Francis Lacombe
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View article: Krypton: Nonlinear Parabolized Stability Equation solver for transonic flow in curvilinear coordinates
Krypton: Nonlinear Parabolized Stability Equation solver for transonic flow in curvilinear coordinates Open
View article: Unsupervised cluster analysis and subset characterization of abnormal erythropoiesis using the bioinformatic <scp>Flow‐Self</scp> Organizing Maps algorithm
Unsupervised cluster analysis and subset characterization of abnormal erythropoiesis using the bioinformatic <span>Flow‐Self</span> Organizing Maps algorithm Open
Background The Flow‐Self Organizing Maps (FlowSOM) artificial intelligence (AI) program, available within the Bioconductor open‐source R‐project, allows for an unsupervised visualization and interpretation of multiparameter flow cytometry …
View article: 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party
2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party Open
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML) that is used for prognostic, predictive, monitoring, and efficacy-response assessments. The European LeukemiaNet (ELN) MRD Working Party evaluated …
View article: Unsupervised flow cytometry analysis in hematological malignancies: A new paradigm
Unsupervised flow cytometry analysis in hematological malignancies: A new paradigm Open
Ever since hematopoietic cells became “events” enumerated and characterized in suspension by cell counters or flow cytometers, researchers and engineers have strived to refine the acquisition and display of the electronic signals generated…
View article: Unsupervised Flow Cytometry Analysis Allows for an Accurate Identification of Minimal Residual Disease Assessment in Acute Myeloid Leukemia
Unsupervised Flow Cytometry Analysis Allows for an Accurate Identification of Minimal Residual Disease Assessment in Acute Myeloid Leukemia Open
The assessment of minimal residual disease (MRD) is increasingly considered to monitor response to therapy in hematological malignancies. In acute myeloblastic leukemia (AML), molecular MRD (mMRD) is possible for about half the patients wh…
View article: Definition of Erythroid Differentiation Subsets in Normal Human Bone Marrow Using FlowSOM Unsupervised Cluster Analysis of Flow Cytometry Data
Definition of Erythroid Differentiation Subsets in Normal Human Bone Marrow Using FlowSOM Unsupervised Cluster Analysis of Flow Cytometry Data Open
Erythropoiesis is a complex process that ensures the production of about 200 billion erythrocytes every day, at a rate of almost 2 million per second in humans. Knowledge of the maturation process of red blood cells comes mostly from morph…
View article: An R‐Derived FlowSOM Process to Analyze Unsupervised Clustering of Normal and Malignant Human Bone Marrow Classical Flow Cytometry Data
An R‐Derived FlowSOM Process to Analyze Unsupervised Clustering of Normal and Malignant Human Bone Marrow Classical Flow Cytometry Data Open
Multiparameter flow cytometry (MFC) is a powerful and versatile tool to accurately analyze cell subsets, notably to explore normal and pathological hematopoiesis. Yet, mostly supervised subjective strategies are used to identify cell subse…
View article: Innovation in Flow Cytometry Analysis: A New Paradigm Delineating Normal or Diseased Bone Marrow Subsets Through Machine Learning
Innovation in Flow Cytometry Analysis: A New Paradigm Delineating Normal or Diseased Bone Marrow Subsets Through Machine Learning Open
Supplemental Digital Content is available in the text
View article: Innovation in Flow Cytometry Analysis
Innovation in Flow Cytometry Analysis Open
View article: Gravitational stress during parabolic flights reduces the number of circulating innate and adaptive leukocyte subsets in human blood
Gravitational stress during parabolic flights reduces the number of circulating innate and adaptive leukocyte subsets in human blood Open
Gravitational stress occurs during space flights or certain physical activities including extreme sports, where the change in experienced gravitational acceleration can reach large magnitudes. These changes include reduction and increase i…
View article: Reference Values for WBC Differential by Hematoflow Analysis
Reference Values for WBC Differential by Hematoflow Analysis Open
These normal values will be helpful in the definition of relevant threshold for the automatic validation of samples analyzed by flow cytometry and the flagging of pathologic samples.
View article: Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party
Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party Open
Measurable residual disease (MRD; previously termed minimal residual disease) is an independent, postdiagnosis, prognostic indicator in acute myeloid leukemia (AML) that is important for risk stratification and treatment planning, in conju…
View article: Harmonemia: a universal strategy for flow cytometry immunophenotyping—A European LeukemiaNet WP10 study
Harmonemia: a universal strategy for flow cytometry immunophenotyping—A European LeukemiaNet WP10 study Open
View article: The routine leukocyte differential flow cytometry<scp>H</scp>emato<scp>F</scp>low™ method: A new flagging system for automatic validation
The routine leukocyte differential flow cytometry<span>H</span>emato<span>F</span>low™ method: A new flagging system for automatic validation Open
The complete blood cell count and white blood cell differential are the first step in the biological diagnosis of hematological diseases. Both are currently performed by automated instruments which control data and produce alerts. If such …