Explanipedia

Detection of Brain-Derived Cell-Free DNA in Plasma Open

Camilla Pellegrini, Francesco Ravaioli, Sara De Fanti, Chiara Pirazzini, Chiara D’Silva , et al. · 2024

Background: Neuronal loss is a major pathological feature of neurodegenerative diseases. The analysis of plasma cell-free DNA (cfDNA) is an emerging approach to track cell death events in a minimally invasive way and from inaccessible area…

Increased hippocampal epigenetic age in the Ts65Dn mouse model of Down Syndrome Open

Francesco Ravaioli, Fiorenza Stagni, Sandra Guidi, Chiara Pirazzini, Paolo Garagnani , et al. · 2024

Down syndrome (DS) is a segmental progeroid genetic disorder associated with multi-systemic precocious aging phenotypes, which are particularly evident in the immune and nervous systems. Accordingly, people with DS show an increased biolog…

Quadrato Motor Training (QMT) is associated with DNA methylation changes at DNA repeats: A pilot study Open

Fabio Marson, Michele Zampieri, Loredana Verdone, Maria Giulia Bacalini, Francesco Ravaioli , et al. · 2023

The control of non-coding repeated DNA by DNA methylation plays an important role in genomic stability, contributing to health and healthy aging. Mind-body practices can elicit psychophysical wellbeing via epigenetic mechanisms, including …

Increased hippocampal epigenetic age in the Ts65Dn Mouse Model of Down Syndrome Open

Francesco Ravaioli, Fiorenza Stagni, Sandra Guidi, Chiara Pirazzini, Paolo Garagnani , et al. · 2023

Down syndrome (DS) is a segmental progeroid genetic disorder associated to multi-systemic precocious ageing phenotypes, which are particularly evident at the immune and nervous systems. Accordingly, people with DS show an increased biologi…

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation Open

Francesco Ravaioli, Maria Giulia Bacalini, Cristina Giuliani, Camilla Pellegrini, Chiara D’Silva , et al. · 2023

A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices, which have been classified …

Evaluation of DNA Methylation Profiles of LINE-1, Alu and Ribosomal DNA Repeats in Human Cell Lines Exposed to Radiofrequency Radiation Open

Francesco Ravaioli, Maria Giulia Bacalini, Cristina Giuliani, Camilla Pellegrini, Chiara D’Silva , et al. · 2023

A large body of evidence indicates that environmental agents can induce alterations in DNA methylation (DNAm) profiles. Radiofrequency electromagnetic fields (RF-EMFs) are radiations emitted by everyday devices which have been classified a…

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder Open

Luca Baldelli, Chiara Pirazzini, Luisa Sambati, Francesco Ravaioli, Davide Gentilini , et al. · 2023

Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations Open

Katarzyna Malgorzata Kwiatkowska, Eleni Mavrogonatou, Adamantia Papadopoulou, Claudia Sala, Luciano Calzari , et al. · 2023

The aim of the present study was to provide a comprehensive characterization of whole genome DNA methylation patterns in replicative and ionizing irradiation- or doxorubicin-induced premature senescence, exhaustively exploring epigenetic m…

A Targeted Epigenetic Clock for the Prediction of Biological Age Open

Noémie Gensous, Claudia Sala, Chiara Pirazzini, Francesco Ravaioli, Maddalena Milazzo , et al. · 2022

Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict biological age. They are usually based on the analysis of DNA methylation by genome-wide methods, but tar…

DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome Open

Francesco Ravaioli, Michele Zampieri, Luca Morandi, Chiara Pirazzini, Camilla Pellegrini , et al. · 2022

Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21, and 22, trisomy of chromosome 21 confers an excess of rDN…

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients Open

Gaia Meoni, Leonardo Tenori, Sebastian Schade, Cristina Licari, Chiara Pirazzini , et al. · 2022

Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients Open

Elisa Zago, Alessandra Dal Molin, Giovanna Maria Dimitri, Luciano Xumerle, Chiara Pirazzini , et al. · 2022

Advanced age represents one of the major risk factors for Parkinson’s Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA remodelling and agei…

Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients Open

Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R. Schreglmann, Luisa Sambati , et al. · 2021

A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration Open

Camilla Pellegrini, Chiara Pirazzini, Claudia Sala, Luisa Sambati, Igor Yusipov , et al. · 2021

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation (DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect the epigenetic profiles in brain, but their contributi…

Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells Open

Mihaela Zabulica, Tomas Jakobsson, Francesco Ravaioli, Massoud Vosough, Roberto Gramignoli , et al. · 2021

Urea cycle disorders are enzymopathies resulting from inherited deficiencies in any genes of the cycle. In severe cases, currently available therapies are marginally effective, with liver transplantation being the only definitive treatment…

A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project Open

Chiara Pirazzini, Tiago Azevedo, Luca Baldelli, Anna Bartoletti‐Stella, Giovanna Calandra‐Buonaura , et al. · 2020

Age-related DNA methylation changes are sex-specific: a comprehensive assessment Open

Igor Yusipov, Maria Giulia Bacalini, Alena Kalyakulina, Mikhail Krivonosov, Chiara Pirazzini , et al. · 2020

The existence of a sex gap in human health and longevity has been widely documented. Autosomal DNA methylation differences between males and females have been reported, but so far few studies have investigated if DNA methylation is differe…

A meta-analysis of brain DNA methylation across sex, age and Alzheimer’s disease points for accelerated epigenetic aging in neurodegeneration Open

Camilla Pellegrini, Chiara Pirazzini, Claudia Sala, Luisa Sambati, Igor Yusipov , et al. · 2020

Alzheimer’s disease (AD) is characterized by specific alterations of brain DNA methylation (DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect the epigenetic profiles in the brain, but their contri…

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver Open

Noémie Gensous, Francesco Ravaioli, Chiara Pirazzini, Roberto Gramignoli, Ewa Ellis , et al. · 2020

A growing amount of evidence suggests that the downregulation of protein synthesis is an adaptive response during physiological aging, which positively contributes to longevity and can be modulated by nutritional interventions like caloric…

Age-related DNA methylation changes are sex-specific: a comprehensive assessment Open

Igor Yusipov, Maria Giulia Bacalini, Alena Kalyakulina, Mikhail Krivonosov, Chiara Pirazzini , et al. · 2020

In humans, females live longer than males but experience a worse longevity, as genome-wide autosomal DNA methylation differences between males and females have been reported. So far, few studies have investigated if DNA methylation is diff…

Caratterizzazione dei profili molecolari ed epigenetici in modelli cellulari di neurodegenerazione e invecchiamento Open

Francesco Ravaioli · 2020

Parkinson's disease (PD) is the most frequent neurodegenerative disorder after Alzheimer's disease, affecting about 4% of individuals over 80 years of age. Although it is known that advanced age represents one of the main risk factors for …

Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts Open

Massoud Vosough, Francesco Ravaioli, Mihaela Zabulica, Miriam Capri, Paolo Garagnani , et al. · 2019

Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are common occurrences in the aging population. iPSCs could offer regenerative medical …

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli Open

Christine Nardini, Jean-François Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani , et al. · 2018

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature Open

Maria Giulia Bacalini, Claudio Franceschi, Davide Gentilini, Francesco Ravaioli, Xiaoyuan Zhou , et al. · 2018

The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of li…

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells Open

Noémie Gensous, Claudio Franceschi, Bonnie B. Blomberg, Chiara Pirazzini, Francesco Ravaioli , et al. · 2018

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly Open

Francesco Ravaioli, Maria Giulia Bacalini, Claudio Franceschi, Paolo Garagnani · 2018

Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising…

The epigenetic landscape of age-related diseases: the geroscience perspective Open

Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani , et al. · 2017

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process Open

Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani , et al. · 2016

Epigenetic remodeling is one of the major features of the aging process. We recently demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated with age in whole blood. Here we investigated several aspects of age…

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