Francesco Pisani
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View article: Scalp high‐frequency activity differentiates neonates with seizures from healthy neonates and indicates postneonatal epilepsy risk
Scalp high‐frequency activity differentiates neonates with seizures from healthy neonates and indicates postneonatal epilepsy risk Open
Objective This study investigated whether scalp high‐frequency activity (HFA) rates in neonates with seizures predict postneonatal epilepsy (PNE). It also assessed whether HFA rates differentiate neonates with seizures from healthy neonate…
View article: Effects of Pilates Matwork Core Exercises on Functioning in Middle-Aged Adult Women with Chronic Nonspecific Low Back Pain Through Flexion Relaxation Phenomenon Analysis: A Pilot RCT
Effects of Pilates Matwork Core Exercises on Functioning in Middle-Aged Adult Women with Chronic Nonspecific Low Back Pain Through Flexion Relaxation Phenomenon Analysis: A Pilot RCT Open
Objectives: Pilates is frequently recommended for patients with Chronic Nonspecific Low Back Pain (CNLBP) due to its potential to enhance posture, muscle strength, trunk flexibility, and stability. However, to date, there is no robust evid…
View article: Impact, strategies and performance profiles related to the rackets in padel players: a scoping review
Impact, strategies and performance profiles related to the rackets in padel players: a scoping review Open
View article: Kidney Transplant Surgery
Kidney Transplant Surgery Open
View article: Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy
Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy Open
Multiple myeloma (MM) continues to be an incurable malignancy, even with recent therapeutic advancements. While epigenetic dysregulation at cis-regulatory elements is known to drive disease progression, the complete molecular mechanisms un…
View article: The value of CSF neurotransmitter monitoring in the outcome of gene therapy in aromatic amino acid decarboxylase (AADC) defect
The value of CSF neurotransmitter monitoring in the outcome of gene therapy in aromatic amino acid decarboxylase (AADC) defect Open
View article: Clinicians’ Perspectives and Methodological Application of Fluorescence in situ Hybridization (FISH) to Define Cytogenetic Risk in Multiple Myeloma: An Italian, Real-World, Survey-Based Report From the European Myeloma Network (EMN) Italy
Clinicians’ Perspectives and Methodological Application of Fluorescence in situ Hybridization (FISH) to Define Cytogenetic Risk in Multiple Myeloma: An Italian, Real-World, Survey-Based Report From the European Myeloma Network (EMN) Italy Open
View article: Novel Methods for the Analysis of Serum NET Remnants: Evaluation in Patients with Severe COVID-19
Novel Methods for the Analysis of Serum NET Remnants: Evaluation in Patients with Severe COVID-19 Open
Neutrophil extracellular traps (NETs) are web-like structures composed of chromatin and proteins from neutrophil granules. Several studies highlight the heterogeneity of NETs, underscoring the challenges associated with their detection. In…
View article: Mechanical Focal Vibration Therapy for Muscle Injury Recovery in a Runner
Mechanical Focal Vibration Therapy for Muscle Injury Recovery in a Runner Open
Vibrotherapy has been gaining popularity as a conceivable rehabilitative physical agent modality to decrease the pain and time for proper return-to-sport. This study aimed to assess the administration of mechanical Focal Vibration (mFV) in…
View article: Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results
Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results Open
PURPOSE The role of consolidation radiotherapy in patients with primary mediastinal B-cell lymphoma (PMBCL) is controversial. METHODS The IELSG37 trial, a randomized noninferiority study, aimed to assess whether irradiation can be omitted …
View article: The diagnostic and prognostic role of cerebrospinal fluid biomarkers in glucose transporter 1 deficiency: a systematic review
The diagnostic and prognostic role of cerebrospinal fluid biomarkers in glucose transporter 1 deficiency: a systematic review Open
The purpose of this study is to investigate the diagnostic and prognostic role of cerebrospinal fluid (CSF) biomarkers in the diagnostic work-up of glucose transporter 1 (GLUT1) deficiency. Reported here is a systematic review according to…
View article: Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells
Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells Open
View article: The influence of wakefulness fluctuations on brain networks involved in centrotemporal spike occurrence
The influence of wakefulness fluctuations on brain networks involved in centrotemporal spike occurrence Open
View article: Mast cell signaling and its role in urticaria
Mast cell signaling and its role in urticaria Open
Chronic urticaria is a mast cell (MC)-driven disease characterized by the development of itching wheals and/or angioedema. In the last decades, outstanding progress has been made in defining the mechanisms involved in MC activation, and no…
View article: Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim
Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim Open
Data about biosimilar Peg-filgrastim (bioPEG) in autologous stem cell transplant (ASCT) are still scarce. The aim of this study has been to assess efficacy and safety of bioPEG among lymphoma and myeloma patients undergoing ASCT, comparing…
View article: IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma
IELSG30 phase 2 trial: intravenous and intrathecal CNS prophylaxis in primary testicular diffuse large B-cell lymphoma Open
Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by high risk of contralateral testis and central nervous system (CNS) relapse. Chemoimmunotherapy with intrathecal (IT) CNS prophylaxis and contralateral testis irradi…
View article: ‘A novel <i>TRIP4</i> Variant Associated with Peripheral Neuropathy: Expanding the Clinical and Genetic Spectrum of ASC1-Related Myopathy’
‘A novel <i>TRIP4</i> Variant Associated with Peripheral Neuropathy: Expanding the Clinical and Genetic Spectrum of ASC1-Related Myopathy’ Open
Activating Signal Cointegrator 1 complex (ASC-1 complex) is a ribonucleoprotein tetramer participating in transcriptional coactivation and RNA processing, consisting of four subunits: ASCC1-ASCC3 and ASC-1. Pathogenic variants in the TRIP4…
View article: Refinement of MRD Assessment in Hairy Cell Leukemia by Integrated Molecular and Flow Cytometry Analysis
Refinement of MRD Assessment in Hairy Cell Leukemia by Integrated Molecular and Flow Cytometry Analysis Open
View article: The Microvascular Health Status Predicts Radio-Induced Acute Toxicities in Breast, Prostate and Head and Neck Cancer Patients
The Microvascular Health Status Predicts Radio-Induced Acute Toxicities in Breast, Prostate and Head and Neck Cancer Patients Open
View article: Reassessment of the NF1 variants of unknown significance found during the 20-year activity of a genetics diagnostic laboratory
Reassessment of the NF1 variants of unknown significance found during the 20-year activity of a genetics diagnostic laboratory Open
The finding of variants of uncertain significance (VUS) in the activity of a diagnostic genetic laboratory is a common issue, which is however provisional and needs to be periodically re-evaluated, due to the continuous advancements in our…
View article: Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates Open
Objective We aimed to investigate (1) whether an automated detector can capture scalp high‐frequency oscillations (HFO) in neonates and (2) whether scalp HFO rates can differentiate neonates with seizures from healthy neonates. Methods We …
View article: PB2416: EFFICACY AND SAFETY OF BIOSIMILAR PEGFILGRASTIM AFTER AUTOLOGOUS STEM CELL TRANSPLANT: A COMPARATIVE STUDY WITH BIOSIMILAR FILGRASTIM, LENOGRASTIM AND ORIGINATOR PEGFILGRASTIM
PB2416: EFFICACY AND SAFETY OF BIOSIMILAR PEGFILGRASTIM AFTER AUTOLOGOUS STEM CELL TRANSPLANT: A COMPARATIVE STUDY WITH BIOSIMILAR FILGRASTIM, LENOGRASTIM AND ORIGINATOR PEGFILGRASTIM Open
Topic: 22. Stem cell transplantation - Clinical Background: Biosimilar Pegfilgrastim has been approved for prophylaxis of severe neutropenia duration and febrile neutropenia in cancer patients, including those affected by hematologic malig…
View article: The multifaceted role of mast cells in the pathogenesis of rheumatoid arthritis
The multifaceted role of mast cells in the pathogenesis of rheumatoid arthritis Open
Mast cells (MC) are tissue duelling cells playing an active role in both innate and adaptive immune system. They act as first players in different microbial infections and exert a crucial role in allergy, chronic inflammation, fibrosis, an…
View article: The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures:Single Center Experience and Literature Review
The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures:Single Center Experience and Literature Review Open
Background: Existing therapeutic alternatives for neonatal crises have expanded in recent decades, but no consensus has been reached on protocols based on neonatal seizures. In particular, little is known about the use of midazolam in newb…
View article: P62 USE OF ANTIVIRAL FOR PAUCISINTOMATIC COVID-19 INFECTION IN MULTIPLE MYELOMA PATIENTS UNDERGOING TREATMENT
P62 USE OF ANTIVIRAL FOR PAUCISINTOMATIC COVID-19 INFECTION IN MULTIPLE MYELOMA PATIENTS UNDERGOING TREATMENT Open
Patients with multiple myeloma are at increased risk of mortality from COVID-19 infection and show a lower rate of sieroconversion after vaccination and usually late negativization. In this regard, some studies have shown slight changes in…
View article: Data from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Data from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate Open
The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays …
View article: Supplementary Table s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Supplementary Table s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate Open
Supplementary Table s1. M23-AQP4 mutants. Mutant names, WT and mutated amino acid sequences, position and references are reported. The amino acid positions refer to M1-AQP4.
View article: Supplementary Figure s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Supplementary Figure s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate Open
Supplementary Figure s1. M23-AQP4 C-terminus analysis for the ability to induce morphological changes in glioma cells. a) Schematic representation of the untagged and mCherry-tagged M23-AQP4 isoforms used for the analysis in (b). b) Immuno…
View article: Data from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Data from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate Open
The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays …
View article: Supplementary Table s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate
Supplementary Table s1 from AQP4 Aggregation State Is a Determinant for Glioma Cell Fate Open
Supplementary Table s1. M23-AQP4 mutants. Mutant names, WT and mutated amino acid sequences, position and references are reported. The amino acid positions refer to M1-AQP4.