Francisco Portela
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View article: A influência do eixo microbiota–intestino–cérebro na saúde mental e na saúde intestinal
A influência do eixo microbiota–intestino–cérebro na saúde mental e na saúde intestinal Open
Contexto: O eixo microbiota–intestino–cérebro (EMIC) representa uma complexa rede de comunicação que integra sistemas neurais, imunológicos, endócrinos e metabólicos, conectando de forma essencial a saúde intestinal à saúde mental. A liter…
View article: THE INFLUENCE OF THE MICROBIOTA–GUT–BRAIN AXIS ON MENTAL HEALTH AND INTESTINAL HEALTH
THE INFLUENCE OF THE MICROBIOTA–GUT–BRAIN AXIS ON MENTAL HEALTH AND INTESTINAL HEALTH Open
Background: The microbiota–gut–brain axis (MGBA) represents a complex communication network integrating neural, immune, endocrine, and metabolic systems, critically linking intestinal health to mental health. Scientific literature has cons…
View article: A INFLUÊNCIA DO EIXO MICROBIOTA–INTESTINO– CÉREBRO NA SAÚDE MENTAL E NA SAÚDE INTESTINAL
A INFLUÊNCIA DO EIXO MICROBIOTA–INTESTINO– CÉREBRO NA SAÚDE MENTAL E NA SAÚDE INTESTINAL Open
Contexto: O eixo microbiota–intestino–cérebro (EMIC) representa uma complexa rede de comunicação que integra sistemas neurais, imunológicos, endócrinos e metabólicos, conectando de forma essencial a saúde intestinal à saúde mental. A liter…
View article: Antidepressants in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials
Antidepressants in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials Open
Antidepressants demonstrate efficacy in IBS. These medications can be beneficial to patients resistant to initial treatments and those lacking psychopathological symptoms.
View article: Authors’ reply
Authors’ reply Open
View article: Nested Randomized Controlled Trials in Large Databases: An Opportunity for Inflammatory Bowel Disease?
Nested Randomized Controlled Trials in Large Databases: An Opportunity for Inflammatory Bowel Disease? Open
Introduction Although randomized controlled trials (RCTs) are the gold standard for investigating the efficacy and safety of interventions, they present major operational challenges due to their complexity, time-consuming nature, and costs…
View article: eLIFEwithIBD: study protocol for a randomized controlled trial of an online acceptance and commitment therapy and compassion-based intervention in inflammatory bowel disease
eLIFEwithIBD: study protocol for a randomized controlled trial of an online acceptance and commitment therapy and compassion-based intervention in inflammatory bowel disease Open
Background Inflammatory bowel disease (IBD) entails physical, psychological, and social burden and holds a significant impact on quality of life. Experiential avoidance, cognitive fusion, shame, and self-criticism have been identified as p…
View article: Cirugía en pacientes con valvulopatía aórtica bicúspide versus tricúspide: características quirúrgicas y resultados a medio plazo
Cirugía en pacientes con valvulopatía aórtica bicúspide versus tricúspide: características quirúrgicas y resultados a medio plazo Open
Introducción y objetivo:
\nDeterminar diferencias clínicas y quirúrgicas entre pacientes con válvula aórtica tricúspide (VAT) y válvulas aórticas bicúspides (VAB).
\nMétodos:
\nSe revisaron retrospectivamente 429 pacientes adultos que se s…
View article: Randomized controlled trial of an Acceptance and Commitment Therapy and compassion-based group intervention for persons with inflammatory bowel disease: the LIFEwithIBD intervention
Randomized controlled trial of an Acceptance and Commitment Therapy and compassion-based group intervention for persons with inflammatory bowel disease: the LIFEwithIBD intervention Open
Objectives This study tested the acceptability and efficacy of an Acceptance and Commitment Therapy and compassion-based intervention (LIFEwithIBD) in people with IBD through a two-arm RCT. Methods Participants were recruited at the Gastro…
View article: From Intravenous to Subcutaneous Infliximab: the Same but Different? Real-World Evidence from a Tertiary Center
From Intravenous to Subcutaneous Infliximab: the Same but Different? Real-World Evidence from a Tertiary Center Open
Introduction. Recently, a subcutaneous formulation of infliximab was approved. The switch from intravenous infliximab to subcutaneous infliximab may improve convenience, but data on pharmacokinetics and immunogenicity are limited. We aimed…
View article: P430 The influence of persistent organ damage on IFX pharmacokinetic modeling and disease progression assessment: findings from a prospective real-world study in inflammatory bowel disease patients
P430 The influence of persistent organ damage on IFX pharmacokinetic modeling and disease progression assessment: findings from a prospective real-world study in inflammatory bowel disease patients Open
Background Effective management of inflammatory bowel disease (IBD) relies on a comprehensive understanding of infliximab (IFX) pharmacokinetics (PK). This study's primary goal was to develop a robust PK model, identifying key covariates i…
View article: Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 months of maintenance treatment with infliximab
Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 months of maintenance treatment with infliximab Open
In CD patients in maintenance treatment with infliximab, combination treatment does not seem to have benefits over infliximab monotherapy beyond 12 months of treatment duration.
View article: Postoperative Recurrence of Crohn’s Disease–Is the Early Use of Postoperative Immunomodulators Able to Modify Prognosis?
Postoperative Recurrence of Crohn’s Disease–Is the Early Use of Postoperative Immunomodulators Able to Modify Prognosis? Open
Introduction: Many patients with Crohn’s Disease (CD) require surgical resection during their lifetime. Nevertheless, postoperative recurrence (POR) is common. Risk factors for POR are still yet to be completely established, but some progn…
View article: How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?—A prospective study
How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?—A prospective study Open
Background Timely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. Ob…
View article: P170 Can histological activity of ulcerative colitis be predicted by assessment of the rectosigmoid colon?
P170 Can histological activity of ulcerative colitis be predicted by assessment of the rectosigmoid colon? Open
Background Rectosigmoidoscopy is frequently used to assess disease activity in patients with ulcerative colitis (UC). Most recent guidelines suggest that the inflammatory activity of the whole colon can be inferred by endoscopic findings i…
View article: Diagnosis of Bowel Endometriosis Using Endoscopic Ultrasound-guided Fine Needle Aspiration
Diagnosis of Bowel Endometriosis Using Endoscopic Ultrasound-guided Fine Needle Aspiration Open
Endometriosis is a relatively common gynecological condition in women of reproductive age. The rectosigmoid region is the most commonly affected segment when the gastrointestinal tract is involved. A differential diagnosis of colorectal ne…
View article: Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease Open
Introduction Evidence supporting transmural remission ( TR ) as a long‐term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic ( IER ) or radiologic remissio…
View article: Starting gastrointestinal endoscopy in a lower middle-income country in Africa: Training, creating an endoscopy facility and developing telemedicine
Starting gastrointestinal endoscopy in a lower middle-income country in Africa: Training, creating an endoscopy facility and developing telemedicine Open
Background and study aims The prevalence of digestive diseases seems to be high in African countries. Nonetheless, the human and material resources are scarce. The aim of the Portuguese volunteering project described in this report was to …
View article: Corrigendum: The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease
Corrigendum: The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease Open
[This corrects the article DOI: 10.3389/fpsyt.2021.699367.].
View article: Breaking barriers in cardiac donation after circulatory death.
Breaking barriers in cardiac donation after circulatory death. Open
Background: Heart transplant from controlled donation after circulatory death (cDCD) is an emerging strategy that is rapidly expanding and may help increase the heart donor pool. Materials and Methods: The use of thoracoabdominal normother…
View article: Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal
Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal Open
Background: Inflammatory bowel diseases’ (IBD) increasing incidence and prevalence place a heavy health and economic burden on society. Objectives: This study assesses the burden and cost of IBD in Portugal to support the definition of hea…
View article: Reparación tricuspídea asociada a la prótesis pulmonar en la reintervención de Fallot: ¿cuándo y cómo?
Reparación tricuspídea asociada a la prótesis pulmonar en la reintervención de Fallot: ¿cuándo y cómo? Open
Resumen: Según las series, aproximadamente un 30% de los pacientes corregidos de Fallot mediante parche transanular pueden tener comprometida la funcionalidad de la válvula tricúspide en el momento del reemplazo valvular pulmonar (RVP). Es…
View article: Su1501: PROPHYLACTIC VERSUS ENDOSCOPY DRIVEN TREATMENT OF CROHN'S POSTOPERATIVE RECURRENCE: A RETROSPECTIVE MULTICENTRIC EUROPEAN STUDY
Su1501: PROPHYLACTIC VERSUS ENDOSCOPY DRIVEN TREATMENT OF CROHN'S POSTOPERATIVE RECURRENCE: A RETROSPECTIVE MULTICENTRIC EUROPEAN STUDY Open
View article: Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World?
Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World? Open
INTRODUCTION: Inflammatory bowel disease (IBD) affects people from all age categories worldwide. Although the incidence of the disease is stabilizing or decreasing in most Western world countries, its prevalence is still increasing because…
View article: Enfermedad del tronco coronario izquierdo en las guías clínicas del ACC/AHA/SCAI del 2021: un tema muy controvertido
Enfermedad del tronco coronario izquierdo en las guías clínicas del ACC/AHA/SCAI del 2021: un tema muy controvertido Open
View article: Corrigendum: The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease
Corrigendum: The LIFEwithIBD Intervention: Study Protocol for a Randomized Controlled Trial of a Face-to-Face Acceptance and Commitment Therapy and Compassion-Based Intervention Tailored to People With Inflammatory Bowel Disease Open
[This corrects the article DOI: 10.3389/fpsyt.2021.699367.].
View article: Why Does the NOTION Trial Show Poorer than Expected Outcomes in the Surgical Arm?
Why Does the NOTION Trial Show Poorer than Expected Outcomes in the Surgical Arm? Open
The NOTION trial compares transcatheter aortic valve implantation versus surgical aortic valve replacement in low-risk patients. Looking carefully at the outcomes of this trial, there is no doubt that the transcatheter aortic valve implant…
View article: Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis
Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis Open
Background: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to evaluate whether the number and type of variables included affect the frequency of the …
View article: P221 Association between Irritable Bowel Syndrome-type symptoms and Ulcerative Colitis: is it real?
P221 Association between Irritable Bowel Syndrome-type symptoms and Ulcerative Colitis: is it real? Open
Background The origin of gastrointestinal symptoms compatible with irritable bowel syndrome (IBS) in patients with inflammatory bowel disease in remission is a challenge. Our aim was to prospectively determine the relation of IBS symptoms …
View article: Supplementary Material for: Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal
Supplementary Material for: Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal Open
Background: Inflammatory bowel diseases’ (IBD) increasing incidence and prevalence place a heavy health and economic burden on society. Objectives: This study assesses the burden and cost of IBD in Portugal to s…