Francesco Tamiro
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View article: The dynamic role of TRIM8, a novel ciliary protein, during various stages of mitosis
The dynamic role of TRIM8, a novel ciliary protein, during various stages of mitosis Open
View article: TAF1 is required for fetal but not adult hematopoiesis in mice
TAF1 is required for fetal but not adult hematopoiesis in mice Open
While many sequence-specific transcription factors (TFs) have been identified as key regulators of hematopoietic stem cell (HSC) lineage determination, the function of general TFs in HSC behavior is poorly understood. To evaluate the funct…
View article: Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosis
Novel ciliary protein TRIM8 is a multifunctional workhorse during mitosis Open
TRIM8 is an E3 ubiquitin ligase that functions as both a tumour suppressor and an oncoprotein. Earlier, we reported that TRIM8 interacts with key regulators of mitotic spindle assembly, and that TRIM8 knockdown results in mitotic delay and…
View article: Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition Open
View article: The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis
The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis Open
Notch signaling is an evolutionary conserved pathway with a key role in tissue homeostasis, differentiation and proliferation. It was reported that Notch1 receptor negatively regulates mouse osteoclast development and formation by inhibiti…
View article: A functional role of Ephrin type-B receptor 6 (EPHB6) in T-cell acute lymphoblastic leukemia
A functional role of Ephrin type-B receptor 6 (EPHB6) in T-cell acute lymphoblastic leukemia Open
View article: The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression Open
During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical against infection or tissue injury. If unresolved, this process leads to sustai…
View article: Additional file 5 of Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia
Additional file 5 of Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia Open
Additional file 5: Table S1. miRNA normalized (U6) expression data. Table S2. Mod-A and Mod-B gene sets. Table S3. MSigDB analysis of Mod-B genes. Table S4. Liu et al. T-ALL cohort stratified according to ssGSEA analysis performed with Mod…
View article: Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia
Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive T-cell malignancy characterized by genotypically-defined and phenotypically divergent cell populations, governed by adaptive landscapes. Clonal expansions are associated to genet…
View article: Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia
Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is a T-cell malignancy characterized by cell subsets and enriched with leukemia-initiating cells (LICs). β-Catenin modulates LIC activity in T-ALL. However, its role in maintaining established le…
View article: Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-Cell Acute Lymphoblastic Leukemia
Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-Cell Acute Lymphoblastic Leukemia Open
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive T-cell malignancy characterized by genotypically-defined and phenotypically divergent cell populations, governed by adaptive landscapes. Clonal expansions are associated to genet…
View article: COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic Profiling
COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic Profiling Open
COVID-19 is a viral infection, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and characterized by a complex inflammatory process and clinical immunophenotypes. Nowadays, several alterations of immune response w…
View article: Associations between Allelic Variants of the Human IgH 3′ Regulatory Region 1 and the Immune Response to BNT162b2 mRNA Vaccine
Associations between Allelic Variants of the Human IgH 3′ Regulatory Region 1 and the Immune Response to BNT162b2 mRNA Vaccine Open
The escalation of Coronavirus disease 2019 (COVID-19) has required the development of safe and effective vaccines against the severe acute respiratory syndrome coronavirus 2-associated (SARS-CoV-2), which is the causative agent of the dise…
View article: Spike-specific immune response induced by BNT162b2 mRNA vaccine in former COVID-19 patients and high responsive subjects
Spike-specific immune response induced by BNT162b2 mRNA vaccine in former COVID-19 patients and high responsive subjects Open
Background: The worldwide escalation of Coronavirus Disease 2019 (COVID-19) has urgently required the development of safe and effective vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causati…
View article: Targeting Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia
Targeting Leukemia-Initiating Cells in Acute Lymphoblastic Leukemia Open
The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like c…
View article: Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo
Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo Open