Francesco S. Loffredo
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View article: Integrating Genetic, Clinical, and Histopathological Data for Definitive Diagnosis of PRKAG2-Related Disease
Integrating Genetic, Clinical, and Histopathological Data for Definitive Diagnosis of PRKAG2-Related Disease Open
Background: PRKAG2-related disease is an autosomal dominant disorder caused by pathogenic variants in the PRKAG2 gene, leading to glycogen accumulation in cardiomyocytes. It is characterized by left ventricular hypertrophy (LVH), ventricul…
View article: Diffuse Cutaneous Systemic Sclerosis Complicated by Serum Amyloid A Protein Cardiac Amyloidosis and Cardiogenic Shock
Diffuse Cutaneous Systemic Sclerosis Complicated by Serum Amyloid A Protein Cardiac Amyloidosis and Cardiogenic Shock Open
View article: The NO Pathway as a Target in Patients with Stable and Advanced Heart Failure: An Additional Arrow in Our Quiver!
The NO Pathway as a Target in Patients with Stable and Advanced Heart Failure: An Additional Arrow in Our Quiver! Open
The nitric oxide (NO) pathway is a fundamental regulator of vascular tone, myocardial function, and inflammation. In heart failure (HF), especially in advanced stages, dysregulation of NO–soluble guanylate cyclase (sGC)–cyclic guanosine mo…
View article: Homocysteine in the Cardiovascular Setting: What to Know, What to Do, and What Not to Do
Homocysteine in the Cardiovascular Setting: What to Know, What to Do, and What Not to Do Open
Homocysteine has long been studied as a potential cardiovascular risk factor due to its biochemical role in endothelial dysfunction, oxidative stress, inflammation, and thrombogenesis. Despite strong epidemiological and mechanistic support…
View article: Cardio-Pulmonary Features of Long COVID: From Molecular and Histopathological Characteristics to Clinical Implications
Cardio-Pulmonary Features of Long COVID: From Molecular and Histopathological Characteristics to Clinical Implications Open
Long COVID is a persistent post-viral syndrome with the significant involvement of both the cardiovascular and pulmonary systems, often extending well beyond the acute phase of SARS-CoV-2 infection. Emerging evidence has highlighted a spec…
View article: Targeting Obesity in Cardiovascular Disease Management: Cardiac Adipose Tissue Is a Real Biomarker!
Targeting Obesity in Cardiovascular Disease Management: Cardiac Adipose Tissue Is a Real Biomarker! Open
Background: Obesity has been defined as a true worldwide “pandemic” by the World Health Organization and represents one of the major public health problems. It is associated with a reduction in life expectancy of about 7–8 years due to rel…
View article: Effect of CMR criteria for return-to-play clearance after acute myocarditis based on 2020 ESC Guidelines on Sports Cardiology
Effect of CMR criteria for return-to-play clearance after acute myocarditis based on 2020 ESC Guidelines on Sports Cardiology Open
Background The 2020 ESC Guidelines on Sports Cardiology set criteria for sports participation in acute myocarditis patients, based on clinical assessments, myocardial damage and inflammation markers, baseline ECG, exercise stress tests, Ho…
View article: Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC)
Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC) Open
The benefits of cardiac rehabilitation (CR) have been demonstrated in patients after myocardial infarction (MI), and in patients with chronic heart failure (HF). The core components of the CR program include improvement in exercise toleran…
View article: Isolated Common Iliac Aneurysm and Dilated Left Ventricle: Kill Two Birds with One Stone?
Isolated Common Iliac Aneurysm and Dilated Left Ventricle: Kill Two Birds with One Stone? Open
Strongyloides stercoralis is a nematode commonly known as roundworm. Humans are the primary host for the parasite and are infected when bare skin is exposed to contaminated soil. Once in the skin of the human host, the larvae migrate to th…
View article: Sodium Nitroprusside: The Forgotten Vasodilator? A Brief Guide for Informed and Safe Use from Heart Failure to Hypertensive Crisis and Aortic Dissection
Sodium Nitroprusside: The Forgotten Vasodilator? A Brief Guide for Informed and Safe Use from Heart Failure to Hypertensive Crisis and Aortic Dissection Open
Sodium nitroprusside (SNP) is a powerful vasodilator approved for treating acute hypertensive crises, acute heart failure, aortic dissection, and both controlled perioperative hypotension and perioperative hypertension. Its unique ability …
View article: The Desmoplakin Phenotype Spectrum: Is the Inflammation the “Fil Rouge” Linking Myocarditis, Arrhythmogenic Cardiomyopathy, and Uncommon Autoinflammatory Systemic Disease?
The Desmoplakin Phenotype Spectrum: Is the Inflammation the “Fil Rouge” Linking Myocarditis, Arrhythmogenic Cardiomyopathy, and Uncommon Autoinflammatory Systemic Disease? Open
Myocarditis is an inflammatory condition of cardiac tissue presenting significant variability in clinical manifestations and outcomes. Its etiology is diverse, encompassing infectious agents (primarily viruses, but also bacteria, protozoa,…
View article: Evolving Concepts of the SCORE System: Subtracting Cholesterol from Risk Estimation: A Way for a Healthy Longevity?
Evolving Concepts of the SCORE System: Subtracting Cholesterol from Risk Estimation: A Way for a Healthy Longevity? Open
The role of cholesterol, mainly low-density lipoproteins (LDL-C), as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) is now established and accepted by the international scientific community. Based on this evidence,…
View article: Mechanical load regulates the proliferation of multiple cell types in the heart
Mechanical load regulates the proliferation of multiple cell types in the heart Open
Funding Acknowledgements None. Introduction The adult mammalian heart has a poor regenerative and angiogenic potential. At the same time, both primary cardiac tumors and cardiac metastases are extremely rare. This suggests that shared mech…
View article: “A BROKEN TRANSPLANTED HEART”: A CASE OF TAKOTSUBO SYNDROME IN A HEART TRANSPLANT RECIPIENT
“A BROKEN TRANSPLANTED HEART”: A CASE OF TAKOTSUBO SYNDROME IN A HEART TRANSPLANT RECIPIENT Open
75–year–old female patient went to the emergency department for oppressive chest pain radiating to the left arm and dyspnea, developed after an argument with family members. The patient underwent heart transplant in 2010 because of chronic…
View article: NEW ONSET OF PULMONARY HYPERTENSION IN A PATIENT AFFECTED BY RECURRENT LUNG CANCER
NEW ONSET OF PULMONARY HYPERTENSION IN A PATIENT AFFECTED BY RECURRENT LUNG CANCER Open
39 years old non–smoker female patient came to our observation in July 2023 complaining dyspnea on mild exertion. She had a history of lung adenocarcinoma with epidermal growth factor receptor (EGFR) positive for exon 19 deletion treated w…
View article: DESMOPLAKIN ASSOCIATED NON DILATED LEFT VENTRICULAR CARDIOMYOPATHY TREATED WITH ANAKINRA
DESMOPLAKIN ASSOCIATED NON DILATED LEFT VENTRICULAR CARDIOMYOPATHY TREATED WITH ANAKINRA Open
A 24 year old female patient experienced,from 2010 to November 2023,12 myocarditis–like episodes, often related to emotional stress, characterized by chest pain,increased markers of myocardial necrosis, normal C–reactive Protein values,nor…
View article: Mitophagy modulation for the treatment of cardiovascular diseases
Mitophagy modulation for the treatment of cardiovascular diseases Open
Background Defects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged a…
View article: Arrhythmogenic Left Ventricular Cardiomyopathy: From Diagnosis to Risk Management
Arrhythmogenic Left Ventricular Cardiomyopathy: From Diagnosis to Risk Management Open
Purpose of Review: Left ventricular arrhythmogenic cardiomyopathy (ALVC) is a rare and poorly characterized cardiomyopathy that has recently been reclassified in the group of non-dilated left ventricular cardiomyopathies. This review aims …
View article: Apoptosis, a useful marker in the management of hot‐phase cardiomyopathy?
Apoptosis, a useful marker in the management of hot‐phase cardiomyopathy? Open
Aims ‘Hot phases’, characterized by chest pain and troponin release, may represent the first clinical presentation of arrhythmogenic cardiomyopathies. Differential diagnosis with acute myocarditis is an unmet challenge for the clinicians. …
View article: Constrictive Pericarditis After a Stab Wound of the Chest
Constrictive Pericarditis After a Stab Wound of the Chest Open
Constrictive pericarditis is an uncommon cause of diastolic heart failure resulting by impaired cardiac filling from an inelastic pericardium. We present a case of constrictive pericarditis in a 39-years-old man following thoracic penetrat…
View article: Catch the Cath or Not? A Hamletic Dilemma after 10 Years
Catch the Cath or Not? A Hamletic Dilemma after 10 Years Open
In the last few years, a tremendous advancement has been made in the therapeutical management of several diseases with an increasing need for parental drug administration. To avoid repeated venous insertions and the patient’s anxiety relat…
View article: Non-Conventional Risk Factors: “Fact” or “Fake” in Cardiovascular Disease Prevention?
Non-Conventional Risk Factors: “Fact” or “Fake” in Cardiovascular Disease Prevention? Open
Cardiovascular diseases (CVDs), such as arterial hypertension, myocardial infarction, stroke, heart failure, atrial fibrillation, etc., still represent the main cause of morbidity and mortality worldwide. They significantly modify the pati…
View article: P404 MYOCARDIAL WORK EVALUATION IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
P404 MYOCARDIAL WORK EVALUATION IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT Open
Background myocardial work (MW) is a novel echocardiographic technique that enables the study of left ventricular performance. It overcomes speckle tracking echocardiography (STE) limitations, dependent on afterload, which is increased in …
View article: P200 A POSITIVE CORRELATION BETWEEN THE OVERALL ECHOGENICITY OF CAROTID INTIMA MEDIA COMPLEX AND ARTERIAL STIFFNESS OF HYPERTENSIVE PATIENTS: BEYOND THE INTIMA MEDIA THICKNESS ASSESSMENT
P200 A POSITIVE CORRELATION BETWEEN THE OVERALL ECHOGENICITY OF CAROTID INTIMA MEDIA COMPLEX AND ARTERIAL STIFFNESS OF HYPERTENSIVE PATIENTS: BEYOND THE INTIMA MEDIA THICKNESS ASSESSMENT Open
According to the latest ESC guidelines on CVD prevention (2021) arterial stiffness (AS) still has a role in predicting future CVD risk and defining patients’ CVD risk level. However, significative measurement difficulties make a widespread…
View article: P476 TOLERATED SUSTAINED VENTRICULAR FIBRILLATION IN LVAD RECIPIENT: THE WALKING DEAD
P476 TOLERATED SUSTAINED VENTRICULAR FIBRILLATION IN LVAD RECIPIENT: THE WALKING DEAD Open
A 73–year–old man comes to the cardiac surgery clinic, due to the onset of an arrhythmic storm. In 1999, the patient was diagnosed with dilated cardiomyopathy with finding of a pathogenic mutation of the MYH7 gene by NGS panel analysis. Be…
View article: P366 FULMINANT MYOCARDITIS WITH SPONTANEOUS RESOLUTION AFTER COVID 19 AND ALLERGIC EPISODE: MIS–A OR ALLERGIC MYOCARDITIS?
P366 FULMINANT MYOCARDITIS WITH SPONTANEOUS RESOLUTION AFTER COVID 19 AND ALLERGIC EPISODE: MIS–A OR ALLERGIC MYOCARDITIS? Open
Clinical case 23–year–old male. No medical history Not vaccinated for Sars–Cov2; Recent Sars–Cov2 infection (negative antigenic swab on 03/01/22); Pharyngodynia treated with ibuprofen + ciprofloxacin and amoxicillin ac clavulanic acid(susp…
View article: P26 TRANSIENT GLOBAL AMNESIA AS A POSSIBLE CONSEQUENCE OF ICA DISSECTION: A CASE REPORT
P26 TRANSIENT GLOBAL AMNESIA AS A POSSIBLE CONSEQUENCE OF ICA DISSECTION: A CASE REPORT Open
Case Report A 42–year–old woman was carried to emergency room lamenting sudden memory loss. Her husband witnessed the onset of the episode. No recent head trauma was reported, blood pressure was under control. Anterograde and retrograde me…
View article: P362 SHORT TERM EFFECTIVENESS OF A NOVEL NUTRACEUTICAL FOR THE MANAGEMENT OF HYPERCHOLESTEROLEMIA IN PATIENTS WITH LOW TO MODERATE CARDIOVASCULAR RISK: A MULTICENTER PRIMARY CARE OBSERVATIONAL
P362 SHORT TERM EFFECTIVENESS OF A NOVEL NUTRACEUTICAL FOR THE MANAGEMENT OF HYPERCHOLESTEROLEMIA IN PATIENTS WITH LOW TO MODERATE CARDIOVASCULAR RISK: A MULTICENTER PRIMARY CARE OBSERVATIONAL Open
Purpose: Increasing evidence reinforces the benefits of reduction of low–density lipoprotein (LDL–C) levels on cardiovascular outcomes. Different targets are suggested based on cardiovascular risk (CVR). According to the current European g…
View article: P359 A POSSIBLE ROLE OF A NOVEL NUTRACEUTICAL COMPOUND FOR IBS IN TRIGLYCERIDES–LOWERING EFFECT
P359 A POSSIBLE ROLE OF A NOVEL NUTRACEUTICAL COMPOUND FOR IBS IN TRIGLYCERIDES–LOWERING EFFECT Open
In the last few years, growing evidence indicate that gut miocrobiome is linked to irritable bowel syndrome (IBS) and atherosclerotic disorders. The effect on lipid metabolism seems to be one of the potential mechanisms by which gut microb…
View article: P434 PAY ATTENTION TO PARA–AORTIC LYMPH NODES: A PITFALL IN ECHOGRAPHIC ABDOMINAL AORTIC ANEURYSM DIAGNOSIS
P434 PAY ATTENTION TO PARA–AORTIC LYMPH NODES: A PITFALL IN ECHOGRAPHIC ABDOMINAL AORTIC ANEURYSM DIAGNOSIS Open
A 65–year–old woman was scheduled for coronary angiography during the pre–surgery evaluation because of an abdominal aortic aneurysm (AAA) detected at ultrasound (Figure). The patient referred worsening dyspnoea and asthenia in the last fe…