Francesco Nicoli
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View article: Perceptions on vaccines, vaccine communication and information needs of healthcare professionals involved in older adult vaccination: A cross-country interview study
Perceptions on vaccines, vaccine communication and information needs of healthcare professionals involved in older adult vaccination: A cross-country interview study Open
The global population of older adults is growing. Older adults are more vulnerable to infectious diseases compared to younger adults. Vaccines are available to protect older adults against several infectious diseases, yet their uptake rema…
View article: Rutin-containing cyclodextrin nanosystems: a possible strategy for dietary supplementation in diabetics
Rutin-containing cyclodextrin nanosystems: a possible strategy for dietary supplementation in diabetics Open
The flavonoid rutin is an active ingredient with multiple health benefits featuring antioxidant, anti-inflammatory, cardiovascular, neuroprotective, anti-diabetic and anti-tumor activity, unfortunately characterized by physico-chemical ins…
View article: Aging and inflammation limit the induction of SARS-CoV-2–specific CD8+ T cell responses in severe COVID-19
Aging and inflammation limit the induction of SARS-CoV-2–specific CD8+ T cell responses in severe COVID-19 Open
CD8+ T cells are critical for immune protection against severe COVID-19 during acute infection with SARS-CoV-2. However, the induction of antiviral CD8+ T cell responses varies substantially among infected people, and a better understandin…
View article: Synthesis and Evaluation of a ZnO-Chitosan Adduct for Safe and Sustainable Enhanced Ultra-Violet (UV) Sunscreens Protection
Synthesis and Evaluation of a ZnO-Chitosan Adduct for Safe and Sustainable Enhanced Ultra-Violet (UV) Sunscreens Protection Open
Chitosan (Ch), a natural polysaccharide, is known for its biocompatibility, biodegradability, and various beneficial properties, including antioxidant and antibacterial activities. The objective of this study is to investigate the function…
View article: Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 Open
Adenoviral and mRNA vaccines encoding the viral spike (S) protein have been deployed globally to contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Older individuals are particularly vulnerable to severe infection, proba…
View article: Development of an Oral IgA Response against SARS-CoV-2 Following Immunization with Different COVID-19 Vaccines
Development of an Oral IgA Response against SARS-CoV-2 Following Immunization with Different COVID-19 Vaccines Open
The mucosal immune response is recognized to be important in the early control of infection sustained by viruses with mucosal tissues as the primary site of entry and replication, such as SARS-CoV-2. Mucosal IgA has been consistently repor…
View article: Information networks of healthcare professionals in Europe on older adult vaccines: Network analysis
Information networks of healthcare professionals in Europe on older adult vaccines: Network analysis Open
Background and objectives Healthcare professionals (HCP) have a key role in raising awareness and informing older adult patients about vaccines. However, HCPs are sometimes unaware of existing vaccines or have little knowledge on them. Thi…
View article: Age differentially affects the maintenance of adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19
Age differentially affects the maintenance of adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 Open
Adenoviral and mRNA vaccines encoding the viral spike protein have been deployed globally to contain SARS-CoV-2. Elderly individuals are particularly vulnerable to severe infection, likely reflecting age-related changes in the immune syste…
View article: Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 Open
Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated in vitro approach t…
View article: Effects of Sirolimus treatment on patients with <scp>β‐Thalassemia</scp>: Lymphocyte immunophenotype and biological activity of memory <scp>CD4</scp><sup>+</sup> and <scp>CD8</scp><sup>+</sup> T cells
Effects of Sirolimus treatment on patients with <span>β‐Thalassemia</span>: Lymphocyte immunophenotype and biological activity of memory <span>CD4</span><sup>+</sup> and <span>CD8</span><sup>+</sup> T cells Open
Inhibitors of the mammalian target of rapamycin (mTOR) have been proposed to improve vaccine responses, especially in the elderly. Accordingly, testing mTOR inhibitors (such as Sirolimus) and other geroprotective drugs might be considered …
View article: Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents
Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents Open
A current trend of research in the health field is toward the discovery of multifunctional compounds, capable of interacting with multiple biological targets, thus simplifying multidrug therapies and improving patient compliance. The aim o…
View article: PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment Open
View article: Vaccines for older adults; the low-hanging fruit of disease prevention
Vaccines for older adults; the low-hanging fruit of disease prevention Open
Background The COVID-19 pandemic highlighted the significance of vaccination for older adults (OA), however, more health benefits could be gained with vaccination against influenza, pneumococcal disease, herpes zoster and tetanus as their …
View article: Why Restricting Tourist Visas to Russians is Legitimate
Why Restricting Tourist Visas to Russians is Legitimate Open
In the aftermath of Ukrainian President Zelenski’s call on the EU to introduce a ban on short-term ‘tourist’ visas for Russians wishing to travel the Schengen area, a lively debate on the issue erupted, featuring important interventions no…
View article: Effects of the age of vaccination on the humoral responses to a human papillomavirus vaccine
Effects of the age of vaccination on the humoral responses to a human papillomavirus vaccine Open
View article: Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination
Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination Open
The severity of bacterial and viral infections is linked to impaired immune and metabolic disorders,
\ndisproportionally affecting individuals with metabolic comorbidities such as obesity, type 2 diabetes,
\nand cardiovascular diseases. Th…
View article: Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old
Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old Open
View article: Possible effects of sirolimus treatment on the long‑term efficacy of COVID‑19 vaccination in patients with β‑thalassemia: A theoretical perspective
Possible effects of sirolimus treatment on the long‑term efficacy of COVID‑19 vaccination in patients with β‑thalassemia: A theoretical perspective Open
The pandemic caused by the severe acute respiratory syndrome coronavirus (SARS‑CoV‑2), responsible for coronavirus disease 2019 (COVID‑19) has posed a major challenge for global health. In order to successfully combat SARS‑CoV‑2, the devel…
View article: Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans
Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8+ T Cells in Elderly Humans Open
Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless r…
View article: Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania
Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania Open
People living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles a…
View article: Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects Open
Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8 + T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity ma…
View article: Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines Open
Peptide vaccines incorporating B- and T-cell epitopes have shown promise in the context of various cancers and infections. These vaccines are relatively simple to manufacture, but more immunogenic formulations are considered a priority. We…
View article: Old and new coronaviruses in the elderly
Old and new coronaviruses in the elderly Open
View article: Altered basal lipid metabolism underlies the functional impairment of naive CD8<sup>+</sup>T cells in elderly humans
Altered basal lipid metabolism underlies the functional impairment of naive CD8<sup>+</sup>T cells in elderly humans Open
Background Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered antigens. The mechanisms that underlie this phenomenon ha…
View article: Information needs on vaccinations for older adults and the role of health care professionals in this
Information needs on vaccinations for older adults and the role of health care professionals in this Open
On behalf of all members of work package 4 from the VITAL project
View article: The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro
The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro Open
View article: Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity
Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity Open
View article: The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation Open
The development of therapeutic strategies to control the reactivation of the Herpes Simplex Virus (HSV) is an unaddressed priority. In this study, we evaluated whether Tat, a HIV-1 protein displaying adjuvant functions, could improve previ…
View article: Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells
Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells Open
Human IgA could be from different isotypes (IgA1/IgA2) and/or isoforms (monomeric, dimeric, or secretory). Monomeric IgA mainly IgA1 are considered as an anti‐inflammatory isotype whereas dimeric/secretory IgA have clearly dual pro‐ and an…
View article: Author response for "Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells"
Author response for "Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells" Open