Francis E. Sharkey
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View article: NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress Open
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor-permissive genetic mutations, the nature of the cellular origin, and microenvironmental stress. In this study, using primary h…
View article: <i>NF2</i> loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
<i>NF2</i> loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress Open
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor permissive genetic mutations, nature of cellular origin and microenvironmental stress. In this study, using primary human panc…
View article: Integrative multi-omics characterization of hepatocellular carcinoma in Hispanic patients
Integrative multi-omics characterization of hepatocellular carcinoma in Hispanic patients Open
Background The incidence and mortality rates of hepatocellular carcinoma (HCC) among Hispanics in the United States are much higher than those of non-Hispanic whites. We conducted comprehensive multi-omics analyses to understand molecular …
View article: Exploring the role of YAP1 and TAZ in pancreatic acinar cells and the therapeutic potential of VT-104 in pancreatic inflammation
Exploring the role of YAP1 and TAZ in pancreatic acinar cells and the therapeutic potential of VT-104 in pancreatic inflammation Open
Background: Increasing evidence has linked the Hippo pathway with the fibroinflammatory diseases. However, the detailed roles of key hippo components in pancreatic inflammatory diseases still remain unclear. Methods: A series of genetic kn…
View article: Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic Inflammation
Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic Inflammation Open
Increasing evidences have linked the hippo pathway with the fibroinflammatory diseases. We generated a series of genetic knockout mice for targeting the key components of Hippo pathway to examine the individual effects of YAP1 and TAZ on p…
View article: Integrin alpha 6 is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex
Integrin alpha 6 is upregulated and drives hepatocellular carcinoma progression through integrin α6β4 complex Open
Integrin α6 (ITGA6) forms integrin receptors with either integrin β1 (ITGB1) or integrin β4 (ITGB4). How it functions to regulate hepatocellular carcinoma (HCC) progression is not well‐elucidated. We found that ITGA6 RNA and protein expres…
View article: Cholangiolytic Changes in Statin-Induced Liver Injury
Cholangiolytic Changes in Statin-Induced Liver Injury Open
Atorvastatin is a commonly used oral cholesterol-lowering agent. Side effects associated with statin therapy include arthralgia, myalgia, dyspepsia, weakness, and headache. Prospective and retrospective studies of drug-induced liver injury…
View article: Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption
Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption Open
Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via recruitment of immune cells that subsequently activate PSCs. However, whether acinar cells directly contribute to PSC activation is unknown. Here, …
View article: Abstract 96: High iron or high fat diet show similar effects in inducing hepatocellular carcinoma in a mouse model
Abstract 96: High iron or high fat diet show similar effects in inducing hepatocellular carcinoma in a mouse model Open
Introduction: Hepatocellular carcinoma (HCC) has multiple risk factors such as Hepatitis virus infection and obesity. Iron overload may be another risk factor as patients with hemochromatosis have high levels of liver iron accumulation an…
View article: Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation
Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation Open
Objective The Hippo signaling pathway is known for regulating proliferation, differentiation, organ size, and tumorigenesis. Large tumor suppressor kinase 1 and 2 (LATS1&2) are the core kinases of this pathway, whose functions in both the …
View article: Case Report: Fulminant Murine Typhus Presenting with Status Epilepticus and Multi-Organ Failure: an Autopsy Case and a Review of the Neurologic Presentations of Murine Typhus
Case Report: Fulminant Murine Typhus Presenting with Status Epilepticus and Multi-Organ Failure: an Autopsy Case and a Review of the Neurologic Presentations of Murine Typhus Open
Murine typhus (MT) is an important cause of febrile illness in endemic areas, and there is an epidemiologic resurgence of this infection currently transpiring in Texas and California. Fatal cases and severe neurological complications are r…
View article: Sustained-release niacin induced acute liver failure: an autopsy report
Sustained-release niacin induced acute liver failure: an autopsy report Open
Niacin, either alone or in combination with other anti-hyperlipidemic agents, safely and effectively addresses most lipid abnormalities in patients with mixed dyslipidemias. Niacin is the only available agent that significantly lowers lipo…
View article: Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features
Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features Open
Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients …
View article: Spontaneous coronary artery dissection secondary to intimal fibromuscular dysplasia (RCD code: I-1C.O)
Spontaneous coronary artery dissection secondary to intimal fibromuscular dysplasia (RCD code: I-1C.O) Open
Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory arterial disease of unknown etiology. Histologically, FMD is classified on the basis of arterial layer involved into intimal, medial and perimedial types. The medial fo…