Francis Hubler
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View article: Discovery and Characterization of a New Class of C5aR1 Antagonists Showing <i>In Vivo</i> Activity
Discovery and Characterization of a New Class of C5aR1 Antagonists Showing <i>In Vivo</i> Activity Open
C5a is an anaphylatoxin protein produced by the cleavage of the complement system's component C5 protein. It signals through the G-protein-coupled receptor C5a receptor 1 (C5aR1) to induce the chemotaxis of primarily neutrophils and monocy…
View article: Selatogrel, a reversible P2Y12 receptor antagonist, has reduced off-target interference with haemostatic factors in a mouse thrombosis model
Selatogrel, a reversible P2Y12 receptor antagonist, has reduced off-target interference with haemostatic factors in a mouse thrombosis model Open
View article: Selatogrel, the reversible and specific P2Y12 receptor antagonist, does not interfere with haemostasis
Selatogrel, the reversible and specific P2Y12 receptor antagonist, does not interfere with haemostasis Open
Background Combination of a P2Y12 receptor (P2Y12R) antagonist (clopidogrel, prasugrel, ticagrelor) with aspirin is the recommended standard of care for patients with acute coronary syndrome. Selatogrel is a reversible and potent antagonis…
View article: The reversible P2Y<sub>12</sub>antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat
The reversible P2Y<sub>12</sub>antagonist ACT‐246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat Open
The P2Y 12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct‐acting, reversible P2Y 12 antagonists, ACT ‐246475 an…
View article: Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers
Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers Open
View article: CCDC 1043573: Experimental Crystal Structure Determination
CCDC 1043573: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1035297: Experimental Crystal Structure Determination
CCDC 1035297: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1035231: Experimental Crystal Structure Determination
CCDC 1035231: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …