Franceska Dedeurwaerdere
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View article: From AVM to cavernoma: the long-term effects of stereotactic radiosurgery
From AVM to cavernoma: the long-term effects of stereotactic radiosurgery Open
Radiation-induced cavernomas are rare but significant late complications of stereotactic radiosurgery (SRS) for arteriovenous malformations (AVMs). We report the case of a 66-year-old male who developed a contrast-enhancing lesion with cys…
View article: Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors Open
View article: A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer
A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer Open
The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center stu…
View article: P109: Multimodal Predictive Modelling for Axillary Nodal Involvement: Integrating Pathology and Clinicopathological EUSOMA Data
P109: Multimodal Predictive Modelling for Axillary Nodal Involvement: Integrating Pathology and Clinicopathological EUSOMA Data Open
View article: Unlocking precision oncology by establishing a nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer: the BALLETT study
Unlocking precision oncology by establishing a nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer: the BALLETT study Open
The increasing complexity of advanced-stage cancer management, coupled with the growing availability of targeted therapies, necessitates innovative approaches to treatment decision-making. The Belgian Approach for Local Laboratory Extensiv…
View article: Versatile, accessible cross-platform molecular profiling of central nervous system tumors: web-based, prospective multi-center validation
Versatile, accessible cross-platform molecular profiling of central nervous system tumors: web-based, prospective multi-center validation Open
The 2021 WHO classification underscores the importance of molecular data integration in Central Nervous System (CNS) tumor diagnostics. However, currently used assays have disadvantages due to technical complexity, required equipment and r…
View article: Rational thresholding of circulating tumor DNA concentration for improved surveillance of metastatic breast cancer
Rational thresholding of circulating tumor DNA concentration for improved surveillance of metastatic breast cancer Open
View article: 28P Rational thresholding of circulating tumor DNA copy number for early detection of disease progression in advanced metastatic breast cancer
28P Rational thresholding of circulating tumor DNA copy number for early detection of disease progression in advanced metastatic breast cancer Open
Circulating tumor DNA (ctDNA) is promising as tumor-specific marker for progression surveillance in metastatic cancer. Our aim was to investigate the diagnostic power of ctDNA level for disease progression in metastatic breast cancer and t…
View article: Successful Multimodal Therapy with Intracerebral Liposomal Amphotericin B and Systemic High-Dose Isavuconazole in Proven Disseminated Aspergillosis
Successful Multimodal Therapy with Intracerebral Liposomal Amphotericin B and Systemic High-Dose Isavuconazole in Proven Disseminated Aspergillosis Open
We report the case of a 32-year-old man receiving chemotherapeutics for an acute B-lymphoblastic leukemia who developed proven cerebral and pulmonary aspergillosis with Aspergillus flavus. Because of progressive fungal disease with neurolo…
View article: DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data
DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data Open
Background DNA mismatch repair deficiency (dMMR) testing is crucial for detection of microsatellite unstable (MSI) tumors. MSI is detected by aberrant indel length distributions of microsatellite markers, either by visual inspection of PCR…
View article: Improved Detection of Disease Progression in Metastatic Breast Cancer by Absolute Molecular Counting of Circulating Tumor DNA: A 100 Copies Question
Improved Detection of Disease Progression in Metastatic Breast Cancer by Absolute Molecular Counting of Circulating Tumor DNA: A 100 Copies Question Open
View article: Additional file 1 of DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data
Additional file 1 of DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data Open
Additional file 1. Implementation pseudocode DeltaMSI.
View article: Supplementary Material for: Cancer registration, molecular marker status and adherence to the WHO 2016 classification of pathology reports for glioma diagnosed during 2017-2019 in Belgium
Supplementary Material for: Cancer registration, molecular marker status and adherence to the WHO 2016 classification of pathology reports for glioma diagnosed during 2017-2019 in Belgium Open
Introduction: The objective of this study is to cross-check and if necessary, adjust registered ICD-O-3 topography and morphology codes with the findings in pathology reports available at the Belgian Cancer Registry (BCR) for glioma patien…
View article: P11.28.A Cancer registration and adherence to the WHO 2016 classification of pathology reports for astrocytic tumors in Belgium from 2017 to 2019
P11.28.A Cancer registration and adherence to the WHO 2016 classification of pathology reports for astrocytic tumors in Belgium from 2017 to 2019 Open
Background The objective of this study is to cross-check the ICD-O-3 topography and morphology codes of registered glioma patients with findings in their pathology reports and to investigate the integration of relevant molecular markers in…
View article: PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment
PRECISION: the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment Open
View article: Abdominal pain in covid times: time to think twice
Abdominal pain in covid times: time to think twice Open
We report a case of abdominal pain followed by acute systolic heart failure due to multisystem inflammatory syndrome in children (MIS-C). This multisystem disease typically appears several weeks after infection with COVID-19 in children an…
View article: DeltaMSI: Artificial Intelligence-based modeling of microsatellite instability scoring by next- generation sequencing
DeltaMSI: Artificial Intelligence-based modeling of microsatellite instability scoring by next- generation sequencing Open
Background : DNA mismatch repair deficiency (dMMR) testing is crucial for detection of microsatellite unstable (MSI) tumors eligible for immunotherapy. MSI is detected by aberrant indel length distributions of microsatellite marker loci, e…
View article: Application of an Ultrasensitive NGS-Based Blood Test for the Diagnosis of Early-Stage Lung Cancer: Sensitivity, a Hurdle Still Difficult to Overcome
Application of an Ultrasensitive NGS-Based Blood Test for the Diagnosis of Early-Stage Lung Cancer: Sensitivity, a Hurdle Still Difficult to Overcome Open
Diagnosis of lung cancer requires histological examination of a tissue sample, which in turn requires an invasive procedure that cannot always be obtained. Circulating tumor DNA can be reliably detected in blood samples of advanced-stage l…
View article: Supplementary Material for: The Use of Pan-Tropomyosin Receptor Kinase Immunohistochemistry as a Screening Tool for the Detection of Neurotrophic Tropomyosin-Related Kinase Fusions: Real-World Data from a National Multicentric Retrospective Study
Supplementary Material for: The Use of Pan-Tropomyosin Receptor Kinase Immunohistochemistry as a Screening Tool for the Detection of Neurotrophic Tropomyosin-Related Kinase Fusions: Real-World Data from a National Multicentric Retrospective Study Open
Introduction: The neurotrophic tropomyosin-related kinase (NTRK) genes encode the tropomyosin receptor kinases (TRKs). Patients with solid tumors harboring an oncogenic NTRK fusion are eligible for treatment wit…
View article: The Use of Pan-Tropomyosin Receptor Kinase Immunohistochemistry as a Screening Tool for the Detection of Neurotrophic Tropomyosin-Related Kinase Fusions: Real-World Data from a National Multicentric Retrospective Study
The Use of Pan-Tropomyosin Receptor Kinase Immunohistochemistry as a Screening Tool for the Detection of Neurotrophic Tropomyosin-Related Kinase Fusions: Real-World Data from a National Multicentric Retrospective Study Open
Introduction: The neurotrophic tropomyosin-related kinase (NTRK) genes encode the tropomyosin receptor kinases (TRKs). Patients with solid tumors harboring an oncogenic NTRK fusion are eligible for treatment wit…
View article: Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma Open
Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly driven by loss of E‐cadherin expression. Correct classification of BC as ILC is important for patient treatment. This study asses…
View article: When hematochezia becomes a red herring
When hematochezia becomes a red herring Open
An 81-year-old male patient presented on the emergency ward for hematochezia, without any other complaints. Rectosigmoidoscopy showed a predominant patchy inflammation of the mucosa with several bluish blebs (submucosal hemorrhage) and sma…
View article: Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study
Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study Open
View article: Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer
Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer Open
View article: Myeloproliferative invasion of arterial walls: Premortem diagnosis by temporal artery biopsy
Myeloproliferative invasion of arterial walls: Premortem diagnosis by temporal artery biopsy Open
A 72-year old woman with a previous history of polycythemia vera presented with acute chest pain. The full blood count showed leukocytosis (WBC 43 × 109/L) with 90.1% neutrophils, microcytic anemia (Hb 103 g/L), thrombocytosis (528 × 109/L…
View article: Comparison of Microsatellite Instability Detection by Immunohistochemistry and Molecular Techniques in Colorectal and Endometrial Cancer
Comparison of Microsatellite Instability Detection by Immunohistochemistry and Molecular Techniques in Colorectal and Endometrial Cancer Open
DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy.In this study, we compared the diagnostic performance of three molecula…
View article: Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential
Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential Open
Shallow-depth sequencing of cell-free DNA, an inexpensive and standardized approach to obtain molecular information on tumors non-invasively, has been insufficiently explored for the diagnosis of lymphoma and disease follow-up. This study …
View article: Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial
Immunohistochemistry as a screening tool for NTRK gene fusions: results of a first Belgian ring trial Open
View article: Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma
Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma Open
View article: Additional file 7 of Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma
Additional file 7 of Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma Open
Additional file 7. Copy number profile data of liquid biopsies (single-end).