Francesco Giuseppe De Rosa
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View article: Diphtheria-like Pseudomembranous Corynebacterium striatum Chronic Infection of Left Ventricular Assist Device Driveline Bridged to Heart Transplantation with Dalbavancin Treatment
Diphtheria-like Pseudomembranous Corynebacterium striatum Chronic Infection of Left Ventricular Assist Device Driveline Bridged to Heart Transplantation with Dalbavancin Treatment Open
Background and Clinical Significance: Corynebacterium striatum is an emerging multidrug-resistant pathogen increasingly implicated in infections among immunocompromised patients and patients with indwelling medical devices. Case Presentati…
View article: Cefiderocol therapy among immunocompromised adult patients: a descriptive analysis from a prospective, multicentre cohort study
Cefiderocol therapy among immunocompromised adult patients: a descriptive analysis from a prospective, multicentre cohort study Open
View article: Medical source control with oritavancin in complicated gram-positive bacterial infections: A case series
Medical source control with oritavancin in complicated gram-positive bacterial infections: A case series Open
View article: Vascular Graft Infections Due to Listeria spp.: A Comprehensive Review of the Literature
Vascular Graft Infections Due to Listeria spp.: A Comprehensive Review of the Literature Open
Vascular graft infections are rare but serious complications of vascular surgery. Listeria monocytogenes represents an exceedingly rare yet potentially life-threatening cause. We present a narrative review according to the Scale for the As…
View article: Cutaneous and Lymphangitic Infection Caused by Purpureocillium lilacinum in Immunocompromised Patients: A Case Report with a Narrative Review of the Literature
Cutaneous and Lymphangitic Infection Caused by Purpureocillium lilacinum in Immunocompromised Patients: A Case Report with a Narrative Review of the Literature Open
Background: Purpureocillium lilacinum (P. lilacinum) is an emerging filamentous fungus known to cause opportunistic infections, particularly in immunocompromised patients. Formerly known as Paecilomyces lilacinus, this pathogen is widespre…
View article: The Role of Microbiology at the 1-Month Surveillance Bronchoalveolar Lavage in the Identification of Complications in the First Year After Lung-Transplantation—A Retrospective Single-Center Experience
The Role of Microbiology at the 1-Month Surveillance Bronchoalveolar Lavage in the Identification of Complications in the First Year After Lung-Transplantation—A Retrospective Single-Center Experience Open
Acute rejection and infections are the most frequent complications in the first year after lung transplantation, often representing relevant causes of death. There is still no consensus on the ideal strategy for preventing these events, wi…
View article: Micronutrient status and fatty acid profile of adults with SARS-CoV-2 infection—an observational study
Micronutrient status and fatty acid profile of adults with SARS-CoV-2 infection—an observational study Open
Introduction SARS-CoV-2 infection is a complex disease with multiple dimensions, involving factors that promote infection and virus-driven processes in many body organs. The micronutrient status, beyond others, acts as a potential confound…
View article: Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study
Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study Open
Objectives In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes. Methods Prospective, obs…
View article: Clinical Impact of New Delhi Metallo-Beta-Lactamase-Producing Enterobacterales in Critically Ill Patients: Are We Ready to Face the Challenge?
Clinical Impact of New Delhi Metallo-Beta-Lactamase-Producing Enterobacterales in Critically Ill Patients: Are We Ready to Face the Challenge? Open
Background: Carbapenem-resistant Enterobacterales infections are frequent in critically ill patients. Outbreaks caused by carbapenemase-producing Enterobacterales, in particular the New Delhi Metallo-beta-lactamase (NDM)-type carbapenemase…
View article: Bloodstream infections epidemiology and clinical outcomes after 1 year post allogeneic hematogenous stem cell transplantation
Bloodstream infections epidemiology and clinical outcomes after 1 year post allogeneic hematogenous stem cell transplantation Open
Background Bloodstream infections (BSIs) are a serious threat for patients undergoing allogenic hematopoietic stem cell transplants (a-HSCT). MDR colonization is highly prevalent among a-HSCT patients, due to drug-induced intestinal dysbio…
View article: Impact of RSV Infection in Transplant and Immunocompromised Population: Incidence and Co-Infections: Retrospective Analysis of a Single Centre
Impact of RSV Infection in Transplant and Immunocompromised Population: Incidence and Co-Infections: Retrospective Analysis of a Single Centre Open
Respiratory syncytial virus (RSV) represents one of the main respiratory infections found among immunocompromised patients. Objective: The study analyzes the incidence of RSV infection in different populations of immunocompromised patients…
View article: Context-aware data augmentation for enhanced speech command recognition in industrial environments
Context-aware data augmentation for enhanced speech command recognition in industrial environments Open
In Human-Robot Interaction, speech is one of the most intuitive and effective communication channel. In Industry 4.0, speech-based communication can significantly enhance productivity and efficiency on production lines. However, deploying …
View article: Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study
Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study Open
Introduction This large, multicenter, Italian retrospective study aimed to describe clinical characteristics and risk factors associated with 30-day mortality in patients with Pseudomonas aeruginosa bloodstream infections (PA-BSI) admitted…
View article: Hypothermic oxygenated machine perfusion does not increase the risk of infection after liver transplantation: a retrospective cohort study
Hypothermic oxygenated machine perfusion does not increase the risk of infection after liver transplantation: a retrospective cohort study Open
The study results indicate that HOPE use in LT does not increase the risk of infection and is associated with similar patient and graft survival outcomes compared to SCS. These findings confirm the safety and efficacy of HOPE in LT and its…
View article: Role of liposomal amphotericin B in intensive care unit: an expert opinion paper
Role of liposomal amphotericin B in intensive care unit: an expert opinion paper Open
Introduction Invasive fungal infections (IFI) are frequent in patients admitted to the intensive care unit (ICU). The use of first-line antifungals like triazoles or echinocandins may be limited by the global spread of multi-drug resistanc…
View article: The Epidemiology of Respiratory Syncytial Virus and the Impact of the COVID-19 Pandemic in a Retrospective Evaluation
The Epidemiology of Respiratory Syncytial Virus and the Impact of the COVID-19 Pandemic in a Retrospective Evaluation Open
Introduction: Respiratory syncytial virus (RSV) is the main etiological agent in pediatric lower respiratory tract infections. The limited availability of therapeutic options for severe clinical cases associated with RSV infection makes pr…
View article: Quality indicators for appropriate inpatient antibiotic use: results from two national surveys in Italy, 2016–2022
Quality indicators for appropriate inpatient antibiotic use: results from two national surveys in Italy, 2016–2022 Open
This study provided a mapping of prescribing activity at national level, and defined measurable quality indicators, through which strengths and areas for improvement in prescribing practices were identified.
View article: Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study
Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study Open
View article: Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review
Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review Open
View article: HHV-6 reactivations in immunocompetent patients with psychiatric disorders: visual hallucinations or possible interactions?
HHV-6 reactivations in immunocompetent patients with psychiatric disorders: visual hallucinations or possible interactions? Open
View article: UHPLC-MS/MS method for the simultaneous quantification of five calcium channel antagonists’ drugs in human plasma
UHPLC-MS/MS method for the simultaneous quantification of five calcium channel antagonists’ drugs in human plasma Open
One of the principal challenges in managing hypertension is suboptimal medication adherence, which can result in up to 50 % of patients experiencing pseudo-resistant hypertension and inadequate blood pressure control. The intricate nature …
View article: Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences
Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences Open
Ceftobiprole represents a valid option for the patients with CAP and HAP. Its main advantages include its broad spectrum of activity, making it a valuable therapeutic choice for treating polymicrobial infections, and its favorable safety p…
View article: Impact of Multidrug-Resistant Bacteria in a Cohort of COVID-19 Critically Ill Patients: Data from a Prospective Observational Study Conducted in a High-Antimicrobial-Resistance-Prevalence Center
Impact of Multidrug-Resistant Bacteria in a Cohort of COVID-19 Critically Ill Patients: Data from a Prospective Observational Study Conducted in a High-Antimicrobial-Resistance-Prevalence Center Open
Background: Bacterial superinfections are common complications during viral infections, but the impact of multidrug-resistant (MDR) pathogens in critically ill patients affected by coronavirus disease 2019 (COVID-19) is still debated. Meth…
View article: Influence of ESBL colonization status on gut microbiota composition during allogenic hematopoietic stem cell transplantation
Influence of ESBL colonization status on gut microbiota composition during allogenic hematopoietic stem cell transplantation Open
View article: Transformations of crude oil into tar: a case study from a plastitar-contaminated site in NE Sicily, Italy (Western Mediterranean)
Transformations of crude oil into tar: a case study from a plastitar-contaminated site in NE Sicily, Italy (Western Mediterranean) Open
This study examines the aging of industrial crude oil to simulate the chemical transformations that occur when it is exposed to environmental conditions over time. It was triggered by the finding of plastitar - a mixture of tar and plastic…
View article: Diagnostic and prognostic value of time to positivity in blood cultures. An opinion paper
Diagnostic and prognostic value of time to positivity in blood cultures. An opinion paper Open
Time to positivity (TTP) refers to the duration required for a microbiological culture test to indicate a positive result, marking the onset of detectable bacterial or fungal growth in the sample. Numerous variables, including patient char…
View article: Effectiveness, Safety, and Patterns of Real-World Isavuconazole Use in Europe (2015–2019)
Effectiveness, Safety, and Patterns of Real-World Isavuconazole Use in Europe (2015–2019) Open
This study adds to the growing body of evidence that whether used as first-line therapy or after the failure of other antifungal therapies, isavuconazole appears to have a promising clinical response and a good safety profile as an antifun…
View article: Orbital Myositis after Herpes Zoster Ophthalmicus: A Case Report and a Narrative Review of the Literature
Orbital Myositis after Herpes Zoster Ophthalmicus: A Case Report and a Narrative Review of the Literature Open
Herpes zoster ophthalmicus results from the reactivation of the latent varicella zoster virus, affecting the first branch of the trigeminal nerve. In 20–70% of cases, Zoster Ophthalmicus can lead to ocular involvement, affecting various or…
View article: Plastic pellet pollution in the Aeolian Islands UNESCO site (Italy, Western Mediterranean Sea): results of a comprehensive characterization and monitoring study
Plastic pellet pollution in the Aeolian Islands UNESCO site (Italy, Western Mediterranean Sea): results of a comprehensive characterization and monitoring study Open
The archipelago of the Aeolian Islands in the Tyrrhenian Sea is a globally important natural laboratory. The archipelago, declared a UNESCO World Heritage Site for its unique geology and biodiversity, offers a unique opportunity to study p…
View article: Risk factors for mortality in Acinetobacter baumannii bloodstream infections and development of a predictive mortality model
Risk factors for mortality in Acinetobacter baumannii bloodstream infections and development of a predictive mortality model Open
A. baumannii BSIs are characterized by poor outcomes and limited therapeutic options. This study aimed to assist physicians in prompt identification of patients who are at greater risk of death, contributing to more informed clinical decis…