver Disease in Oncologic Patients
A New SteatoScore in the Evaluation of Non-Alcoholic Liver Disease in Oncologic Patients Open
Purpose The aims of this study were to evaluate the reproducibility of a new multi-parametric steatoscore (new SteatoScore) in oncologic patients with non-alcoholic fatty liver disease (NAFLD) and to compare it with computed tomography (CT…
View article: P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet
P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet Open
These findings seem to suggest a cardioprotective role of P2X7R toward this tissue-specific inflammatory damage, likely through tissue homeostasis and organ functionality preservation.
View article: Effects of Different Scan Projections on the Quantitative Ultrasound-Based Evaluation of Hepatic Steatosis
Effects of Different Scan Projections on the Quantitative Ultrasound-Based Evaluation of Hepatic Steatosis Open
Non-alcoholic fatty liver disease (NAFLD) is becoming a global public health issue and the identification of the steatosis severity is very important for the patients’ health. Ultrasound (US) images of 214 patients were acquired in two dif…
View article: 581 Ventricular–arterial coupling derived from proximal aortic stiffness and aerobic capacity across the heart failure spectrum
581 Ventricular–arterial coupling derived from proximal aortic stiffness and aerobic capacity across the heart failure spectrum Open
Aims Ventricular–arterial coupling (VAC) can be evaluated as the ratio between arterial stiffness (pulse wave velocity, PWV) and myocardial deformation (global longitudinal strain, GLS). To evaluate VAC across the spectrum of heart failure…
View article: A causal learning framework for the analysis and interpretation of COVID-19 clinical data
A causal learning framework for the analysis and interpretation of COVID-19 clinical data Open
We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process …