Francesco Sciancalepore
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View article: Frailty and the brain: A narrative review of functional and pathological correlates
Frailty and the brain: A narrative review of functional and pathological correlates Open
Frailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with frailty remain insufficiently explored. …
View article: Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study
Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study Open
Background/Objectives: The etiology of dementia is complex and multifactorial, with both genetic and environmental factors contributing to its onset. The Lancet Commission has identified several risk factors for this condition, but it is i…
View article: Management and Care for People Living With Dementia and Their Caregivers: Findings From an Italian National Survey on Caregivers and Services Use
Management and Care for People Living With Dementia and Their Caregivers: Findings From an Italian National Survey on Caregivers and Services Use Open
Background Increasing life expectancy will lead to more people living with dementia (PLwD) and, consequently, more caregivers experiencing burden. Caregivers burden is influenced by characteristics of both PLwD and caregivers themselves, a…
View article: Advancing dementia care: a review of Italy’s public health response within the WHO Global Action Plan and European strategies
Advancing dementia care: a review of Italy’s public health response within the WHO Global Action Plan and European strategies Open
Introduction Dementia is a growing global public health priority, with the WHO Global Action Plan (GAP) calling for coordinated efforts worldwide. Italy, one of the oldest nations globally, faces a significant challenge with approximately …
View article: Correction to: The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta‑analysis
Correction to: The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta‑analysis Open
View article: Multi-Center 3D CNN for Parkinson’s disease diagnosis and prognosis using clinical and T1-weighted MRI data
Multi-Center 3D CNN for Parkinson’s disease diagnosis and prognosis using clinical and T1-weighted MRI data Open
View article: The prognosis of mild cognitive impairment: A systematic review and meta‐analysis
The prognosis of mild cognitive impairment: A systematic review and meta‐analysis Open
INTRODUCTION Knowledge gaps remain about the prognosis of mild cognitive impairment (MCI). Conversion rates to dementia vary widely, and reversion to normal cognition has gained attention. This review updates evidence on MCI conversion ris…
View article: Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services
Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services Open
View article: The Italian guideline on diagnosis and treatment of dementia and mild cognitive impairment
The Italian guideline on diagnosis and treatment of dementia and mild cognitive impairment Open
Introduction Approximately 2 million people in Italy are currently living with dementia or mild cognitive impairment (MCI), and 4 million are involved as family members or caregivers. Considering the significant impact of dementia, the Ita…
View article: The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta-analysis
The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta-analysis Open
View article: Prevalence, Incidence, and Mortality of Myasthenia Gravis and Myasthenic Syndromes: A Systematic Review
Prevalence, Incidence, and Mortality of Myasthenia Gravis and Myasthenic Syndromes: A Systematic Review Open
Introduction: No systematic reviews were published in the last years investigating epidemiological data, involving myasthenia gravis (MG) and related myasthenic syndromes. This systematic review aimed to estimate the prevalence, incidence,…
View article: Development of a prediction model of conversion to Alzheimer’s disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project
Development of a prediction model of conversion to Alzheimer’s disease in people with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project Open
Background In recent years, significant efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (mild cognitive impairment, MCI) and/or early stages of Alz…
View article: Incidence and prevalence of Amyotrophic Lateral Sclerosis in three Italian Regions: a study based on health administrative databases.
Incidence and prevalence of Amyotrophic Lateral Sclerosis in three Italian Regions: a study based on health administrative databases. Open
ALS prevalence and incidence in three Central Italy Regions are rather similar, but slightly higher than those previously reported. This finding is plausible, given that previous results relate to at least ten years ago and evidenced incre…
View article: Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services
Neuropsychological tests at the Italian Centers for Cognitive Disorders and Dementias: results from a survey on 450 specialized services Open
Background The Italian Fund for Alzheimer’s and other dementias approved in 2020 enabled the conducting of a survey in Italian CCDDs to analyse the organization, the administrative features and the professionals’ characteristics. Aims To i…
View article: Drug Use Patterns in Myasthenia Gravis: A Real-World Population-Based Cohort Study in Italy
Drug Use Patterns in Myasthenia Gravis: A Real-World Population-Based Cohort Study in Italy Open
Background: In the context of a comparative study of efficacy and safety of drugs used in rare neuromuscular and neurodegenerative diseases (CAESAR—call AIFA_FV_2012-13-14), we assessed the use patterns of drugs indicated for myasthenia gr…
View article: Childhood Trauma, Mentalization and Obsessive Compulsive Symptoms in a Non-Clinical Sample: A Mediation Analysis Study.
Childhood Trauma, Mentalization and Obsessive Compulsive Symptoms in a Non-Clinical Sample: A Mediation Analysis Study. Open
The findings contribute to elucidate the complex relationships between CT, mentalization capacity, and OCS, supporting the possibility that mentalization impairments, arising from CT, may affect top-down control mechanisms thus contributin…
View article: The Relationship of Frailty with Psychopathology, Childhood Traumas and Insecure Attachment in Young Adults: A Cross-Sectional Investigation
The Relationship of Frailty with Psychopathology, Childhood Traumas and Insecure Attachment in Young Adults: A Cross-Sectional Investigation Open
View article: Risk of stroke with different levels of leisure-time physical activity: a systematic review and meta-analysis of prospective cohort studies
Risk of stroke with different levels of leisure-time physical activity: a systematic review and meta-analysis of prospective cohort studies Open
Background Leisure-time physical activity (LTPA) protects against vascular diseases. Whether and to what extent different levels of LTPA, including lower ones, benefit stroke prevention is still unclear. Methods We searched prospective coh…
View article: Development of a prediction model of conversion to Alzheimer’s disease in subjects with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project
Development of a prediction model of conversion to Alzheimer’s disease in subjects with mild cognitive impairment: the statistical analysis plan of the INTERCEPTOR project Open
Background In recent years, considerable efforts have been directed towards the research and development of disease-modifying therapies for dementia. These drugs focus on prodromal (Mild Cognitive Impairment, MCI) and/or early stages of Al…
View article: Potentially inappropriate drug use in myasthenia gravis: a real-world population-based cohort study in Italy
Potentially inappropriate drug use in myasthenia gravis: a real-world population-based cohort study in Italy Open
Introduction To evaluate the use of pyridostigmine in presence of contraindications, and the use of concomitant potentially contraindicated drugs in a cohort of patients affected by Myasthenia Gravis (MG) in the Italian Regions of Lazio, T…
View article: Adherence to riluzole therapy in patients with amyotrophic lateral sclerosis in three Italian regions—The CAESAR study
Adherence to riluzole therapy in patients with amyotrophic lateral sclerosis in three Italian regions—The CAESAR study Open
Purpose Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease. Riluzole may increase survival and delay the need for mechanical ventilation. The CAESAR project (‘Comparative evaluation of the efficacy and safety of drugs …
View article: Frequency and characterization of cognitive impairments in patients diagnosed with paediatric central nervous system tumours: a systematic review
Frequency and characterization of cognitive impairments in patients diagnosed with paediatric central nervous system tumours: a systematic review Open
Background This systematic review has been conducted with the aim of characterizing cognitive deficits and analyzing their frequency in survivors of paediatric Central Nervous System tumours. Materials and methods All literature published …
View article: Amyotrophic Lateral Sclerosis in three Italian regions: prevalence and incidence based on health administrative databases
Amyotrophic Lateral Sclerosis in three Italian regions: prevalence and incidence based on health administrative databases Open
Background Studies of the epidemiology of amyotrophic lateral sclerosis (ALS) are numerous, with incidence and prevalence estimates varying widely depending on population characteristics, geographical areas, and available data sources. The…
View article: Riluzole use in presence of contraindications in adults affected by amyotrophic lateral sclerosis and its off-label use in other motor neuron diseases: Findings from an Italian multicentre study (the CAESAR project)
Riluzole use in presence of contraindications in adults affected by amyotrophic lateral sclerosis and its off-label use in other motor neuron diseases: Findings from an Italian multicentre study (the CAESAR project) Open
Background: This analysis describes the use of riluzole in amyotrophic lateral sclerosis (ALS) individuals with contraindications and off-label use for subjects with other motor neuron diseases (o-MND) in the Italian regions of Latium, Tus…
View article: The Italian fund for Alzheimer's and other dementias: strategies and objectives to face the dementia challenge.
The Italian fund for Alzheimer's and other dementias: strategies and objectives to face the dementia challenge. Open
The Italian Fund for Alzheimer's and other dementias was approved and signed in December 2021. The Fund is financed with 15 million euros in three years. The main goal is to provide new strategies in the field of dementia with a Public Hea…
View article: Computer-Based Cognitive Training in Children with Primary Brain Tumours: A Systematic Review
Computer-Based Cognitive Training in Children with Primary Brain Tumours: A Systematic Review Open
Background: Late neurocognitive sequelae are common among long-term brain tumour survivors, resulting in significantly worse quality of life. Cognitive rehabilitation through specific APP/software for PC/tablets represents an innovative in…
View article: A nationwide survey of Italian Centers for Cognitive Disorders and Dementia on the provision of care for international migrants
A nationwide survey of Italian Centers for Cognitive Disorders and Dementia on the provision of care for international migrants Open
Background More than 500,000 dementia cases can be estimated among migrants living in Europe. There is the need to collect “real world” data on the preparedness of healthcare services to support the inclusion of migrants in the public heal…
View article: Frailty in Caregivers and Its Relationship with Psychological Stress and Resilience: A Cross-Sectional Study Based on the Deficit Accumulation Model
Frailty in Caregivers and Its Relationship with Psychological Stress and Resilience: A Cross-Sectional Study Based on the Deficit Accumulation Model Open
The results provide insight on the relationship of frailty with caregiving, psychological stress, and resilience, with potential implications for the clinical management of individuals exposed to chronic emotional strain.
View article: A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects
A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects Open
Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess i…
View article: Use of Biomarkers in Ongoing Research Protocols on Alzheimer’s Disease
Use of Biomarkers in Ongoing Research Protocols on Alzheimer’s Disease Open
The present study aimed to describe and discuss the state of the art of biomarker use in ongoing Alzheimer’s disease (AD) research. A review of 222 ongoing phase 1, 2, 3, and 4 protocols registered in the clinicaltrials.gov database was pe…