Francesco Vladimiro Segala
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View article: Implementation of infection prevention and control components in Italian hospitals based on a nationwide survey on behalf of INSIEME project
Implementation of infection prevention and control components in Italian hospitals based on a nationwide survey on behalf of INSIEME project Open
We aim to assess the state-of-the-art of Infection Prevention and Control (IPC) practices and their results in Italian healthcare facilities 6 years after the kick-off of the new National Plan for the Control of Antibiotic Resistance (PNCA…
View article: When microbiology is missing: A prospective observational study on empirical first-line antibiotic treatment (FLAT) in Ethiopia
When microbiology is missing: A prospective observational study on empirical first-line antibiotic treatment (FLAT) in Ethiopia Open
In a low-resource hospital setting without microbiological support, empirical FLAT achieved a relatively low failure rate. However, failures were clinically significant, leading to escalation of therapy and adverse outcomes. Strengthening …
View article: Impact of social behavioural change for reducing risk of climate-sensitive infectious diseases in the emergency context of Cabo Delgado, Mozambique: a pre-post intervention study
Impact of social behavioural change for reducing risk of climate-sensitive infectious diseases in the emergency context of Cabo Delgado, Mozambique: a pre-post intervention study Open
The intervention improved preparedness in several domains, emphasizing the effectiveness of SBC approaches in reducing risk factors for climate-sensitive diseases. However, continued efforts are needed to address vulnerabilities, particula…
View article: Knowledge, practices, educational needs and hospital engagement in Infection Prevention and Control (IPC) among Italian healthcare workers and students: results from a national multicentre survey
Knowledge, practices, educational needs and hospital engagement in Infection Prevention and Control (IPC) among Italian healthcare workers and students: results from a national multicentre survey Open
Objective This study assesses the knowledge, practices, educational needs and hospital engagement in IPC among healthcare workers (HCWs) and students in Italy. Methods A national cross-sectional observational study was conducted from April…
View article: P11. Cefiderocol for Gram-negative infections: comparing monotherapy and combination therapy in the multicenter CEFI-BAC study
P11. Cefiderocol for Gram-negative infections: comparing monotherapy and combination therapy in the multicenter CEFI-BAC study Open
Background Real-life data on cefiderocol for Gram-negative infections remain limited. We aimed to evaluate factors associated with mortality in patients treated with cefiderocol either as monotherapy or combination therapy. Methods A retro…
View article: Prolonged survival in HIV-associated Progressive Multifocal Leukoencephalopathy treated with Pembrolizumab: a case series on treatment and long-term follow-up
Prolonged survival in HIV-associated Progressive Multifocal Leukoencephalopathy treated with Pembrolizumab: a case series on treatment and long-term follow-up Open
Progressive Multifocal Leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system (CNS) caused by human polyomavirus JC virus, with high mortality rate in people living with HIV (PLWH), without an effective s…
View article: Transmission of autochthonous Aedes-borne arboviruses and related public health challenges in Europe 2007–2023: a systematic review and secondary analysis
Transmission of autochthonous Aedes-borne arboviruses and related public health challenges in Europe 2007–2023: a systematic review and secondary analysis Open
This work was partly funded by the Italian Ministry of Health (Ricerca corrente) and by the European Union (Next Generation EU, Missione 4 Componente 1 CUP H93C22000640007).
View article: Insights into the ecological and climate crisis: Emerging infections threatening human health
Insights into the ecological and climate crisis: Emerging infections threatening human health Open
The Anthropocene era is marked by unprecedented human-induced alterations to the environment, resulting in a climate emergency and widespread ecological deterioration. A staggering number of up to one million species of plants and animals …
View article: Comparative effectiveness of chest ultrasound, chest X-ray and computer-aided diagnostic (CAD) for tuberculosis diagnosis in low-resource setting: study protocol for a cross-sectional study from Ethiopia
Comparative effectiveness of chest ultrasound, chest X-ray and computer-aided diagnostic (CAD) for tuberculosis diagnosis in low-resource setting: study protocol for a cross-sectional study from Ethiopia Open
Introduction Early and accurate diagnosis of pulmonary tuberculosis (TB) is crucial for timely treatment and prevention of transmission, but diagnostic challenges persist due to complex symptoms and limitations in diagnostic tools. Chest X…
View article: Protective role of vaccination on the development of long COVID: data from a large, multicenter, prospective cohort study
Protective role of vaccination on the development of long COVID: data from a large, multicenter, prospective cohort study Open
View article: Rapid de-escalation of anti-MRSA therapy guided by S. aureus nares screening for patients with pneumonia: protocol of a randomized controlled trial (SNAP study)
Rapid de-escalation of anti-MRSA therapy guided by S. aureus nares screening for patients with pneumonia: protocol of a randomized controlled trial (SNAP study) Open
Introduction The current Infectious Disease Society of America and American Thoracic Society (IDSA/ATS) guidelines recommend linezolid or vancomycin as an empiric treatment for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia i…
View article: Measuring preparedness to infectious diseases among people exposed to climate disasters in Cabo Delgado, Mozambique: a cross-sectional study
Measuring preparedness to infectious diseases among people exposed to climate disasters in Cabo Delgado, Mozambique: a cross-sectional study Open
View article: Knowledge, Attitudes, and Practices toward Antimicrobial Resistance among Young Italian Nurses and Students: A Multicenter, Cross-Sectional Study
Knowledge, Attitudes, and Practices toward Antimicrobial Resistance among Young Italian Nurses and Students: A Multicenter, Cross-Sectional Study Open
Background: Nurses play a pivotal role in combating antimicrobial resistance (AMR). However, the success of local and national AMR containment efforts hinges on the knowledge, attitude, and practice (KAP) of nursing staff and undergraduate…
View article: Perspectives on climate action and the changing burden of infectious diseases among young Italian doctors and students: a national survey
Perspectives on climate action and the changing burden of infectious diseases among young Italian doctors and students: a national survey Open
Background The eco-climatic crisis has been defined by the World Health Organization as the “single biggest health threat facing humanity,” influencing both the emergence of zoonoses and the spread of vector-borne and water-borne diseases.…
View article: Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study
Long-Term Impairment of Working Ability in Subjects under 60 Years of Age Hospitalised for COVID-19 at 2 Years of Follow-Up: A Cross-Sectional Study Open
Background: Coronavirus disease 2019 (COVID-19) can lead to persistent and debilitating symptoms referred to as Post-Acute sequelae of SARS-CoV-2 infection (PASC) This broad symptomatology lasts for months after the acute infection and imp…
View article: Real life experience on the use of Remdesivir in patients admitted to COVID-19 in two referral Italian hospital: a propensity score matched analysis
Real life experience on the use of Remdesivir in patients admitted to COVID-19 in two referral Italian hospital: a propensity score matched analysis Open
Remdesivir (RDV) was the first Food and Drug Administration (FDA)-approved medication for COVID-19, with discordant data on efficacy in reducing mortality risk and disease progression. In the context of a dynamic and rapidly changing pande…
View article: Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study
Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study Open
View article: Knowledge, attitudes, and practices about HIV and other sexually transmitted infections among High School students in Southern Italy: A cross-sectional survey
Knowledge, attitudes, and practices about HIV and other sexually transmitted infections among High School students in Southern Italy: A cross-sectional survey Open
High School students, recognized as a high-risk group for sexually transmitted infections (STIs), were the focal point of an educational campaign in Southern Italy to share information and good practices about STIs and HIV/AIDS. A baseline…
View article: Tuberculosis Outcomes Among International Migrants Living in Europe Compared to the Non-Migrant Population: A Systematic Review and Meta-Analysis
Tuberculosis Outcomes Among International Migrants Living in Europe Compared to the Non-Migrant Population: A Systematic Review and Meta-Analysis Open
View article: Prevalence of Sexually Transmitted Infections and Predictors for Loss to Follow Up among Marginalized Homeless and Migrant Communities: a Cross-Sectional Study
Prevalence of Sexually Transmitted Infections and Predictors for Loss to Follow Up among Marginalized Homeless and Migrant Communities: a Cross-Sectional Study Open
Among homeless people and agricultural migrant workers, STI prevalence was high, and only half of the population returned to collect test results. The study underscores the urgent need for targeted interventions and policy reevaluation to …
View article: Association of IgG4-Related Disease with Human Inborn Errors of Immunity
Association of IgG4-Related Disease with Human Inborn Errors of Immunity Open
View article: Tuberculosis Outcomes Among International Migrants Living in Europe Compared to the Non-Migrant Population: A Systematic Review and Meta-Analysis
Tuberculosis Outcomes Among International Migrants Living in Europe Compared to the Non-Migrant Population: A Systematic Review and Meta-Analysis Open
View article: Incidence and burden of long COVID in Africa: a systematic review and meta-analysis
Incidence and burden of long COVID in Africa: a systematic review and meta-analysis Open
Long COVID, also known as “post-acute sequelae of COVID-19,” affects at least 65 million individuals worldwide with a wide spectrum of symptoms that may last weeks, months, or permanently. Its epidemiology and burden in Africa are unclear.…
View article: Active close contact investigation of tuberculosis through computer-aided detection and stool Xpert MTB/RIF among people living in Oromia Region, Ethiopia (CADOOL Study): protocol for a prospective, cross-sectional study
Active close contact investigation of tuberculosis through computer-aided detection and stool Xpert MTB/RIF among people living in Oromia Region, Ethiopia (CADOOL Study): protocol for a prospective, cross-sectional study Open
Introduction Pulmonary tuberculosis (TB) is an infectious disease with high incidence in low-income countries (LICs); it remains one of the infectious diseases with the highest mortality in the world, especially in LICs. It is crucial to r…
View article: Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis
Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis Open
Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they are at increased risk for disease progression and for obstetric complications, such as premature labor, miscarriage, preeclampsia, cesare…
View article: COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study
COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study Open
Both SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinic…
View article: Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study
Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study Open
Background: The increased vascular risk associated with varicella–zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People …
View article: Impact of the COVID-19 pandemic on malaria in pregnancy indicators in Northern Uganda: a joinpoint regression analysis
Impact of the COVID-19 pandemic on malaria in pregnancy indicators in Northern Uganda: a joinpoint regression analysis Open
In our study, the COVID-19 pandemic significantly reduced access to ANC visits and IPTp uptake. However, the healthcare system maintained its capacity for managing malaria cases, first antenatal visits, and institutional deliveries.Trial r…
View article: Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living With HIV: Data From a Retrospective Cohort Study
Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living With HIV: Data From a Retrospective Cohort Study Open
Background: The increased vascular risk associated to Varicella- Zoster Virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds true for Peo…
View article: Real Life Experience on the Use of Remdesivir in Patients Admitted to Covid-19 in Two Referral Italian Hospital: a Propensity Score Matched Analysis
Real Life Experience on the Use of Remdesivir in Patients Admitted to Covid-19 in Two Referral Italian Hospital: a Propensity Score Matched Analysis Open
Introduction: Remdesivir (RDV) was the first Food and Drug Administration (FDA)-approved medication for COVID-19, with discordant data on efficacy in reducing mortality risk and disease progression. In the context of a dynamic and rapidly …