Francesco Paolo Pilato
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View article: CD26 Is Differentially Expressed throughout the Life Cycle of Infantile Hemangiomas and Characterizes the Proliferative Phase
CD26 Is Differentially Expressed throughout the Life Cycle of Infantile Hemangiomas and Characterizes the Proliferative Phase Open
Infantile hemangiomas (IHs) are benign vascular neoplasms of childhood (prevalence 5–10%) due to the abnormal proliferation of endothelial cells. IHs are characterized by a peculiar natural life cycle enclosing three phases: proliferative …
View article: Testicular metastasis of prostate adenocarcinoma: the other side of orchiepididymitis
Testicular metastasis of prostate adenocarcinoma: the other side of orchiepididymitis Open
Although metastatic prostate adenocarcinoma is rare, a correct diagnosis is of paramount importance because the therapy changes accordingly. Patients who complain of scrotal pain need to be examined accurately. Although the most common cau…
View article: Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity
Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity Open
Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistance. This study aimed to assess the inter-tum…
View article: Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro
Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro Open
Our data suggest that autophagy may be ascribed among the mechanisms of action of β-blockers suggesting new mechanistic insights on the potential therapeutic application of this class of drugs in pathologic conditions involving uncontrolle…
View article: P1832IGG4 RELATED DISEASE: NEPHROPATHY AND BONE MARROW FAILURE IN A 2 YEAR-OLD CHILD
P1832IGG4 RELATED DISEASE: NEPHROPATHY AND BONE MARROW FAILURE IN A 2 YEAR-OLD CHILD Open
Background and Aims IgG4 related disease (IgG4 RD) is a recently recognized systemic immune-mediated disorder. Pathophysiology of the disease is still unclear. It is characterized by fibro-inflammatory damage of the tissues, IgG-4 positive…
View article: Immune Context Characterization and Heterogeneity in Primary Tumors and Pulmonary Metastases from Renal Cell Carcinoma
Immune Context Characterization and Heterogeneity in Primary Tumors and Pulmonary Metastases from Renal Cell Carcinoma Open
The immune context of RCC is highly variable both within a given tumor and among primary and metastases.
View article: Giant bilateral renal metastases from a meningeal hemangiopericytoma
Giant bilateral renal metastases from a meningeal hemangiopericytoma Open
We report the third case of bilateral metastatic renal meningeal hemangiopericytoma (HPC) 16 years after initial intracranial presentation. A 47-year-old male patient presented with abdominal mass drew our attention. Computed tomography (C…