Francis Migneault
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View article: Endothelial extracellular vesicle miR-423-5p regulates microvascular homeostasis and renal function after ischemia-reperfusion injury
Endothelial extracellular vesicle miR-423-5p regulates microvascular homeostasis and renal function after ischemia-reperfusion injury Open
Microvascular rarefaction substantially contributes to renal dysfunction following ischemia-reperfusion injury (IRI). We characterized the microRNA signature of extracellular vesicles (EVs) released during endothelial apoptosis to identify…
View article: Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of<i>GCK</i>-MODY
Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of<i>GCK</i>-MODY Open
Glucokinase (GK) catalyses the key regulatory step in glucose-stimulated insulin secretion. Correspondingly, hetero– and homozygous mutations in human GCK cause maturity-onset diabetes of the young (GCK-MODY) and permanent neonatal diabete…
View article: Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes Open
Apoptotic exosome-like vesicles (ApoExos) are a novel type of extracellular vesicle that contribute to the propagation of inflammation at sites of vascular injury when released by dying cells. ApoExos are characterized by the presence of t…
View article: 501 Anti-LG3 antibodies contribute to microvascular loss and fibrosis in lupus nephritis
501 Anti-LG3 antibodies contribute to microvascular loss and fibrosis in lupus nephritis Open
Background Lupus nephritis (LN) is a common and serious manifestation of systemic lupus erythematosus (SLE) and 30% of cases, affected patients progress to end stage renal disease (ESRD). Microvascular damage is an emerging contributing fa…
View article: Autophagy drives fibroblast senescence through MTORC2 regulation
Autophagy drives fibroblast senescence through MTORC2 regulation Open
Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibr…
View article: Autophagy drives fibroblast senescence through MTORC2 regulation
Autophagy drives fibroblast senescence through MTORC2 regulation Open
Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibr…
View article: Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs Open
Endothelial cells have multifaceted interactions with the immune system, both as initiators and targets of immune responses. In vivo , apoptotic endothelial cells release two types of extracellular vesicles upon caspase-3 activation: apopt…
View article: Post-Transcriptional Modulation of αENaC mRNA in Alveolar Epithelial Cells: Involvement of its 3’ Untranslated Region
Post-Transcriptional Modulation of αENaC mRNA in Alveolar Epithelial Cells: Involvement of its 3’ Untranslated Region Open
Taken together, these findings indicate that the αENaC 3'UTR plays an important role in modulating transcript levels, and Dhx36 and Tial1 seem to be involved in posttranscriptional regulation of αENaC expression in alveolar epithelial cell…