Francisca Acuña
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View article: Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors
Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors Open
Inhibition plays a key role in brain functions. While typically linked to GABA, inhibition can be induced by glutamate via metabotropic glutamate receptors (mGluRs). Here, we investigated the role of mGluR-mediated inhibition in the habenu…
View article: Genome sequencing reveals <i>CCDC88A</i> variants in malformations of cortical development and immune dysfunction
Genome sequencing reveals <i>CCDC88A</i> variants in malformations of cortical development and immune dysfunction Open
Malformations of cortical development (MCDs) encompass a diverse group of genetic and clinical disorders. Here, we aimed to determine a genetic etiology for two siblings manifesting MCD, microcephaly, epilepsy, intellectual disability, and…
View article: Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors
Inhibition mediated by group III mGluRs regulates habenula activity and defensive behaviors Open
Inhibition contributes to various brain computations from sensory motor transformations to cognitive operations. While most studies on inhibition focus on GABA, the main excitatory neurotransmitter of the brain, glutamate, can also elicit …
View article: Efferent Control in Musicians: A Review
Efferent Control in Musicians: A Review Open
It is widely established that musicians possess a higher level in certain auditory perceptual abilities when compared to non-musicians. This improvement may be mediated, at least in part, by changes in the cochlear response induced by refl…
View article: Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain
Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain Open
Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. …
View article: Free-roaming domestic cats near conservation areas in Chile: Spatial movements, human care and risks for wildlife
Free-roaming domestic cats near conservation areas in Chile: Spatial movements, human care and risks for wildlife Open
Free-roaming domestic cats can negatively affect wildlife, and understanding how they use space is fundamental to predict their potential impacts. In this study we describe the use of space of 48 owned free-roaming cats and assess the leve…
View article: Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines
Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines Open
Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. Under stressful c…
View article: Cross‐species transmission of retroviruses among domestic and wild felids in human‐occupied landscapes in Chile
Cross‐species transmission of retroviruses among domestic and wild felids in human‐occupied landscapes in Chile Open
Human transformation of natural habitats facilitates pathogen transmission between domestic and wild species. The guigna ( Leopardus guigna ), a small felid found in Chile, has experienced habitat loss and an increased probability of conta…
View article: Epidemiology and molecular characterization of <i>Carnivore protoparvovirus‐1</i> infection in the wild felid <i>Leopardus guigna</i> in Chile
Epidemiology and molecular characterization of <i>Carnivore protoparvovirus‐1</i> infection in the wild felid <i>Leopardus guigna</i> in Chile Open
Landscape anthropization has been identified as one of the main drivers of pathogen emergence worldwide, facilitating pathogen spillover between domestic species and wildlife. The present study investigated Carnivore protoparvovirus-1 infe…
View article: Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis Open
Sequential neurogenesis determines the functional properties of habenular neurons.
View article: Herpes Simplex Virus type 1 neuronal infection triggers disassembly of key structural components of dendritic spines
Herpes Simplex Virus type 1 neuronal infection triggers disassembly of key structural components of dendritic spines Open
Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. The primary infection in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. Under stressful condit…
View article: Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit
Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit Open
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus able to reach the central nervous system (CNS) after primary infection in oronasal mucosa. HSV-1 establishes latency inside neurons due the repression of its gene expression proces…
View article: Molecular and serological survey of carnivore pathogens in free-roaming domestic cats of rural communities in southern Chile
Molecular and serological survey of carnivore pathogens in free-roaming domestic cats of rural communities in southern Chile Open
Owned, free-roaming domestic cats are abundant in the Chilean countryside, having high probability of contact with wildlife and potentially participating as reservoirs of zoonotic pathogens. In the present study, 131 cats from two remote s…
View article: <b>Contrasting human perceptions of and attitudes towards two threatened small carnivores, <I>Lycalopex fulvipes</I> and <I>Leopardus guigna</I>, in rural communities adjacent to protected areas in Chile</b>
<b>Contrasting human perceptions of and attitudes towards two threatened small carnivores, <i>Lycalopex fulvipes</i> and <i>Leopardus guigna</i>, in rural communities adjacent to protected areas in Chile</b> Open
The interaction between humans and small carnivores is a phenomenon especially frequent in rural fringes, as is the case of communities surrounding natural areas. In Chile, two species of threatened carnivores, the Darwin’s Fox and the Gui…
View article: Herpes Simplex Virus Type 1 at the Central Nervous System
Herpes Simplex Virus Type 1 at the Central Nervous System Open
Herpes simplex virus type 1 (HSV‐1) is a ubiquitous and neurotropic pathogen and is the most common cause of acute sporadic encephalitis in humans. This virus is characterized by establishing a persistent latent infection in neurons of its…